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Real Madrid, under the guidance of their experienced manager Zinedine Zidane, have also been in impressive form, combining defensive solidity with lethal counter-attacking prowess. The team's depth and quality in every department have seen them grind out crucial wins and remain hot on the heels of their rivals.Company investing $193M in Chatham CountyThe much-anticipated match between Real Madrid and Atalanta is finally here, as the two teams meet again after a 4-month hiatus. With Real Madrid emerging victorious in all three previous encounters, fans are eager to see if Atalanta can turn the tide this time around.
The process of redeeming your rewards on Game Merchant Coins is straightforward. Simply accumulate the required number of coins by completing tasks and challenges within the platform. Once you have earned enough coins, you can browse through the extensive catalog of rewards and choose the ones that best suit your preferences. From digital goodies to physical merchandise, the options are endless.Top 10 movies of 2024: In a time of scoundrels, ‘Brutalist,’ ‘Challengers’ and the movie about the exotic dancerFor Rafael, retiring from professional football is not just the end of a playing career, but the beginning of a new chapter in his life. As he looks towards the future, Rafael is grateful for the experiences, friendships, and memories that football has given him. He leaves the game with his head held high, knowing that he gave his all every time he stepped onto the pitch.
Pfizer hosted a discussion with sell-side analysts to provide an update on one of the vaccine pipeline items – a second-generation Clostridioides difficile (C. diff) vaccine effort in Phase 2. Goldman Sachs analyst Chris Shibutani maintained a Buy rating on Pfizer, Inc PFE with a price target of $33 . Shibutani recalled that Pfizer had reported negative results from a Phase 3 study for a first-generation asset in March 2022, where the primary endpoint was unmet. Also Read: Elon Musk’s xAI To Expand With New Chatbot App Still, results did include signals from secondary endpoints that suggested reduced disease severity. Pfizer has since been exploring updated formulations (reducing the 3-dose regimen to 2 doses), including a version in Phase 2. Immunogenicity data are anticipated in 2025, with potential for advancement into Phase 3 by the end of 2025. For a potential Phase 3 study, Shibutani noted the objective would be to discern the potential to reduce the severity of a C. diff infection (CDI) instead of aiming to reduce the risk and prevention of disease. Pfizer estimates ~500k infections annually in the U.S., and no vaccine options currently available. Acknowledging that there is an unmet need The analyst acknowledged that there is an unmet need and said the data thus far suggests a potential basis for a path forward for the program in the context of comments from R&D leadership during the discussion Shibutani hosted with investors. The emphasis on the forward will be on programs with the most significant potential for economic returns. The analyst expects that investor enthusiasm will likely remain relatively subdued, especially in the context of uncertainties deriving from health policy dynamics relating to vaccines, that are an overhang to sentiment. Shibutani does not currently include revenue estimates for a C. diff vaccine in his model and looks to monitor data updates and decisions regarding plans for this program to guide his forecasts in the future. Separately, the analyst flagged Pfizer management’s mention of the fourth generation 25-valent pneumococcal vaccine (PCV), which management affirms continues to progress in Phase 2. Shibutani recalled that Pfizer had previously commented that the immunogenicity data from Phase 1 were encouraging, as highlighted by the improved immunogenicity observed for serotype 3. Pfizer is currently in a Phase 2 proof-of-concept study for its second-generation Clostridioides difficile (C. diff) vaccine, PF-07831694. This vaccine targets C. diff toxins A and B, which cause Clostridioides difficile infection (CDI). Their goal for the second generation is to build off the 1st generation’s efficacy and duration by developing a more potent, more durable formulation, allowing for a 2-dose regiment (instead of 3-dose), resulting in higher and faster series completion. After evaluating adjuvants in formulation for their next-generation candidates, Pfizer noted they can increase the strength or magnitude of the immune response, potentially resulting in lower doses. Pfizer advanced 1 of the three updated 2nd-generation candidates to Phase 2 based on Phase 1/2 safety and immunogenicity data. The Phase 2 trial