Protara Announces Proposed Public OfferingOn the brisk night, Santa arrived just in time, at the tail end of the two hour spectacle, for everyone to rush home, or out, and enjoy some hot chocolate.
WHIM Syndrome Pipeline Analysis 2024: FDA Approvals and Emerging Therapies, Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments | X4 Pharmaceuticals, NIAID
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The Secretary to the Government of the Federation (SGF), Senator George Akume, has commended President Bola Tinubu for taking decisive steps to implement the recommendations of the Oronsaye Report, a landmark document aimed at restructuring Nigeria’s public service. According to a statement by the director, information in SGF office, Segun Imohiosen, Senator Akume made the remarks during an interview on TVC’s ‘Politics on Sunday’, where he emphasised that the implementation of the report would end the duplication of functions among Ministries, Departments, and Agencies (MDAs), thereby ensuring greater efficiency and cost-effectiveness in governance. “The Oronsaye Report has been sitting idle since it was submitted to the previous government without action. However, President Tinubu has taken the bold step to commence implementation of parts of the report,” Akume noted. “This is a clear demonstration of the President’s commitment to reforming the public sector for the benefit of the government and the people.” He highlighted that policy decisions linked to the report were being fine-tuned to ensure a smooth implementation process, preventing any disruption to the system. “The focus is on avoiding overlaps and redundancies in government functions. These reforms are not arbitrary; they are meticulously designed to strengthen governance and ensure effective service delivery,” he said. Addressing broader governance issues, Senator Akume urged Nigerians to support President Tinubu’s vision for national prosperity. He called for unity in navigating the complex challenges facing the country, underscoring that sustainable solutions take time to develop. On other pressing issues, the SGF reaffirmed the government’s commitment to economic reforms, particularly the removal of fuel subsidies. He described the move as a necessary decision in the best interest of Nigerians. To cushion the impact, he pointed to initiatives such as the introduction of Compressed Natural Gas (CNG) buses and conversion kits as practical alternatives to stabilize the economy and ease the burden on citizens. Speaking on the long-standing issue of local government autonomy, Senator Akume revealed that a 10-man Inter-Ministerial Committee was working diligently to enforce the Supreme Court’s ruling on financial independence for local governments. He assured that their report would soon be submitted, paving the way for greater accountability and resource allocation at the grassroots level. Senator Akume appealed to Nigerians to rally behind the Tinubu administration’s reform agenda, describing it as pivotal to achieving lasting prosperity. “We must come together as a nation and support the President’s efforts to deliver on his mandate. The journey may be challenging, but the destination will undoubtedly benefit every Nigerian,” he said. The Oronsaye Report, submitted during the Goodluck Jonathan administration, has long been regarded as a blueprint for overhauling Nigeria’s sprawling and often inefficient public sector. Its gradual implementation under President Tinubu signals a renewed commitment to governance reform and national development. Also, Akume expressed unwavering support for the Tax Reforms Bills, describing it as visionary legislation designed to revamp Nigeria’s economy. Senator Akume emphasized that the current tax system is over 50 years in operation and fails to provide maximum benefits to Nigerians. He urged that comments on the bills should be assessed based on its intent, purpose, and credibility, rather than sectional or primordial feelings, citing its nationalistic and pro-poor in nature. “Solutions to complex problems are not as instant as instant coffee. The Federal Government and all tiers of governments have to come together to ensure prosperity in the land,” he noted.
