Robot umpires are officially knocking on the door of MLB. Commissioner Rob Manfred told The Athletic's Evan Drellich on Wednesday that the league will test an automated ball-strike challenge system at spring training in 2025, with the hope the system can be implemented in the regular season in 2026. The system will reportedly give give teams two challenges per game, retaining them when they are correct. Not every spring training ballpark will reportedly have the ABS cameras, but all teams will have the opportunity to play with it. From The Athletic: “I think we will have a spring training ABS test that will provide a meaningful opportunity for all major-league players to see what the challenge system will look like,” Manfred said. “From my perspective, there’s two sides to that test: It’s what clubs think about it, and also, what do the players think about it? And we’re gonna have to sort through both of those.” MLB has experimented with ABS systems in the minor leagues going back to 2019, in two formats. Some games have seen the robo umps used to call every pitch, while others have used the challenge system about to hit spring training. The challenge system was used full-time in Triple-A, and you can see it used to end a game here: Upon further review... win it! prospect Hayden Harris records all of his outs via strikeout to earn the save -- with the final one coming on an ABS challenge: — Minor League Baseball (@MiLB) At one point last year, . Robo umps once felt like a radical change for MLB, but they've become something of an inevitably because of how MLB has approached them. Because they've been around the minor leagues for years, an enormous chunk of current major leaguers already have experience with the system. It has been a very slow transition for the league, but it appears to almost be over. There will almost certainly be grumbles with the system (not every pitch that is technically a strike looks like a strike, and the same with balls), but many fans will take it over a human element that can be infuriating at times.
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LUBBOCK, Texas (AP) — Tahj Brooks ran for a season-high 188 yards and three touchdowns in the final home game for Texas Tech's all-time leading rusher, and the Red Raiders rolled to a 52-15 victory over West Virginia on Saturday. Texas Tech (8-4, 6-3 Big 12) kept alive faint hopes for a bid in the Big 12 championship game by winning at least eight games in the regular season for the first time since 2009 under the late Mike Leach. The Red Raiders scored at 50 points for the second week in a row and had a resounding response to consecutive home losses. “It was a big deal for us to play well at home,” coach Joey McGuire said. “Our last two home games, we’ve had incredible crowds that had great energy, that had our backs and we played really, really bad. We were embarrassed.” Garrett Greene threw an interception and lost a fumble on Terrell Tilmon's strip sack in the final three minutes of the first half as the Mountaineers (6-6, 5-4) raised more questions about the future of coach Neal Brown by falling behind 35-3 before the break. Behren Morton threw for 359 yards and two touchdowns, including a 31-yarder to Caleb Douglas to put Texas Tech in front 42-3 early in the second half. Josh Kelly had 150 yards receiving. “I don’t think the first half of football defines who they are, who they are as individuals, who we are as a team,” Brown said of the Mountaineers. “Not pleased with that.” McGuire, who will have his third winning record in three seasons, called timeout with 5:57 remaining and his team leading 45-15 to take Brooks out of the game. Brooks was mobbed by teammates as the crowd gave him a standing ovation. Brooks ran for at least 100 yards in all 11 regular-season games he played, breaking the single-season school record of 10 he shared with Byron Hanspard and Bam Morris. Brooks pushed his career total to 4,557 yards in his first home game since breaking Hanspard's 1996 school record of 4,219 yards two weeks ago at Jones AT&T Stadium. Two of Brooks' TDs came on 2-yard runs from direct snaps, and the other was a 37-yarder when he stumbled on a cut but stayed on his feet and bounced off defensive back Ty French. Brooks has 17 TDs rushing this season and 45 for his career. Brooks set up one of his short TDs with a 30-yard catch. Jahiem White ran for 124 yards with a spinning 21-yard touchdown for West Virginia, and Greene had a 15-yard scoring toss to Rodney Gallagher III. Greene threw two picks. West Virginia: A perfect season on the road in the Big 12 ended with a thud. The Mountaineers were 3-0 away from home in conference before allowing 29 second-quarter points followed by another TD just 2:12 into the third. Texas Tech: Tight end Jalin Conyers, one of Brooks' fellow seniors playing his final home game, made up a for a dropped pass in the end zone with a juggling, diving catch for 18 yards to set up Morton's 1-yard scoring toss to Mason Tharp. Conyers, an Arizona State transfer, also had a 2-point conversion run on a swinging gate play from the PAT unit. Both teams are eligible for bowl games. At game's end, Texas Tech's fate for a spot in the Big 12 title game was still up in the air. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-footballElection battlelines are being drawn – and not by AlbaneseFort Worth’s major hospitals are transforming to keep up with growth. Here’s what to expect