endpoints will evaluate the immunogenicity and safety of the 2-dose regimen. Trial data is expected in 2025, with a potential Phase 3 start in late 2025, pending positive results. Pfizer in Phase 2 is the furthest along of the C. diff vaccine assets. Idorsia Pharmaceuticals initiated Phase 1 for their competing C. diff asset in July. Vaxxilon and Matrivax Research & Development Corporation both have preclinical assets. GSK Plc’s GSK CDI vaccine completed a Phase 1 trial in 2022 but is no longer listed as a pipeline asset. Pfizer stock has dropped over 11.5% year-to-date. Investors can gain exposure to the stock through SPDR S&P 500 SPY and Vanguard S&P 500 ETF VOO . Price Action: PFE stock is up 0.82% at $26.58 at the last check on Monday. Also Read: Biden Administration Targets Chinese Firm Over Taiwan Semiconductor Chip Found in Huawei Tech Photo via Shutterstock © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
As he embarks on this new chapter in his footballing journey, the young midfielder is determined to make the most of this once-in-a-lifetime opportunity. He is eager to learn, grow, and develop his skills under the guidance of the club's experienced youth coaches and mentors. With his talent, determination, and unwavering passion for the game, he is poised to make a name for himself in the world of football.He is credited with strengthening counter-terrorism measures and creating the National Investigation Agency PTC Web Desk: Dr Manmohan Singh, during his tenure as Prime Minister of India from 2004 to 2014 and as Finance Minister in 1991, made several pivotal decisions that shaped India’s economic, social, and political landscape. Here are some of the most significant ones: As Finance Minister (1991-1996) Economic Liberalisation (1991): Decision: Opened up the Indian economy to foreign investments, reduced trade barriers, and deregulated industries. Impact: Transformed India from a closed economy to a globally competitive one, leading to rapid economic growth and foreign investment. Devaluation of the Rupee (1991) Decision: Drastically devalued the Indian rupee to address the balance of payments crisis. Impact: Boosted exports and improved India’s foreign reserves. Removal of Industrial Licensing (License Raj) Decision: Abolished the requirement for government approval for many industries. Impact: Encouraged entrepreneurship and industrial growth. Introduction of Tax Reforms: Decision: Streamlined direct and indirect taxes to improve compliance and broaden the tax base. Impact: Strengthened India’s fiscal framework. As Prime Minister (2004-2014) Economic Initiatives Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA): Decision: Launched a flagship scheme guaranteeing 100 days of employment to rural households. Impact: Alleviated rural poverty and created infrastructure in villages. Right to Information Act (2005): Decision: Empowered citizens by providing access to government records and decisions. Impact: Enhanced transparency and accountability in governance. Farm Loan Waiver (2008): Decision: Waived Rs 60,000 crore worth of loans for distressed farmers. Impact: Provided relief to millions of farmers but raised fiscal deficit concerns. Goods and Services Tax (GST) Framework: Decision: Initiated steps towards implementing a unified tax regime. Impact: Though implemented later, it laid the groundwork for tax reform. Foreign Policy and Strategic Decisions Indo-US Civil Nuclear Agreement (2008): Decision: Signed a landmark agreement with the US to allow civilian nuclear trade. Impact: Ended India’s nuclear isolation and bolstered its energy sector. Relations with Pakistan and China: Decision: Advocated for peace talks, including the 2004 composite dialogue with Pakistan and trade agreements with China. Impact: Fostered temporary goodwill but faced setbacks due to geopolitical tensions. Strengthening India’s Global Role: Decision: Played a leading role in G20 summits and global climate change negotiations. Impact: Elevated India’s standing as a major global player. Social and Welfare Initiatives Right to Education Act (2009): Decision: Made education a fundamental right for children aged 6 to 14. Impact: Improved access to education for millions. Food Security Act (2013): Decision: Introduced subsidized food for two-thirds of India’s population. Impact: Strengthened the safety net for underprivileged sections. Urban Development: Decision: Launched the Jawaharlal Nehru National Urban Renewal Mission (JNNURM). Impact: Improved urban infrastructure and governance. Defense and National Security Modernisation of Armed Forces: Decision: Increased defense spending and modernized the military with new acquisitions. Impact: Enhanced India's defense capabilities. Response to 26/11 Mumbai Attacks (2008): Decision: Strengthened counter-terrorism measures and created the National Investigation Agency (NIA). Impact: Improved domestic security framework. Challenges and Controversies 2G Spectrum and Coal Allocation Scandals: Though these scams tarnished his government’s image, Dr. Singh’s integrity was widely respected. Handling of the 2008 Global Financial Crisis: Decision: Implemented a stimulus package to revive growth. Impact: Helped India recover faster than most economies. - With inputs from agencies
