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Trump 2.0 has a Cabinet and executive branch of different ideas and eclectic personalitiesSAN DIEGO and TORONTO, Nov. 25, 2024 (GLOBE NEWSWIRE) — Aptose Biosciences Inc. (“Aptose” or the “Company”) (NASDAQ: APTO, TSX: APS), a clinical-stage precision oncology company developing highly differentiated oral targeted agents to treat hematologic malignancies, today announced the closing of its previously announced “reasonable best efforts” public offering with participation from the CEO and existing and new healthcare focused investors for the purchase and sale of 40,000,000 common shares at a price of $0.20 per share and warrants to purchase up to 20,000,000 common shares (the “Offering”). The warrants have an exercise price of $0.25 per share, are exercisable immediately and will expire five years from the issuance date. The Company received aggregate gross proceeds of $8 million, before deducting placement agent fees and other offering expenses, and intends to use the net proceeds from this Offering for working capital and general corporate purposes. A.G.P./Alliance Global Partners is acting as the sole placement agent for the Offering. The securities described above were offered pursuant to a registration statement on Form S-1 (File No. 333-281201) previously filed with the Securities and Exchange Commission (“SEC”) on August 2, 2024, as amended, which was declared effective on November 21, 2024. This Offering was made only by means of a prospectus forming part of the effective registration statement. A preliminary prospectus relating to the Offering has been filed with the SEC. An electronic copy of the final prospectus relating to the Offering may be obtained on the SEC’s website located at http://www.sec.gov and may also be obtained from A.G.P./Alliance Global Partners, 590 Madison Avenue, 28th Floor, New York, NY 10022, or by telephone at (212) 624-2060, or by email at . This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. Aptose Biosciences is a clinical-stage biotechnology company committed to developing precision medicines addressing unmet medical needs in oncology, with an initial focus on hematology. The Company’s small molecule cancer therapeutics pipeline includes products designed to provide single agent efficacy and to enhance the efficacy of other anti-cancer therapies and regimens without overlapping toxicities. The Company’s lead clinical-stage, oral kinase inhibitor tuspetinib (TUS) has demonstrated activity as a monotherapy and in combination therapy in patients with relapsed or refractory acute myeloid leukemia (AML), and is being developed as a frontline triplet therapy in newly diagnosed AML. For more information, please visit . This press release contains forward-looking statements within the meaning of Canadian and U.S. securities laws, including, but not limited to, statements relating to the intended use of proceeds and statements relating to the Company’s plans, objectives, expectations and intentions and other statements including words such as “continue”, “expect”, “intend”, “will”, “hope” “should”, “would”, “may”, “potential” and other similar expressions. Such statements reflect our current views with respect to future events and are subject to risks and uncertainties and are necessarily based upon a number of estimates and assumptions that, while considered reasonable by us, are inherently subject to significant market and other conditions, business, economic, competitive, political and social uncertainties and contingencies. Many factors could cause our actual results, performance or achievements to be materially different from any future results, performance or achievements described in this press release. Such factors could include, among others: our ability to obtain the capital required for research and operations; the inherent risks in early stage drug development including demonstrating efficacy; development time/cost and the regulatory approval process; the progress of our clinical trials; our ability to find and enter into agreements with potential partners; our ability to attract and retain key personnel; changing market and economic conditions; unexpected manufacturing defects and other risks detailed from time-to-time in our ongoing current reports, quarterly filings, annual information forms, annual reports and annual filings with Canadian securities regulators and the United States Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should the assumptions set out in the section entitled “Risk Factors” in our filings with Canadian securities regulators and the United States Securities and Exchange Commission underlying those forward-looking statements prove incorrect, actual results may vary materially from those described herein. These forward-looking statements are made as of the date of this press release and we do not intend, and do not assume any obligation, to update these forward-looking statements, except as required by law. We cannot assure you that such statements will prove to be accurate as actual results and future events could differ materially from those anticipated in such statements. Investors are cautioned that forward-looking statements are not guarantees of future performance and accordingly investors are cautioned not to put undue reliance on forward-looking statements due to the inherent uncertainty therein. For further information, please contact:
