Stock indexes drifted to a mixed finish on Wall Street as some heavyweight technology and communications sector stocks offset gains elsewhere in the market. The S&P 500 slipped less than 0.1% Thursday, its first loss after three straight gains. The Dow Jones Industrial Average added 0.1%, and the Nasdaq composite fell 0.1%. Gains by retailers and health care stocks helped temper the losses. Trading volume was lighter than usual as U.S. markets reopened following the Christmas holiday. The Labor Department reported that U.S. applications for unemployment benefits held steady last week, though continuing claims rose to the highest level in three years. Treasury yields fell in the bond market. On Thursday: Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Get updates and player profiles ahead of Friday's high school games, plus a recap Saturday with stories, photos, video Frequency: Seasonal Twice a weekAs part of a national “moonshot” to cure blindness, researchers at the CU Anschutz Medical Campus will receive as much as $46 million in federal funding over the next five years to pursue a first-of-its-kind full eye transplantation. “This is no easy undertaking, but I believe we can achieve this together,” said Dr. Kia Washington, the lead researcher for the University of Colorado-led team, during a press conference Monday. “And in fact I’ve never been more hopeful that a cure for blindness is within reach.” The CU team was one of four in the United States that received funding awards from the federal Advanced Research Projects Agency for Health , or ARPA-H. The CU-based group will focus on achieving the first-ever vision-restoring eye transplant by using “novel stem cell and bioelectronic technologies,” according to a news release announcing the funding. The work will be interdisciplinary, Washington and others said, and will link together researchers at institutions across the country. The four teams that received the funding will work alongside each other on distinct approaches, though officials said the teams would likely collaborate and eventually may merge depending on which research avenues show the most promise toward achieving the ultimate goal of transplanting an eye and curing blindness. Dr. Calvin Roberts, who will oversee the broader project for ARPA-H, said the agency wanted to take multiple “shots on goal” to ensure progress. “In the broader picture, achieving this would be probably the most monumental task in medicine within the last several decades,” said Dr. Daniel Pelaez of the University of Miami’s Bascom Palmer Eye Institute, which also received ARPA-H funding. Pelaez is the lead investigator for that team, which has pursued new procedures to successfully remove and preserve eyes from donors, amid other research. He told The Denver Post that only four organ systems have not been successfully transplanted: the inner ear, the brain, the spinal cord and the eye. All four are part of the central nervous system, which does not repair itself when damaged. If researchers can successfully transplant the human eye and restore vision to the patient, it might help unlock deeper discoveries about repairing damage to the brain and spine, Pelaez said, as well as addressing hearing loss. To succeed, researchers must successfully remove and preserve eyes from donors and then successfully connect and repair the optical nerve, which takes information from the eye and tells the brain what the eye sees. A team at New York University performed a full eye transplant on a human patient in November 2023, though the procedure — while a “remarkable achievement,” Pelaez said — did not restore the patient’s vision. It was also part of a partial face transplant; other approaches pursued via the ARPA-H funding will involve eye-specific transplants. Washington, the lead CU researcher, said she and her colleagues have already completed the eye transplant procedure — albeit without vision restoration — in rats. The CU team will next work on large animals to advance “optic nerve regenerative strategies,” the school said, as well as to study immunosuppression, which is critical to ensuring that patients’ immune systems don’t reject a donated organ. The goal is to eventually advance to human trials. Pelaez and his colleagues have completed their eye-removal procedure in cadavers, he said, and they’ve also studied regeneration in several animals that are capable of regenerating parts of their eyes, like salamanders or zebra fish. His team’s funding will focus in part on a life-support machine for the eye to keep it healthy and viable during the removal process. InGel Therapeutics, a Massachusetts-based Harvard spinoff and the lead of a third team, will pursue research on 3-D printed technology and “micro-tunneled scaffolds” that carry certain types of stem cells as part of a focus on optical nerve regeneration and repair, ARPA-H said. ARPH-A, created two years ago, will oversee the teams’ work. Researchers at 52 institutions nationwide will also contribute to the teams. The CU-led group will include researchers from the University of Southern California, the University of Wisconsin, Indiana University and Johns Hopkins University, as well as from the National Eye Institute . The teams will simultaneously compete and collaborate: Pelaez said his team has communicated with researchers at CU and at Stanford, another award recipient, about their eye-removal research. The total funding available for the teams is $125 million, ARPA-H officials said Monday, and it will be distributed in phases, in part dependent on teams’ success. U.S. Rep. Diana DeGette, a Democrat who represents Denver in Congress, acknowledged the recent election results at the press conference Monday and pledged to continue fighting to preserve ARPA-H’s funding under President-elect Donald Trump’s administration. The effort to cure blindness, Washington joked, was “biblical” in its enormity — a reference to the Bible story in which Jesus cures a blind man. She and others also likened it to a moonshot, meaning the effort to successfully put Neil Armstrong and Buzz Aldrin on the moon nearly 50 years ago. If curing blindness is similar to landing on the moon, then the space shuttle has already left the launchpad, Washington said. “We have launched,” she said, “and we are on our trajectory.”