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In a remarkable display of market fervor, both stock markets in China saw a surge in trading activity today, with a staggering 100 individual stocks hitting their daily limit up. This unprecedented event has sent shockwaves through the financial world, as investors and traders alike scramble to capitalize on the soaring market trends.Two Individuals Make Homemade Customs Declaration Forms to Ensure Safe Passage through Customs, Excessive Luxury Goods Discovered in Inspection( MENAFN - Caribbean News Global) KINGSTON, Jamaica – Caribbean countries need to urgently address the growing challenge of non-communicable diseases (NCDs). NCDs account for over 75 percent of all deaths in the region, with devastating economic consequences, including productivity losses and unsustainable healthcare costs. This critical message was emphasized by health experts from the World bank and regional health organizations during a public discussion as part of the Ask WBG Series . In countries like Barbados and Jamaica, NCDs lead to losses equivalent to 5.34 percent and 5.87 percent of GDP, respectively. Jamaica alone has seen $17.2 billion in lost economic output over 15 years. Without targeted interventions, the region faces rising premature deaths -40 percent of NCD-related deaths occur before age 70 – and escalating healthcare expenditures. “The current losses to economies from health care costs and lost productivity is massive and projected to increase exponentially as our populations age. The future of health in the Caribbean must be one where we act decisively to address non-communicable diseases and protect our economies” said Lilia Burunciuc, World Bank's country director for the Caribbean. The discussion shed light on critical gaps in NCD policies, with Caribbean nations implementing less than 40 percent of recommended measures. Priority areas for improvement include increasing taxes on tobacco and alcohol, restricting unhealthy food marketing, and promoting physical activity. No Caribbean country currently meets the WHO-recommended 75 percent tax share on tobacco. Dr Edit Velenyi, World Bank's senior economist, highlighted that investments in NCD prevention yield high returns. In Jamaica, for every $1 spent on NCD prevention, $2.1 is gained in healthcare savings and productivity, with potential GDP savings of 4.3 percent and 5,700 lives saved over 15 years. Experts offered a set of policy recommendations: The panel speakers included Dr Shana Cyr-Philbert, senior medical officer, ministry of health, wellness, and elderly affairs, Saint Lucia; Dr Kenneth Connell, president of the Healthy Caribbean Coalition; and Dr Heather Armstrong, head of the NCDs Unit at The Caribbean Public Health Agency. These experts shared their valuable insights on tackling the pressing issue of non-communicable diseases (NCDs) in the Caribbean. Recognizing the unique challenges of tackling NCDs in island nations, such as limited healthcare resources and geographic isolation, experts highlighted the critical role of innovative solutions in addressing these issues effectively. Innovations in technology, policy, and community-based approaches were emphasized as essential tools for overcoming these barriers. Experts also stressed that tackling the NCD challenge will require coordinated and collaborative efforts with partners and civil society organizations, not only at the national level but also across the entire region. The World Bank is working with the Caribbean governments to help countries address these challenges by focusing on areas such as improving health financing, enhancing health management information systems, strengthening care for non-communicable diseases, and boosting hospital sector performance. Through these efforts, the bank supports countries in their journey toward achieving universal health coverage and building resilient, efficient health systems tailored to the region's needs. The post NCDs account for between 1.4 – 8 percent of GDP loss in the Caribbean, says World Bank experts appeared first on Caribbean News Global . MENAFN17122024000232011072ID1109004889 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.