River Hawks' road to national quarters marked by big playsLas Vegas, Dec 6 (PTI) A mission-driven workforce of tomorrow, energy efficiency driving innovation, and rise of AI-powered tools that accelerate fact-checking and debunk misinformation are among the top five tech prediction outlined by Amazon CTO Werner Vogels. According to him, in an era of unprecedented societal challenges and rapid technological advancements, harnessing 'technology for good' has become both an ethical imperative and a profitable endeavour. "From clean energy innovations unlocking new avenues for sustainable development to AI-powered tools tipping the scales in the fight against disinformation, we are witnessing technology augment human ingenuity in inspiring ways," he said. Emergence of workforce that is mission-driven, an era of energy efficiency driving innovation, and increasingly, technology tipping the scales in the discovery of truth are among his top tech predictions for 2025. "As disinformation spreads at unprecedented rates, a new wave of AI-powered tools will emerge to empower journalists, researchers, and engaged citizens in their quest for truth," he said. Vogels asserted this technological revolution will democratise investigative capabilities, accelerate fact-checking, as it closes the gap between the spread of misinformation and its debunking. He further observed that the rise of intention-driven technologies is reshaping people's relationship with the digital world, promoting focus and well-being over mere attention capture. "All the while, a mission-driven workforce is emerging, more eager to tackle hard human problems than chase the bottomline. In the coming years, using technology for positive impact will not just be possible — it will redefine the way we think about success," Vogels noted. As the world confronts urgent challenges around sustainability, social equity, food and economic security, and responsible AI usage, a quiet revolution is sweeping the job market, marking a shift towards "work that benefits humanity". Across industries and generations, there is a palpable shift in worker values and preferences, with a growing number of people seeking roles that allow them to make a meaningful impact on society and the environment. He argues that compared to previous generations, who were more concerned about personal freedom and economic growth, millennials and Gen Z typically show greater concern about issues like inequality, mental health, and climate change. "Organisations that recognise and harness this shift will be the ones that thrive in the decades to come," he said. To remain competitive, businesses across sectors must adapt their strategies to attract and retain purpose-driven employees. Vogels also sees open data driving decentralised disaster preparedness. By 2025 and beyond, disaster resilience will be fundamentally transformed through the power of hyperlocal, community-sourced data. This shift will redefine disaster management from a top-down, reactive model to one that is proactive, decentralised, and community-driven, he believes. The top executive of Amazon further sees intention-driven consumer technology taking hold. "A subtle shift is underway that is redefining our relationship with consumer technology. As more and more people look for a refuge from constant distraction, devices are emerging that prioritise mindfulness, intentionality, and deep thinking over a barrage of fleeting stimuli," says Vogels. In 2025 and beyond, technology will empower rather than distract, he says adding, "we’ll be better for it". PTI MBI (The PTI journalist was in Las Vegas at the invitation of Amazon Web Services) HIG MNK MNK
As we enter 2025 in a couple of days, we all know that the tech world is gearing up for major changes that will shake things up and affect our daily lives and how we run our businesses. These technological advancements are not just about making things faster or more connected; they also have much to do with big global challenges like climate change and cybersecurity. Artificial intelligence is on the verge of a significant transformation by 2025. For example, instead of relying solely on centralized servers, AI will start processing information from local devices like smartphones and gadgets. This shift will make everything run even faster. Scientists also say that we’ll see more agentic AI — autonomous systems that can make decisions on the ir own. Imagine AI optimizing supply chains based on real-time data, for example. Sustainability, which has taken the limelight these past years, will move even closer to center stage, driving more companies to focus on innovations that reduce environmental impact. We’ll also be seeing new waste management technologies and circular business models — where products are designed for reuse or recycling — as organizations aim for net-zero commitments. Additionally, AI will be used to drive the networks that optimize the distribution of energy across grids. It’s a marriage of renewable energy sources and smart technology, helping businesses to significantly lower their carbon footprints while boosting operational efficiency. In the