Macron to name new French PM Friday after days of deadlockBlessings for the children
Brazil shares higher at close of trade; Bovespa up 1.40%Few people in politics inspire the kind of respect Sardar Manmohan Singh did PriyankaChelsea’s surprise defeat at home to Fulham earlier in the day had been an unexpected gift for Arne Slot’s side and they drove home their advantage by outclassing the struggling Foxes. Having overcome the early setback of conceding to Jordan Ayew, with even the travelling fans expressing their surprise they were winning away after taking just five points on the road this season, the home team had too much quality. That was personified by the excellent Cody Gakpo, whose eighth goal in his last 14 appearances produced the equaliser in first-half added time with the Netherlands international unlucky to have a second ruled out for offside by VAR. Further goals from Curtis Jones and Mohamed Salah, with his 19th of the season, stretched Liverpool’s unbeaten run to 22 matches. For Leicester, who had slipped into the bottom three after Wolves’ win over Manchester United, it is now one win from the last 10 in the league and Ruud van Nistelrooy has plenty of work to do, although he was not helped here by the absence of leading scorer Jamie Vardy through injury. It looked liked Liverpool meant business from the off with Salah’s volley from Gakpo’s far-post cross just being kept out by Jakub Stolarczyk, making his league debut after former Liverpool goalkeeper Danny Ward was omitted from the squad having struggled in the defeat to Wolves. But if the hosts thought that had set the tone they were badly mistaken after being opened up with such simplicity in only the sixth minute. Stephy Mavididi broke down the left and his low cross picked out Ayew, who turned Andy Robertson far too easily, with his shot deflecting off Virgil van Dijk to take it just out of Alisson Becker’s reach. With a surprise lead to cling to Leicester knew they had to quell the storm heading their way and they began by trying to take as much time out of the game as they could, much to Anfield’s frustration. It took a further 18 minutes for Liverpool to threaten with Gakpo cutting in from the left to fire over, a precursor for what was to follow just before half-time. That was the prompt for the attacks to rain down on the Foxes goal, with Salah’s shot looping up off Victor Kristiansen and landing on the roof of the net and Robertson heading against a post. Gakpo’s inclination to come in off the left was proving a problem for the visitors, doing their utmost to resist the pressure, but when Salah curled a shot onto the crossbar on the stroke of half-time it appeared they had survived. However, Gakpo once again drifted in off the flank to collect an Alexis Mac Allister pass before curling what is fast becoming his trademark effort over Stolarczyk and inside the far post. Early the second half Darwin Nunez fired over Ryan Gravenberch’s cross before Jones side-footed home Mac Allister’s cross after an intricate passing move inside the penalty area involving Nunez, Salah and the Argentina international. Leicester’s ambition remained limited but Patson Daka should have done better from a two-on-one counter attack with Mavididi but completely missed his kick with the goal looming. Nunez forced a save out of the goalkeeper before Gakpo blasted home what he thought was his second only for VAR to rule Nunez was offside in the build-up. But Liverpool’s third was eventually delivered by the left foot of Salah, who curled the ball outside Kristiansen, inside Jannick Vestergaard and past Stolarczyk inside the far post.The tax regime that replaced that of non-habitual residents, IFICI+, covers eight professions considered to be "highly qualified", according to the ordinance published in the Official Gazette of the Union. In this ordinance, the Government regulates the registration of beneficiaries in the aforementioned IFICI+ as well as the lists of highly qualified professions and planned industrial and service activities. The "highly qualified professions" for the purposes of tax incentives for scientific research and innovation are then those that fall under