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Liu Dabeili's rise to fame was meteoric, with her social media accounts garnering millions of followers who were captivated by her flawless appearance and luxurious lifestyle. She was admired for her confidence and style, and many young people looked up to her as a role model for beauty and success.Telcos step up drive vs cyber threats, scams
One of the standout features of "Gluttony Chronicles" is its stunning visual presentation and mouth-watering culinary scenes. From breathtaking dessert creations to sumptuous banquet displays, the series showcases the artistry and craftsmanship behind the world of gastronomy, inviting viewers to savor every delectable moment on screen.Former Prime Minister Manmohan Singh died at AIIMS Delhi on Thursday evening. He breathed his last at 9:51 pm at the age of 92. This came hours after he was admitted to the emergency department of the hospital. The veteran leader, who had faced health issues in the past, was taken to the hospital for urgent medical attention. The news of his demise was first confirmed by Robert Vadra who posted it on social media. Later, a medical bulletin was also released by AIIMS, confirming Singh's (adsbygoogle = window.adsbygoogle || []).push({}); death. Dr Singh retired from the Rajya Sabha in April this year, marking the conclusion of a distinguished parliamentary career. Congress president Mallikarjun Kharge had lauded Singh's contributions and outlined his key role in shaping modern India's economic landscape. As the finance minister in the PV Narasimha Rao-led government from 1991-1996, Singh spearheaded transformative economic reforms, steering India away from socialist-era policies toward a liberalized economy.
The story of this missing woman, whose identity has been withheld for privacy reasons, gripped the nation as details of her unexpected return came to light. Many were shocked by the revelation that she had been living with Zhang for over a decade, completely unbeknownst to her family and friends. Questions arose about how such a situation could have unfolded and why she did not seek help or make her presence known earlier.It is evident that the opposition's skepticism towards the new government's proposed timeline for action is grounded in legitimate concerns and considerations. While the notion of immediate action may be appealing, it is essential to balance urgency with prudence and realism. Rushing into decisions and initiatives without proper planning and preparation could do more harm than good, potentially setting the government up for failure and disappointment.
NEW DELHI: Described as a “reluctant king” in his first stint as prime minister, the quietly spoken Manmohan Singh was arguably one of India’s most successful leaders. The first Sikh in office, Singh, 92, was being treated for age-related medical conditions and died after he was brought tohospital after a sudden loss of consciousness on Thursday. He is credited with steering India to unprecedented economicgrowth and lifting hundreds of millions out of dire poverty. Hewent on to serve a rare second term. Prime Minister Narendra Modi said: “India mourns the loss ofone of its most distinguished leaders, Dr. Manmohan Singh Ji.” He applauded the economist-turned-politician’s body of work. Born into a poor family in a part of British-ruled India now in Pakistan, Singh studied by candlelight to win a place at Cambridge University before heading to Oxford, earning a doctorate with a thesis on the role of exports and free trade in India’s economy. He became a respected economist, then India’s central bank governor and a government advisor but had no apparent plans for a political career when he was suddenly tapped to become finance minister in 1991. During that tenure to 1996, Singh was the architect of reforms that saved India’s economy from a severe balance of payments crisis, promoted deregulation and other measures that opened an insular country to the world. Famously quoting Victor Hugo in his maiden budget speech, he said: “No power on earth can stop an idea whose time has come,” before adding: “The emergence of India as a major economic power in the world happens to be one such idea.” Singh’s ascension to prime minister in 2004 was even more unexpected. He was asked to take on the job by Sonia Gandhi, who led the centre-left Congress party to a surprise victory. Italian by birth, she feared her ancestry would be used by Hindu-nationalist opponents to attack the government if she were to lead the country. Riding an unprecedented period of economic growth, Singh’s government shared the spoils of the country’s new found wealth, introducing welfare schemes such as a jobs programme for the rural poor. In 2008, his government also clinched a landmark deal that permitted peaceful trade in nuclear energy with the United States for the first time in three decades, paving the way for strong relations between New Delhi and Washington. But his efforts to further open up the Indian economy were frequently frustrated by political wrangling within his own party and demands made by coalition partners. “History will be kinder to me” And while he was widely respected by other world leaders, athome Singh always had to fend off the perception that SoniaGandhi was the real power in the government. The widow of former prime minister Rajiv Gandhi, whose family has dominated Indian politics since independence from Britain in 1947, she remained Congress party leader and often made key decisions. Known for his simple lifestyle and with a reputation for honesty, Singh was not personally seen as corrupt. But he came under attack for failing to crack down on members of