David E. “Dave” Nething of Jamestown, ND died December 2, 2024, of natural causes at SMP Health - Ave Maria, Jamestown, ND at the age of 91. Twice each day for many years, Dave prayed to God he would be a better person and a better friend in Jesus than he was the day before. He knew when he reached the ultimate being the best person he could and the best friend of Jesus possible for him; God would take him from his earthly life. It is his life we will celebrate at United Presbyterian Church in Jamestown, ND on December 11, 2024 at 10:30 a.m. Arrangements are in the care of Eddy Funeral Home. Dave was born June 29, 1933 in Valley City, ND when his family lived in Wimbledon. The family moved to Pingree where he attended school leaving the last semester of high school to enter the military service. His diploma was granted in May of 1951. When he entered active federal duty he went to Camp Rucker, Alabama in 1951. He entered Jamestown College in 1952 and graduated in 1956. It was in college where he met and married Marjorie Moffatt of Rugby, ND in 1955. In the autobiography and memoirs book he wrote for his grandchildren and great-grandchildren in 2011, he dedicated it to Marge and said the following: “Throughout our life together, she has been my best friend and supporter. Starting with our first meeting, you need to realize whatever I accomplished, her presence and willingness to endure were ever present. Without her steady guidance, our lives would never have matured to the level we have enjoyed.” His college part-time jobs included part owner of a service station in Pingree with his brother Edwin, college bookstore, Jimmy Grill, construction truck driver, railroad section crew, radio announcer, school bus driver, college commons (kitchen help) and railroad yard clerk. His first job out of college was high school principal and teacher at Pingree High School. In addition, he coached boys & girls basketball and softball. The following year he started working in insurance and real estate business in Jamestown. He entered the University of North Dakota Law School and graduated in 1963 with a Juris Doctorate (JD) degree with Honors. During the summers of Law School he worked in Alaska for the State Department, and part time waiter in the Red Dog Saloon and radio announcer. He passed the North Dakota Bar Exam in 1963, then went to work in the office of the Attorney General in Bismarck. In 1964, he opened his law office in Jamestown. He was appointed Assistant State’s Attorney for Stutsman County through 1969 and did all prosecution of criminal cases. In 1965, he formed a partnership with Clint Ottmar which was continued to 1976. During this time he was a part-time Business Law instructor at Jamestown College and the Assistant City Attorney for Jamestown, ND. From 1976 thru 2000 he was a sole practitioner of law and was the City Attorney for Jamestown, for four years. He was very active in his community including serving on the Jamestown Stutsman County Business & Industrial Development Commission, Commissioner Chairman of ND Supreme Court Grievance Commission, Presbyterian Church Trustee and Deacon, President of Rotary, Director of Stutsman County Fair Board, Director of Camp Rokiwan Board, Delegate to ND Constitution Convention, member of American Legion and Masonic Bodies. He enjoyed politics and became very active in the Republican Party. He served as Secretary for the Stutsman County Republican Committee, State Chairman, ND Young Republicans and on various District and State Committees. In 1960, he was a Delegate to the National Republican Convention held in Chicago. In 1966, he was elected to the North Dakota Senate and served until his retirement in 2012. At that time he was the longest serving Republican State Senator in the United States. He thoroughly enjoyed serving in the legislature and served on 26 different committees during his 46 years. He was elected Senate Majority leader in 1974 thru 1986 and was elected President Pro-tem 1997-98. In 1985-86, he was elected President of the National Conference of State Legislatures, the only legislator from ND to hold that office Higher Education Policy was of special interest. He served on the Western Interstate Commission of Higher Education (WICHE) and was Chairman in 2005. He was also very interested in telecommunications. He was the prime sponsor of legislation to provide Telecommunication