the following codes: - general director and executive manager of companies; - directors of administrative and commercial services; - directors of production and specialized services; - specialists in physical, mathematical sciences, engineering and related techniques; - ‘designer’ of industrial product or equipment; - doctors; - professor of university and higher education; - and specialists in information and communication technologies (ICT). As had already been said by the Minister of Economy, there is a transitional regime, "for the purposes of applying this regime to income earned in the year 2024", which allows anyone who becomes resident in Portuguese territory this year to submit an application for registration and report changes by March 15, 2025. In this first year of IFICI+ operation, interested parties will be able to register until March 15th, but in the future the deadline for registration will be January 15th (for those who became residents in the immediately previous year). At issue is a new tax regime for attracting qualified workers, particularly in the areas of scientific research, to whom an IRS rate of 20% will be applied to income from dependent and independent work (categories A and B).
How the stock market defied expectations again this year, by the numbers NEW YORK (AP) — What a wonderful year 2024 has been for investors. U.S. stocks ripped higher and carried the S&P 500 to records as the economy kept growing and the Federal Reserve began cutting interest rates. The benchmark index posted its first back-to-back annual gains of more than 20% since 1998. The year featured many familiar winners, such as Big Tech, which got even bigger as their stock prices kept growing. But it wasn’t just Apple, Nvidia and the like. Bitcoin and gold surged and “Roaring Kitty” reappeared to briefly reignite the meme stock craze. Stock market today: Wall Street drifts to a mixed close in thin trading following a holiday pause Stock indexes drifted to a mixed finish on Wall Street as some heavyweight technology and communications sector stocks offset gains elsewhere in the market. The S&P 500 slipped less than 0.1% Thursday, its first loss after three straight gains. The Dow Jones Industrial Average added 0.1%, and the Nasdaq composite fell 0.1%. Gains by retailers and health care stocks helped temper the losses. Trading volume was lighter than usual as U.S. markets reopened following the Christmas holiday. The Labor Department reported that U.S. applications for unemployment benefits held steady last week, though continuing claims rose to the highest level in three years. Treasury yields fell in the bond market. Israel strikes Houthi rebels in Yemen's capital while the WHO chief says he was meters away JERUSALEM (AP) — A new round of Israeli airstrikes in Yemen has targeted the Houthi rebel-held capital of Sanaa and multiple ports. The World Health Organization’s director-general said Thursday's bombardment took place just “meters away” as he was about to board a flight in Sanaa. He says a crew member was hurt. The strikes followed several days of Houthi attacks and launches setting off sirens in Israel. Israel's military says it attacked infrastructure used by the Houthis at the airport in Sanaa, power stations and ports. The Israeli military later said it wasn’t aware that the WHO chief was at the location in Yemen. At least three people were reported killed and dozens injured in the Sanaa airport strike. Holiday shoppers increased spending by 3.8% despite higher prices New data shows holiday sales rose this year even as Americans wrestled with still high prices in many grocery necessities and other financial worries. According to Mastercard SpendingPulse, holiday sales from the beginning of November through Christmas Eve climbed 3.8%, a faster pace than the 3.1% increase from a year earlier. The measure tracks all kinds of payments including cash and debit cards. This year, retailers were even more under the gun to get shoppers in to buy early and in bulk since there were five fewer days between Thanksgiving and Christmas. Mastercard SpendingPulse says the last five days of the season accounted for 10% of the spending. Sales