world of quantum computing, actual applications across various fields will be seen this 2025, revolutionizing areas like drug discovery, climate modeling, and cybersecurity. As more organizations invest in quantum research and development, we might see significant advancements that change how we approach problem solving in science, finance, and logistics, among others. The Internet of Things (IoT) is expected to explode this coming year owing to 5G connectivity. The number of interconnected devices — from smart home gadgets to industrial sensors — is projected to reach billions! This allows businesses to gather vast amounts of real-time data from their operations, leading to better decision-making and greater efficiency. In smart cities, IoT applications will help manage traffic more effectively using real-time data analysis. Ambient computing envisions a world where digital devices seamlessly blend into our daily lives, operating quietly in the background without us having to think about them. Devices equipped with sensors and AI will understand our preferences automatically. In the world of work,, ambient computing could streamline workflows by anticipating needs. This trend will enhance user experiences and reduce the mental load of managing multiple devices or apps. As we embrace these exciting advancements on the horizon for 2025, we must remain vigilant and proactive in addressing the potential risks associated with these innovations. While the benefits are immense, they also bring challenges that require careful consideration. For instance, as AI systems become more autonomous, we must ensure robust ethical guidelines and regulatory frameworks are in place to prevent misuse and protect privacy. Similarly, with the rapid expansion of IoT devices, security measures must be strengthened to safeguard sensitive data from cyber threats. As we move toward a more sustainable future, we should also be mindful of the environmental impact of new technologies and prioritize circular economy practices to minimize waste. While we harness the power of technological advancements, we must make sure to safeguard our society and environment at the same time. Atty. Jose Ferdinand M. Rojas II received his Law degree from Ateneo de Manila University in 1994. He is currently engaged in the General Practice of Law through the firm he established, Jose M. Rojas Law Office. Prior to getting his Law degree, Atty. Rojas graduated Cum Laude in Economics and Political Science from the University of Massachusetts. He used to chair the Philippine Racing Commission (Philracom) and, more recently, used to sit as Vice-Chairman and General Manager of the Philippine Charity Sweepstakes Office (PCSO). Atty. Rojas is an opinion columnist for the Business Mirror and Pilipino Mirror, and 2014 awardee of People Asia’s “Men Who Matter.” He is a member of the Saturday Group of artists and is married to Atty. Patricia A.O. Bunye.Jimmy Carter, the 39th U.S. president, has died at 100
WHIM Syndrome Pipeline Analysis 2024: FDA Approvals and Emerging Therapies, Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments | X4 Pharmaceuticals, NIAIDThanksgiving never fails to deliver. Whether that's the mashed potatoes with the boatload of gravy on it, grandma's pecan pie, or the leftovers set to be consumed in the days following the holiday, it's a can't-miss event for most Americans on the calendar. Oh, and the football isn't bad either. The NFL rules as king on Thursday nights throughout the season, but when it comes to the last Thursday in November, it takes over the entire day. It's a three-game slate on the holiday, with the action starting early and continuing throughout the day, providing entertainment while friends and family gather to feast. While viewers are putting up numbers in their food consumption, there have been plenty of teams to put up impressive numbers on the field. Thanksgiving has seen its fair share of impressive offensive outputs. Who has scored the most points on Thanksgiving? Here is the full list of highest-scoring NFL games on the holiday. NFL HQ: Live NFL scores | Updated NFL standings | Full NFL schedule Most points scored in NFL Thanksgiving game Miami owns the record for the most points scored in a Thanksgiving game in the NFL. In 1977, the Dolphins walloped the St. Louis Cardinals 55-14 in St. Louis for the win. At the time, it set the franchise record for the most points scored by the team in a single game. That mark held for over 40 years until the 2023 Dolphins put up 70 points against the Broncos. That not only is the Miami record, but is tied for the second-most points ever scored by a team. MORE: How John Madden started NFL's Turkey Leg tradition Miami quarterback Bob Griese enjoyed a full, six-course meal against St. Louis. He finished the day with six passing touchdowns and 207 yards through the air, connecting with wide receiver Nat Moore three times for scores. Coupled with a ground game that put up 295 yards, the Dolphins totaled over 500 yards on offense, putting together the most impressive offensive showing in Thanksgiving NFL history. MORE: What teams always play on Thanksgiving? The