Regulatory reform in North Dakota. He was very active in the Benevolent and Protective Order of Elks. Locally he was Exalted Ruler and served on many committees. He was a trustee for the North Dakota Elks Association and served as Chairman of the Board. He received 28 different recognition awards during his time in legislature. In addition, he was inducted into Jamestown College Hall of Fame. Received the “Greater North Dakotan” Award from Greater North Dakota Association. Was presented the “Commodore in the ND Mythical Navy” Award for unwavering support of water issues from Governor Hoven and the North Dakota Water Users Association. In 2012 was the recipient of an Honorary Doctor of Letters degree from the University of North Dakota. Dave was an energetic, loving, caring and positive thinking man whose life centered on his state, community, family and his faith in God. He instilled these values in his children and taught them the importance of faith, love and family. His wife, children, grandchildren and great grandchildren all brought joy to him in many different ways and he was very proud of each of them and their spouses. In 2011 Dave became an author and over several years presented his family with 4 books “Grandpa Dave, Citizen Senator”, “Grandpa Dave: the Person and the Family” “Grandpa Dave and Grandma Marge - Lonesome Lovers - Alaska - Summer of 1961” and in 2024, ”Grandpa Dave: A Lifetime of Activities.” Dave enjoyed writing about family history especially for his grandchildren. He is survived by his best friend and supporter for 69 years, Marjorie, three children, Deborrah (Francis) Lee, Scot (Darlene) Nething, and Melissa, (Rick) Morris all of Jamestown, Granddchildren: Jeff (Jill) Lee and daughters: Arya & Kyra; Heidi (Nick) Bollinger and sons: Cashton & Jack; Andy Lee (Kalli Swenson); Robyn Nething; Ben (DeeAnn) Lee and children: Danica, Silas, Lila, June, Ruby and sister-in-law Bonnie and (Tom) Lavik of Blaine, MN. He was preceded in death by parents, Edwin Sr. and Esther Stein Nething, siblings Edwin (Lorrie) Nething, Dorothy (Jack) Swearingen, Marlen (Art) Gray, Marge’s parents James and Emma Moffatt, and his paternal grandparents August and Lizzie Nething and maternal grandparents E.W. and Hulda Stein. In lieu of flowers, memorial may be sent to SMP Health - Ave Maria, 501 19th St. NE, Jamestown; Jamestown Regional Medical Center, 2422 20th St. SW, Jamestown; or the charity of choice.
Stick to tax vow CHANCELLOR Rachel Reeves insists she will never repeat her inflationary, business-bashing Budget, and that she had “no alternative.” Voters will question if this is really true. After all, as the Tories imploded, she had months to prepare a radical programme. Labour could have unveiled credible plans to slash Government spending. Instead it opted for bumper public sector pay-rises, including 15 per cent for train drivers. She could have laid waste to the aid budget. READ MORE FROM THE SUN SAYS Instead farmers overseas are handed £500m of our money — while Reeves whacks British farms for the same amount in Inheritance Tax . Or perhaps the Chancellor could have foreseen that businesses would not be able to simply absorb the impact of her £25billion National Insurance rise , which will now inevitably lead to job losses and higher prices. Reeves — who deserves credit for at least sparing motorists a fuel duty rise , in the most popular measure in her Budget — feels able to predict she won’t have to launch another tax bombshell. For her sake and everybody else’s, the Chancellor had better be right. Most read in The Sun Skint workers and employers bucking under the weight of record taxes can’t take much more. Woke-us pocus HOLLYWOOD’s backing for JK Rowling over the new Harry Potter franchise is another welcome sign that the woke culture suffocating our lives is being dismantled. Rowling has been a staunch defender of women’s safety and rights. For this she has been relentlessly trolled and pilloried online. In the face of such vile bullying she has remained resolute. Not so the actors who made their fame and fortune off the back of Rowling’s brilliant imagination. Emma Watson , Daniel Radcliffe and Rupert Grint cravenly betrayed her to the trans extremists. In standing by the decision to keep Rowling as a producer on a new Potter series, TV execs at HBO have signalled a major sea change. That the spiteful hate mob that infests social media won’t win over plain common sense. Chagos shame THE sight of our new National Security Adviser scurrying to Mauritius to give away the Chagos islands shames Britain. READ MORE SUN STORIES Jonathan Powell is desperate to sew up the grubby deal before Donald Trump — who hates the idea — becomes president. Such blatant poking of our strongest ally over global defence is a folly which makes our key interests less secure.Will Quebec be ready for the EV shift by 2035?
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