of clothing, electronics and Jewelry rose. Finland stops Russia-linked vessel over damaged undersea power cable in Baltic Sea FRANKFURT, Germany (AP) — Finnish police say authorities detained a ship linked to neighboring Russia as they investigate whether it damaged a Baltic Sea power cable and several data cables. It was the latest incident involving disruption of key infrastructure. Police and border guards boarded the Eagle S and took control as they investigate damage to the Estlink-2 undersea power cable. The cable brings electricity from Finland to Estonia across the Baltic Sea. The cable went down on Wednesday. The incident follows damage to two data cables and the Nord Stream gas pipelines. Both have been termed sabotage. Russian ship that sank in the Mediterranean was attacked, owner says MOSCOW (AP) — The Russian operator of a cargo ship that sank in the Mediterranean Sea between Spain and Algeria says it has been hit by a series of explosions in an act of sabotage. Oboronlogistica is a state-controlled company that operated the Ursa Major freighter. The company said the vessel was wrecked by three powerful explosions just above the water line in what it described as a “terrorist attack” that caused it to sink on Monday. The company said in a statement carried by Russia’s state RIA Novosti news agency on Thursday that the explosions left a hole in the ship’s starboard and filled the engine room with acrid smoke. That hampered the crew’s attempts to access it. Undersea power cable linking Finland and Estonia hit by outage, prompting investigation FRANKFURT, Germany (AP) — Finland’s prime minister says authorities are investigating an interruption in a power cable under the Baltic Sea between his country and Estonia. Petteri Orpo said on X that power transmission through the Estlink-2 cable suffered an outage Wednesday. Authorities have been on edge about undersea infrastructure in the Baltic after two international data cables were severed in November and the Nord Stream gas pipelines between Russia and Germany were blown up in September 2022. Japan to maximize nuclear power in clean-energy push as electricity demand grows TOKYO (AP) — A Japanese government panel has largely supported a draft energy policy calling for bolstering renewables up to half of Japanese electricity needs by 2040. It also recommends maximizing the use of nuclear power to accommodate the growing demand for power in the era of AI while meeting decarbonization targets. Cabinet is expected to formally approve the plan by March following a period of public consultation. The policy says nuclear energy should account for 20% of Japan’s energy supply in 2040, with renewables expanded to 40-50% and coal-fired power reduced to 30-40%. Working Well: Returning to the office can disrupt life. Here are some tips to navigate the changes NEW YORK (AP) — Thousands of workers are facing an unsettling reality heading into 2025. After years of working from the comfort of home, they're being told it’s time to return to the office full-time for the first time since the coronavirus pandemic. That can bring a host of challenges, including losing time with family. Workers at Amazon, AT&T and other companies have been called back to the office five days a week. Experts have advice to share about how to navigate the changes when an employer calls you back to the office. Workers can convey what they need, seek flexibility and if all else fails, consider other options. FDA proposes new testing rules to ensure cosmetics are asbestos-free WASHINGTON (AP) — The Food and Drug Administration is proposing a rule that cosmetic companies would have to take extra steps to ensure that any products containing talc are free of asbestos. The rule was proposed Thursday and is intended to reassure consumers about the safety of makeup, baby powder and other personal care products. The rule follows years of lawsuits against Johnson & Johnson and other companies alleging links between talc-based baby powder and cancer. Research has found mixed evidence of a potential link between cancer and talc, although the possibility has been recognized for decades because of how it is mined.