Dolphins own the record for the most points scored on Thanksgiving, but they aren't the only club to put up a 50-burger on the holiday. There have been four teams total to score at least 50 points — the 1977 Dolphins, the 1927 Cleveland Bulldogs, the 1952 Lions and the 1980 Cowboys. Date Team Points Score Nov. 24, 1977 Miami Dolphins 55 Miami Dolphins 55, St. Louis Cardinals 14 Nov. 27, 1927 Cleveland Bulldogs 53 Cleveland Bulldogs 53, Milwaukee Badgers 10 Nov. 27, 1951 Detroit Lions 52 Detroit Lions 52 , Green Bay Packers 35 Nov. 27, 1980 Dallas Cowboys 51 Dallas Cowboys 51, Seattle Seahawks 7 Nov. 24, 1949 Detroit Lions 49 Detroit Lions 49, New York Yanks 14 Nov. 22, 2012 New England Patriots 49 New England Patriots 49, New York Jets 19 Nov. 27, 1952 Detroit Lions 48 Detroit Lions 48, Green Bay Packers 24 Nov. 27, 2008 Philadelphia Eagles 48 Philadelphia Eagles 48, Arizona Cardinals 20 Nov. 27, 2008 Tennessee Titans 47 Tennessee Titans 47 , Detroit Lions 10 Nov. 23, 1967 Dallas Cowboys 46 Dallas Cowboys 46, St. Louis Cardinals 21 Nov. 26, 1998 Minnesota Vikings 46 Minnesota Vikings 46, Dallas Cowboys 36 MORE: How John Madden popularized the turducken on NFL broadcasts Highest-scoring NFL Thanksgiving game The '51 Detroit squad was a part of the highest total for a Thanksgiving game. The Lions and Packers combined for 87 total points in the 52-35 win for Detroit. That's followed by the Packers-Lions slugfest in 1986, where Green Bay came out on top in a 44-40 thriller. The 84 total points rank second all-time in Thanksgiving history. One year later, the Vikings and Cowboys put up a combined 82 points in a 44-38 overtime win for Minnesota in 1987. The Vikings would tie that total mark two more times in the 1990s. A total of 82 points were scored in 1995 during a 44-38 loss to the Lions, and again in 1998 during a 46-36 win over the Cowboys. Date Score Total Points Nov. 27, 1951 Detroit Lions 52 , Green Bay Packers 35 87 Nov. 27, 1986 Green Bay Packers 44, Detroit Lions 40 84 Nov. 26, 1987 Minnesota Vikings 44, Dallas Cowboys 84 Nov. 23, 1995 Detroit Lions 44, Minnesota Vikings 38 82 Nov. 26, 1998 Minnesota Vikings 46, Dallas Cowboys 36 82
NEW YORK, Dec. 09, 2024 (GLOBE NEWSWIRE) -- Protara Therapeutics, Inc. (Nasdaq: TARA) (“Protara”), a clinical-stage company developing transformative therapies for the treatment of cancer and rare diseases, today announced that it has commenced an underwritten public offering of shares of its common stock or, in lieu of issuing common stock to certain investors, pre-funded warrants to purchase shares of its common stock. All of the shares of common stock and pre-funded warrants to be sold in the proposed offering will be offered by Protara. In addition, Protara expects to grant the underwriters a 30-day option to purchase additional shares of common stock at the public offering price, less underwriting discounts and commissions. The proposed offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or the actual size or terms of the offering. Protara intends to use the net proceeds received from the offering to fund the clinical development of TARA-002, as well as the development of other clinical programs. Protara may also use the net proceeds from the offering for working capital and other general corporate purposes. TD Cowen, Cantor, LifeSci Capital, Oppenheimer & Co. and Scotiabank are acting as joint book-running managers of the proposed offering. The shares of common stock and the pre-funded warrants will be issued pursuant to a shelf registration statement on Form S-3 (File No. 333-275290) that was declared effective on November 14, 2023 by the U.S. Securities and Exchange Commission (the “SEC”). The offering is being made only by means of a preliminary prospectus supplement and the accompanying prospectus. A preliminary prospectus supplement and the accompany prospectus relating to the offering will be filed with the SEC and will be available on the SEC’s website at www.sec.gov . Copies of the preliminary prospectus supplement and the accompany prospectus relating to the offering, when available, may be obtained from the offices of TD Securities (USA) LLC, 1 Vanderbilt Avenue, New York, New York 10017, by email at TD.ECM_Prospectus@tdsecurities.com or by telephone at (855) 495-9846; Cantor Fitzgerald & Co., 110 East 59th Street, 6th Floor, New York, New York 10022, Attention: Capital Markets, or by email at prospectus@cantor.com; or LifeSci Capital LLC, 1700 Broadway, 40th Floor, New York, New York 10019, or by email at compliance@lifescicapital.com. Before investing in the offering, interested parties should read the preliminary prospectus supplement and related prospectus for this offering, the documents incorporated by reference therein and the other documents Protara has filed with the Securities and Exchange Commission. The final terms of the offering will be disclosed in a final prospectus supplement to be filed with the Securities and Exchange Commission. This press release shall not constitute an offer to sell or a solicitation of an offer to buy any of these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the applicable securities laws of such state or jurisdiction. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are “forward looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Protara may, in some cases, use terms such as “predicts,” “believes,” “potential,” “proposed,” “continue,” “designed,” “estimates,” “anticipates,” “expects,” “plans,” “intends,” “may,” “could,” “might,” “will,” “should” or other words or expressions referencing future events, conditions or circumstances that convey uncertainty of future events or outcomes to identify these forward-looking statements. Such forward-looking statements include but are not limited to, statements regarding the timing, size and completion of the proposed public offering as well as the expected use of proceeds related thereto are not guarantees of future performance or results and involve substantial risks and uncertainties. Actual results, developments and events may differ materially from those in the forward-looking statements as a result of various factors including: Protara’s ability to complete the offering on the proposed terms, or at all, changes in market conditions, and Protara’s expectations related to the use of proceeds from the proposed offering. Additional important factors to be considered in connection with forward-looking statements, including additional risks and uncertainties, are described more fully under the caption “Risk Factors” and elsewhere in Protara’s filings and reports with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Protara undertakes no obligation to update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise, except as required by law. Company Contact: Justine O'Malley Protara Therapeutics Justine.OMalley@protaratx.com 646-817-2836Connected, brainy, athletic: the suspect in US insurance CEO's slayingHedge fund manager Scott Bessent is a credible, safe choice for US Treasury secretary -- and one that is likely positive for markets -- observers said Saturday following President-elect Donald Trump's highly anticipated nomination. His selection came after competition for the top economic job spilled into the open last weekend, with the world's richest man Elon Musk throwing his support instead behind Trump's transition team co-chair Howard Lutnick. Lutnick has since been named commerce secretary to lead Trump's tariff and trade agenda, and Bessent's nomination days later appears to be uncontroversial for now. "Scott Bessent is a credible, mainstream pick for Treasury Secretary," said Jason Furman, a professor at Harvard University and former top White House economic adviser. "I could see previous administrations as having chosen him," Furman, a former chair of the Council of Economic Advisers, told AFP. But a key difference is that Bessent, 62, has had to adopt and defend views on topics like tariffs, in a way "he never would have in pursuit of the job for a previous Republican administration." Tariffs are a key part of Trump's economic agenda, with the Republican president-elect vowing sweeping duties on allies and adversaries alike. In an opinion piece published earlier this month on Fox News, Bessent defended the potential use of tariffs as a means to raise revenue for the government, protect strategic US industries and negotiate with trading partners. He would be one of the first openly gay Cabinet officials if confirmed by the Senate, and the first at the helm of the Treasury Department. Jens Nordvig, chief executive of data and analytics firm Exante Data who has worked with Bessent, drew a contrast between his demeanor and that of other Trump supporters. While some Trump allies have a tendency towards "general sweeping statements," Bessent is an "analytical thinker, and he communicates accordingly," Nordvig told AFP. He counts Bessent among his early clients. "I would expect his messaging to be very focused, to get his key points across, without any unnecessary flamboyance or gusto," Nordvig added of the Wall Street veteran. Calling Bessent a "safe choice," Brookings senior fellow in economic studies David Wessel told AFP: "He will be an adult in the room for the Trump administration." Besides Bessent, others seen as top contenders for Treasury chief in recent days included former Federal Reserve governor Kevin Warsh, Apollo Global Management chief executive Marc Rowan, and Tennessee Senator Bill Hagerty. It remains to be seen if Bessent will be a big influence "moderating some of the administration's more aggressive trade policy" or simply be a spokesman, Wessel said. He does not have much experience in dealing with Congress either, and this would be important next year as the Trump administration works to raise the debt ceiling and effort a tax bill to deliver on his economic promises. Bessent would also have to grapple with the country's debt burden, with debt borrowed at much lower interest rates previously and Trump's plans estimated to add trillions over time. In an open letter published Saturday, Nordvig called for "thoughtful leadership" at the Treasury, saying a realistic approach to tax cuts and bond issuance was needed. He also sounded a hopeful note, saying Bessent would work to reduce extreme risks for markets. Krishna Guha, vice chairman of Evercore ISI, believes Bessent's nomination "will be well received by financial markets," given his deep understanding of markets and macro conditions. Guha also warned of the risk of bond yields spiking and "pushing up mortgage rates and tanking the housing market, while also causing stocks to sell off." In his past administration, Trump has viewed the stock market as a gauge of his success. bys/md