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OSAKA, Japan and MONTREAL , Dec. 5, 2024 /PRNewswire/ -- Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan ; President: Toichi Takino; "Ono") announced that it has entered into a drug discovery collaboration agreement with Congruence Therapeutics (Headquarters: Montreal, Quebec, Canada ; CEO: Clarissa Desjardins; "Congruence") to generate novel small molecule correctors against multiple protein targets in the oncology area by leveraging Congruence's proprietary drug discovery platform, RevenirTM. Under the terms of the agreement, Congruence will generate small molecule correctors by leveraging Congruence's proprietary drug discovery engine called, RevenirTM. Ono will obtain an exclusive option right to develop, manufacture and commercialize the identified small molecule correctors worldwide. Congruence will be eligible to receive an upfront payment, research expenses, milestone payments based on research and development progress and sales, as well as tiered royalties based on net sales. "We believe that this collaboration with Congruence may help generating novel small molecule correctors for validated targets in the oncology area by leveraging their own technologies in protein dynamics and computational biology, leading to our development pipeline," said Seishi Katsumata , Corporate Officer / Executive Director, Discovery & Research of Ono. "We will be committed to delivering innovative new drugs to cancer patients as soon as possible." "Congruence is thrilled to partner with Ono, which has established itself as a global leader in drug development, particularly in the oncology space. We believe that our RevenirTM platform and capabilities in protein dynamics will accelerate the discovery of novel therapies for compelling targets of interest to both companies," said Sharath Hegde PhD, Chief Scientific Officer of Congruence. About RevenirTM Drug Discovery Platform RevenirTM, Congruence's proprietary computational drug discovery platform, captures the dynamic biophysical changes caused by mutations in proteins, offering unique insights into protein defects and their correction. By examining surface features and a spectrum of biophysical descriptors across an ensemble of protein conformers, RevenirTM predicts small molecule induced correction of the underlying defect. About Congruence Therapeutics Congruence is a computationally-driven biotechnology company building a unique pipeline of transformative small molecule correctors rationally designed to rescue aberrant protein function. Congruence's proprietary scalable platform, RevenirTM, captures the biophysical features of proteins across their conformational ensembles, in order to identify novel allosteric and cryptic pockets which are virtually screened to generate novel chemical matter. For more information, please visit www.congruencetx.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/ono-enters-into-drug-discovery-collaboration-agreement-with-congruence-therapeutics-to-generate-novel-small-molecule-correctors-in-the-oncology-area-302324452.html SOURCE Ono Pharmaceutical co., ltd.It’s not hard to understand the value tight end Josh Oliver brings to the Vikings. Just listen to the way people talk about him. “He’s an animal,” tight end T.J. Hockenson said. “Once he gets his hands on somebody, it’s kind of like, ‘Good luck.'” It was similar sentiment from offensive coordinator Wes Phillips. “He’s the best blocking tight end in the league, and that’s no disrespect to anybody else,” Phillips said. “We will take Josh over anybody in this league in the role that he’s in. It’s not only that he’s physically imposing as a 270-pound man. It’s the attitude that he plays with out there.” What are the Vikings losing now that Oliver has been ruled out with an ankle injury? His absence will be felt most when the Vikings try to run the ball against the Chicago Bears on Sunday afternoon at Soldier Field. Though he has proved he can contribute in the passing game, Oliver has been a force in the running game since signing with the Vikings. There have been multiple times this season that Oliver had singlehandedly carved out space for running back Aaron Jones to go to work. That’s partially why Hockenson has played only about 50% of the offensive snaps since returning from a torn anterior cruciate ligament a few weeks ago. Even if the Vikings are often telegraphing a run when Oliver is on the field, they don’t care because they feel that strongly about his ability as a blocker. “You see it every single week,” Phillips said. “He’s moving large men and putting them on the ground.” It’s safe to assume Oliver would suit up for the Vikings if he were able to do so. He’s been playing through a wrist injury for the past few weeks, for example, and has still been extremely effective at the point of attack. How tough is it to replace Oliver in a vacuum? “It’s a big challenge because of all the things he does on a snap in and snap out basis,” head coach Kevin O’Connell said. “We will see some guys make some impacts on some different downs and distances than we have maybe seen up to this point.” The only other players on the injury report for the Vikings are tight end Nick Muse (hand) and edge rusher Gabe Murphy (knee). Both players were officially listed as questionable and being full participants in the walkthrough on Friday afternoon at TCO Performance Center.22,847 Shares in VICI Properties Inc. (NYSE:VICI) Acquired by B. Metzler seel. Sohn & Co. Holding AG