Premier League leaders Liverpool ruthlessly exploited another slip by their title rivals to move seven points clear with a match in hand after a 3-1 win over Leicester. Chelsea’s surprise defeat at home to Fulham earlier in the day had been an unexpected gift for Arne Slot’s side and they drove home their advantage by outclassing the struggling Foxes. Having overcome the early setback of conceding to Jordan Ayew, with even the travelling fans expressing their surprise they were winning away after taking just five points on the road this season, the home team had too much quality. That was personified by the excellent Cody Gakpo, whose eighth goal in his last 14 appearances produced the equaliser in first-half added time with the Netherlands international unlucky to have a second ruled out for offside by VAR. Further goals from Curtis Jones and Mohamed Salah, with his 19th of the season, stretched Liverpool’s unbeaten run to 22 matches. For Leicester, who had slipped into the bottom three after Wolves’ win over Manchester United, it is now one win from the last 10 in the league and Ruud van Nistelrooy has plenty of work to do, although he was not helped here by the absence of leading scorer Jamie Vardy through injury. It looked liked Liverpool meant business from the off with Salah’s volley from Gakpo’s far-post cross just being kept out by Jakub Stolarczyk, making his league debut after former Liverpool goalkeeper Danny Ward was omitted from the squad having struggled in the defeat to Wolves. But if the hosts thought that had set the tone they were badly mistaken after being opened up with such simplicity in only the sixth minute. Stephy Mavididi broke down the left and his low cross picked out Ayew, who turned Andy Robertson far too easily, with his shot deflecting off Virgil van Dijk to take it just out of Alisson Becker’s reach. With a surprise lead to cling to Leicester knew they had to quell the storm heading their way and they began by trying to take as much time out of the game as they could, much to Anfield’s frustration. It took a further 18 minutes for Liverpool to threaten with Gakpo cutting in from the left to fire over, a precursor for what was to follow just before half-time. That was the prompt for the attacks to rain down on the Foxes goal, with Salah’s shot looping up off Victor Kristiansen and landing on the roof of the net and Robertson heading against a post. Gakpo’s inclination to come in off the left was proving a problem for the visitors, doing their utmost to resist the pressure, but when Salah curled a shot onto the crossbar on the stroke of half-time it appeared they had survived. However, Gakpo once again drifted in off the flank to collect an Alexis Mac Allister pass before curling what is fast becoming his trademark effort over Stolarczyk and inside the far post. Early the second half Darwin Nunez fired over Ryan Gravenberch’s cross before Jones side-footed home Mac Allister’s cross after an intricate passing move inside the penalty area involving Nunez, Salah and the Argentina international. Leicester’s ambition remained limited but Patson Daka should have done better from a two-on-one counter attack with Mavididi but completely missed his kick with the goal looming. 🎯 — Liverpool FC (@LFC) Nunez forced a save out of the goalkeeper before Gakpo blasted home what he thought was his second only for VAR to rule Nunez was offside in the build-up. But Liverpool’s third was eventually delivered by the left foot of Salah, who curled the ball outside Kristiansen, inside Jannick Vestergaard and past Stolarczyk inside the far post.
Imphal: Two days after the Ministry of Home Affairs (MHA) introduced a border pass system for Indian and Myanmar nationals residing within 10 km along the international borders, allowing limited entry into either territory for specific purposes, apex body of majority Meitei community in Manipur on Thursday strongly opposed the notification. The Coordinating Committee on Manipur Integrity (COCOMI), an umbrella body of the majority Meitei community in Manipur termed the MHA notification of December 24, unfortunate and said that it would harm the interest of the state and its people. Describing MHA notification as a threat to Manipur’s security and communal harmony, COCOMI Media Coordinator Yumkhaibam Surjit Kumar Khuman on Wednesday accused the Assam Rifles of “bias and of facilitating illegal activities.” He urged the withdrawal of the notification, saying that such measures would compromise the state’s integrity. “Already Chin-Kuki narco-terrorists and infiltrators from Myanmar damaged a lot of Manipur and harmed the interest of the people, such an order would further spoil the security, integrity and social harmony of the state,” the COCOMI leader said. The MHA in a letter to the state Chief Secretary Vineet Joshi on December 24 said that it has introduced a border pass system for Myanmar nationals residing within 10 km of the India-Myanmar border, allowing limited entry into Manipur for specific purposes. The scheme, communicated to the Manipur government, replaces the previously suspended Free Movement Regime (FMR) and also applies to Manipur residents residing within 10 km of the border visiting Myanmar. Under the scheme, the Assam Rifles would issue border passes valid for one week for specific purposes such as visiting relatives, tourism, business, medical needs, sports, official duty, border trade affairs, attendance in seminars or conferences and cultural exchange programmes. Travellers would be required to provide proof of identity and residence, and movement would be strictly regulated within 10 km of the border, the MHA notification said adding that “movement of people from 43 designated crossing points would be granted to holders of ‘Border Pass’ issued by authorised representatives of Assam Rifles.” According to the MHA notification, the Border Pass would be issued only to one adult person aged 18 years or above and persons below the age of 18 years are to be accompanied by their parents. “The entry/exit points would be made functional by the deployment of at least two state police representatives and at least two state health representatives at each entry/exit point for smooth implementation of the system,” the MHA notification said. Manipur has around 400 km of unfenced international border with Myanmar and the Assam Rifles have been guarding the mountainous and difficult border.