his government as a series of scandals erupted in his second term, triggering mass protests. The latter years of his premiership saw India’s growth story, which he had helped engineer, wobble as global economic turbulence and slow government decision-making battered investment sentiment. In 2012, his government was tipped into a minority after the Congress party’s biggest ally quit their coalition in protest at the entry of foreign supermarkets. Two years later Congress was decisively swept aside by the Bharatiya Janata Party under Narendra Modi, a strongman who promised to end the economic standstill, clean up graft and bring inclusive growth to the hinterlands. But at a press conference just months before he left office, Singh insisted he had done the best he could. “I honestly believe that history will be kinder to me than the contemporary media or, for that matter, the opposition parties in parliament,” he said.KAIPING, China — Underneath a granite hill in southern China, a massive detector is nearly complete that will sniff out the mysterious ghost particles lurking around us. The Jiangmen Underground Neutrino Observatory will soon begin the difficult task of spotting neutrinos: tiny cosmic particles with a mind-bogglingly small mass. The detector is one of three being built across the globe to study these elusive ghost particles in the finest detail yet. The other two, based in the United States and Japan, are still under construction. Spying neutrinos is no small feat in the quest to understand how the universe came to be. The Chinese effort, set to go online next year, will push the technology to new limits, said Andre de Gouvea, a theoretical physicist at Northwestern University who is not involved with the project. “If they can pull that off,” he said, “it would be amazing.” Get the latest breaking news as it happens. By clicking Sign up, you agree to our privacy policy . What are neutrinos? Neutrinos date back to the Big Bang, and trillions zoom through our bodies every second. They spew from stars like the sun and stream out when atomic bits collide in a particle accelerator. Scientists have known about the existence of neutrinos for almost a century, but they’re still in the early stages of figuring out what the particles really are. “It’s the least understood particle in our world,” said Cao Jun, who helps manage the detector known as JUNO. "That’s why we need to study it.” There’s no way to spot the tiny neutrinos whizzing around on their own. Instead, scientists measure what happens when they collide with other bits of matter, producing flashes of light or charged particles. Neutrinos bump into other particles only very rarely, so to up their chances of catching a collision, physicists have to think big. “The solution for how we measure these neutrinos is to build very, very big detectors,” de Gouvea said. A big detector to measure tiny particles The $300 million detector in Kaiping, China, took over nine years to build. Its location 2,297 feet (700 meters) underground protects from pesky cosmic rays and radiation that could throw off its neutrino-sniffing abilities. On Wednesday, workers began the final step in construction. Eventually, they'll fill the orb-shaped detector with a liquid designed to emit light when neutrinos pass through and submerge the whole thing in purified water. It'll study antineutrinos — an opposite to neutrinos which allow scientists to understand their behavior — produced from collisions inside two nuclear power plants located over 31 miles (50 kilometers) away. When the antineutrinos come into contact with particles inside the detector, they'll produce a flash of light. The detector is specially designed to answer a key question about a longstanding mystery. Neutrinos switch between three flavors as they zip through space, and scientists want to rank them from lightest to heaviest. Sensing these subtle shifts in the already evasive particles will be a challenge, said Kate Scholberg, a physicist at Duke University who is not involved with the project. “It’s actually a very daring thing to even go after it,” she said. China’s detector is set to operate during the second half of next year. After that, it’ll take some time to collect and analyze the data — so scientists will have to keep waiting to fully unearth the secret lives of neutrinos. Two similar neutrino detectors – Japan’s Hyper-Kamiokande and the Deep Underground Neutrino Experiment based in the United States – are under construction. They’re set to go online around 2027 and 2031 and will cross-check the China detector’s results using different approaches. “In the end, we have a better understanding of the nature of physics,” said Wang Yifang, chief scientist and project manager of the Chinese effort. Understanding how the universe formed Though neutrinos barely interact with other particles, they’ve been around since the dawn of time. Studying these Big Bang relics can clue scientists into how the universe evolved and expanded billions of years ago. “They’re part of the big picture,” Scholberg said. One question researchers hope neutrinos can help answer is why the universe is overwhelmingly made up of matter with its opposing counterpart — called antimatter — largely snuffed out. Scientists don't know how things got to be so out of balance, but they think neutrinos could have helped write the earliest rules of matter. The proof, scientists say, may lie in the particles. They'll have to catch them to find out. ___ AP video producer Olivia Zhang contributed to this report. Ramakrishnan reported from New York.
Title: Chinese Foreign Ministry's Response to Allegations of Contact with Assad: Advocating for Stability in the Region