By FARNOUSH AMIRI, Associated Press WASHINGTON (AP) — Former Rep. Matt Gaetz said Friday that he will not be returning to Congress after withdrawing his name from consideration to be attorney general under President-elect Donald Trump amid growing allegations of sexual misconduct. “I’m still going to be in the fight, but it’s going to be from a new perch. I do not intend to join the 119th Congress,” Gaetz told conservative commentator Charlie Kirk, adding that he has “some other goals in life that I’m eager to pursue with my wife and my family.” The announcement comes a day after Gaetz, a Florida Republican, stepped aside from the Cabinet nomination process amid growing fallout from federal and House Ethics investigations that cast doubt on his ability to be confirmed as the nation’s chief federal law enforcement officer. The 42-year-old has vehemently denied the allegations against him. Gaetz’s nomination as attorney general had stunned many career lawyers inside the Justice Department, but reflected Trump’s desire to place a loyalist in a department he has marked for retribution following the criminal cases against him. Hours after Gaetz withdrew, Trump nominated Pam Bondi, the former Florida attorney general, who would come to the job with years of legal work under her belt and that other trait Trump prizes above all: loyalty. It’s unclear what’s next for Gaetz, who is no longer a member of the House. He surprised colleagues by resigning from Congress the same day that Trump nominated him for attorney general. Some speculated he could still be sworn into office for another two-year term on Jan. 3, given that he had just won reelection earlier this month. But Gaetz, who has been in state and national politics for 14 years, said he’s done with Congress. “I think that eight years is probably enough time in the United States Congress,” he said.China's anti-monopoly regulator announced Monday that it was investigating potential violations of antitrust law by Nvidia , the U.S. company that makes a vast majority of the computer chips that power artificial intelligence systems. The inquiry, a rare move by Beijing, comes a week after the Biden administration expanded curbs on the sale of advanced U.S. technology to China. In the days since, the Chinese government announced that it would ban the export of several rare minerals to the United States and imposed sanctions on more than a dozen U.S. defense firms and defense industry executives. Together, the moves by Beijing signal its willingness to engage in supply chain warfare as the policy contest over trade and the control of technology escalates between the world's two largest economies. The battle has made AI chips into one of the world's most sought-after technologies, and Nvidia has cornered the market, accounting for 90% of global sales by the end of last year. Nvidia's dominance helped it become one of the most valuable companies in the world over the past year. China's State Administration for Market Regulation said Monday that it was investigating Nvidia for violating commitments made during its acquisition of Mellanox Technologies, a company that makes computer networking equipment. The Chinese regulator approved Nvidia's acquisition of the company in 2020 with conditions to prevent anti-competitive practices and ensure supplies to China. 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"We work hard to provide the best products we can in every region and honor our commitments everywhere we do business," the statement said. Discover the stories of your interest Blockchain 5 Stories Cyber-safety 7 Stories Fintech 9 Stories E-comm 9 Stories ML 8 Stories Edtech 6 Stories As the Biden administration has progressively tightened restrictions on Nvidia's chip sales to China, the company has responded by offering less powerful versions of its chips to the Chinese market. Officials in Washington, in trying to prevent Chinese companies from buying advanced chips and the machines to make them, say that the technology is essential not just for smartphones and chatbots but also for military superiority. Chinese tech companies have resorted to stockpiling the chips, while also turning to smugglers and front companies to secure supplies. At the same time, Beijing is pouring large sums of money into its own chip companies in an attempt to make its tech sector less reliant on foreign technology.FBI director says he intends to resign at end of Joe Biden’s termJoe Burrow addresses Bengals' 4-7 record ahead of game against Pittsburgh
Longest-lived US president was always happy to speak his mindAP Trending SummaryBrief at 1:56 p.m. ESTThe fun is never gone on Fox
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