Manmohan Singh Abandoned Pre-Medical Course After Losing Interest, Says Daughter's Book
Liverpool punish rivals’ errors with dominant win over Leicester to stretch lead
Bashar al-Assad's government has been accused of carrying out torture, rape, summary executions and other abuses since since Syria's civil war started in 2011. UN investigators have said that accountability must be taken at the highest level after the downfall of the hardline ruler on Sunday. Here is what we know about the extent of the abuses committed: In 2013 a former Syrian army photographer known by the codename "Caesar" fled the country, taking with him some 55,000 graphic images taken between 2011 and 2013. The photos, authenticated by experts, show corpses tortured and starved to death in Syrian prisons. Some people had their eyes gouged out. The photos showed emaciated bodies, people with wounds on the back or stomach, and also a picture of hundreds of corpses in a shed surrounded by plastic bags used for burials. Assad's Syrian government said only that the pictures were "political". But Caesar testified to a US Congress committee and his photographs inspired a 2020 US law which imposed economic sanctions on Syria and judicial proceedings in Europe against Assad's entourage. In Germany and Sweden eight people suspected of crime against humanity were arrested in July in an operation codenamed "Caesar". Germany, the Netherlands and France have since 2022 convicted several top officials from the Syrian intelligence service and militias. UN investigators say they have lists with the names of 4,000 government officials and operatives responsible for abuses. Human Rights Watch (HRW) in 2012 spoke of a "torture archipelago" in which the "use of electricity, burning with car battery acid, sexual assault and humiliation, the pulling of fingernails, and mock execution" were practised in government prisons. The Syrian Observatory for Human Rights said in 2022 more than 100,000 people had died in the prisons since 2011. In 2023, the UN's top court, the International Court of Justice, ordered Syria to stop "inhuman or degrading treatment or punishment". In 2020, seven Syrian refugees filed a complaint in Germany saying that they had been victims of torture and sexual violence, including rape, electric shocks on the genitals, forced nudity or forced abortion between 2011 and 2013. The UN said in 2018 there had been systmatic rape and sexual violence against civilians by soldiers or pro-Assad militias. It said an investigation had found rebels had committed similar crimes, but fewer. On November 25, 2024, the Syrian Human Rights Network (SNHR) said there had been at least 11,553 incidents of sexual violence against women, including girls aged under 18, by the warring parties since March 2011. Some 8,024 could be blamed on the Assad government and the others mainly on the jihadist Islamic State. In 2016 UN investigators said Syrian authorities were responsible for acts which came down to "extermination" and could be compared to "crimes against humanity". It pointed to the Saydnaya prison outside Damascus, which was described in 2017 by Amnesty International as a human slaughter house carrying out a "policy of extermination". The United States said there was a "crematorium" at the prison which was used to dispose of the bodies of thousands of inmates. In 2022 the Syrian Observatory for Human Righs said around 30,000 people had been killed at Saydnaya, some of them after being tortured. In April 2020, the chemical weapons watchdog OPCW accused the Syrian army of chemical weapons attacks in Latamne in northern Syria in 2017. In November 2023 France issued international arrest warrants against Bashar al-Assad, his brother Maher and two generals on suspicion of complicity in the chemical attacks in August 2013 near Damascus, which according to US intelligence left 1,000 dead. Assad's forces have also been accused of using sarin gas on the rebel town of Khan Sheikhun in April 2017, and also of chlorine gas attacks. Assad's government denied using chemical weapons. Israel says it has staged strikes on some chemical weapons sites this week to stop supplies falling into the hands of extremists. acm-lc/jmy/tw