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Lufepirsen is under clinical development by Amber Ophthalmics and currently in Phase II for Persistent Corneal Epithelial Defects. According to GlobalData, Phase II drugs for Persistent Corneal Epithelial Defects does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Lufepirsen overview Lufepirsen is under development for the treatment of persistent corneal epithelial defects which are secondary to trauma and refractory to standard of care. The drug candidate is applied as an ophthalmic gel. The drug candidate binds to connexin 43. CODA-001 is a natural, unmodified antisense oligonucleotide. It was also under development for the treatment of venous leg ulcer, diabetic foot ulcers, skin wounds, and near sightedness after PRK laser eye surgery. Amber Ophthalmics overview Amber Ophthalmics is a clinical-stage biopharmaceutical company that focuses on innovative therapies for rare ophthalmic diseases. It lead product candidate include NEXAGON (lufepirsen ophthalmic gel) treats persistent corneal epithelial defects (PCED). The company’s drug, Nexagon inhibits hemichannel formation, arresting an exaggerated inflammatory cascade. It Restores limbal stem cell function to promote healing. Amber Ophthalmics is headquartered in San Diego, California, the US. For a complete picture of Lufepirsen’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .The last six years have landed Canadian Kurtis Rourke firmly in the U.S. college football limelight. Read this article for free: Already have an account? As we navigate through unprecedented times, our journalists are working harder than ever to bring you the latest local updates to keep you safe and informed. Now, more than ever, we need your support. Starting at $14.99 plus taxes every four weeks you can access your Brandon Sun online and full access to all content as it appears on our website. or call circulation directly at (204) 727-0527. Your pledge helps to ensure we provide the news that matters most to your community! The last six years have landed Canadian Kurtis Rourke firmly in the U.S. college football limelight. Read unlimited articles for free today: Already have an account? The last six years have landed Canadian Kurtis Rourke firmly in the U.S. college football limelight. The 24-year-old Oakville, Ont., native will lead the upstart Indiana Hoosiers (11-1) into South Bend, Ind., to face the Notre Dame Fighting Irish (11-1) on Dec. 20 to open American university football’s expanded playoff bracket. Rourke transferred to Indiana last December to boost his NFL draft stock after five years at Ohio University, where he began as a backup to his older brother, Nathan, then captured the 2022 MAC offensive player of the year award despite suffering a season-ending knee injury before heading to Indiana after the 2023 season. A win over Notre Dame would extend Indiana’s stellar campaign while a loss would mark the end of Rourke’s collegiate career. “Having six years is something not many people can say,” Rourke told Canadian reporters Wednesday. “(It has been) very much a roller-coaster but I’m just grateful. “I’ve had four surgeries in college and only missed a handful of games. That’s the biggest thing I come back to, that I’ve been so lucky to still play and have an opportunity to play (maybe) four more games and hopefully at a professional level.” The six-foot-five, 223-pound Rourke will be eligible for the ’25 NFL draft. Rourke has played a big role in Indiana — traditionally known as a basketball school — emerging as a Big Ten contender in head coach Curt Cignetti’s first season. Rourke completed 202-of-287 passes (70.4 per cent) for 2,827 yards with 27 TDs and just four interceptions in 11 games and last week was named a finalist for the Manning Award, given annually to American college football’s top quarterback. The only blemish on Indiana’s record was a 38-15 loss to Ohio State before 105,751 spectators in Columbus, Ohio, on Nov. 23. Rourke was eight-of-18 passing for 68 yards in that contest and sacked five times. It’s that experience Rourke and the Hoosiers are drawing upon as they prepare to visit Notre Dame Stadium, which has a seating capacity of roughly 77,000 but held 84,000 spectators for a 2018 Garth Brooks concert. “I don’t know if it will be as crazy or as hostile an environment as Ohio State ... but I do expect it to be a pretty good environment,” Rourke said. “We have some plans in place with the silent count if we need at any point to go to ... but ultimately just learning from the experience of Ohio State to handle it individually as well as an offence.” Former CFL player Tino Sunseri is Indiana’s quarterback coach/co-offensive co-ordinator. Sunseri spent three seasons with the Saskatchewan Roughriders (2013-15), winning a Grey Cup as a rookie. Reaching the expanded playoff format in Cignetti’s first season is a huge accomplishment for Indiana. But the school reportedly added 31 players via the transfer portal before the 2024 campaign. When asked how he appealed to incoming players, Cignetti said, “It’s pretty simple, I win. Google me.” Cignetti came to Indiana after posting a 52-9 record over five seasons at James Madison. Rourke said Hoosiers’ players draw inspiration from their brash head coach. “Seeing your head coach on a national stage say what he said, ‘Google me,’ ... that just shows how confident he is in himself and the coaches,” Rourke said. “And that just makes us feel like, ‘Yeah, we’re coming along with you coach.’ “As the season went on we were like, ‘Yeah, we can do this.'” Rourke suffered a right thumb injury that required surgery in Indiana’s 56-7 win over Nebraska on Oct. 19. Fortunately, he missed only one start (31-17 victory over Washington) and returned to throw four TD passes in 47-10 decision over Michigan State on Nov. 2. “My thumb feels 100 per cent now,” Rourke said. “It was hard missing that Washington game ... but I knew the team would have my back.” It’s no surprise Rourke has leaned upon his brother throughout his college tenure. The two are very close and Rourke said he began playing quarterback after watching Nathan do so growing up. Nathan Rourke rejoined the Lions in August after spending time in the NFL with Jacksonville, New England, Atlanta and the New York Giants. “We’ve been able to talk about ball but (also) life,” the junior Rourke said. “Just having someone who’s done it, who’s been through the college experience, been through the NFL experiences and now the CFL to learn from and also bounce questions off him, it’s been quite beneficial to have him in my corner.” Rourke has hired an agent — Octagon’s Casey Muir — and will work out this off-season in Fort Myers, Fla. As of Wednesday, Rourke said he’s not been invited to the NFL combine, which begins Feb. 27 in Indianapolis. “I’d love to get an invite to the combine,” he said. “That was one of my goals, honestly, when I got to college, which seems forever ago. “That would be awesome.” This report by The Canadian Press was first published Dec. 11, 2024. Advertisement Advertisement
National Bank of Canada stock rises Wednesday, still underperforms marketSAN FRANCISCO , Dec. 5, 2024 /PRNewswire/ -- Silicon Valley's seasoned veterans in retail and e-commerce are rallying behind Jingo , a bold leap forward in transforming the online shopping experience. By blending personalization with advanced technology, Jingo is rethinking the way shoppers discover products and how brands connect with their audiences. A Powerhouse Backing Founded by e-commerce veterans, Ujjal Pathak and Rohan Bhanot , who bring years of experience building online shopping platforms, Jingo has secured backing from a powerhouse group of investors and advisors with expertise from leading companies such as Pinterest, Walmart, Minted, eBay, Square, Nike, Klarna, and Intuit. Their collective knowledge in e-commerce, retail, and fintech provides the strategic guidance needed to bring Jingo's vision of a smarter, more equitable shopping platform to life. Solving the Real Problem in E-Commerce Amazon has been shaping online shopping for nearly 30 years, while Walmart has stood as a retail giant for over 60. While these platforms revolutionized e-commerce for past generations, Jingo is built from the ground up to meet the needs of today's digitally native consumers. Designed with Gen Z and Millennials in mind, Jingo delivers a shopping experience that feels intuitive, personal, and deeply connected to modern lifestyles. For customers, the challenge isn't simply finding products—it's making better decisions . Endless choices often lead to decision fatigue and frustration. Jingo tackles this by prioritizing relevance over sheer quantity. Using machine learning, the platform curates and presents personalized assortments early in the shopping journey, showing the most relevant products at the right time. This thoughtful approach fosters confidence and transforms decision-making into an enjoyable process. For brands and sellers, major marketplace platforms often tie visibility to significant advertising spend, creating barriers for smaller players. Jingo flips this model by leveraging advanced machine learning to surface products only to customers with genuine interest. This precision eliminates waste, reduces noise, and ensures that every connection between brands and customers feels meaningful. Empowered by tools like real-time insights, predictive analytics, and curated discovery, brands can optimize inventory, anticipate trends, and connect with their ideal audience without relying on costly campaigns or third-party tools. Jingo is creating a marketplace where both customers and sellers thrive, redefining how value is delivered in online shopping. A Transformative Vision for the Future Jingo's ambitions go far beyond optimizing today's online shopping experience. The platform is building toward a future where commerce is redefined through intelligent systems that seamlessly integrate into users' lives. Imagine a world where shopping evolves from a process you initiate to an experience that happens intuitively. Jingo's end-state vision is to create intelligent systems capable of learning, adapting, and acting on behalf of users , delivering personalized, proactive, and effortless commerce. This approach points to a future where products appear at your doorstep before you even think about shopping, making commerce an invisible yet integral part of daily life. By designing systems that dynamically adapt and provide proactive support, Jingo aims to fundamentally change the way consumers and brands interact, setting a new standard for convenience, personalization, and connection. Flipping the Script for Brands and Sellers Beyond offering better targeting, Jingo is reimagining the commission structure to create a fairer and more seller-focused marketplace. For the first 1,000 brands and sellers who join, Jingo introduces a groundbreaking model: These incentives, coupled with Jingo's advanced tools like predictive analytics and real-time insights, empower sellers to focus on delivering quality products while Jingo ensures they reach the right customers. By reducing the noise-to-signal ratio, brands can build lasting, loyalty-driven relationships in a transparent and equitable ecosystem. Brands and sellers interested in being part of this transformative journey can contact the Jingo team at partner@jingo.app A Bold Vision for E-Commerce With the support of Silicon Valley's leading minds, Jingo is setting a new benchmark for what online shopping can achieve. By addressing decision-making challenges for consumers and creating deeper, more equitable connections for brands, Jingo is leading the next wave of e-commerce innovation. To celebrate its launch, Jingo is running a referral campaign from December 6, 2024 , to February 28, 2025 . Participants can earn credits to shop on the platform once it's live, with prizes of $50,000 for the top referrer, $30,000 for second place, and $10,000 for third. Jingo is more than a platform—it's a movement toward smarter, more personalized, and intuitive commerce. By building systems that anticipate, simplify, and deliver, Jingo is shaping the future of shopping for consumers and sellers alike. Get in Touch For PR inquiries, strategic partnerships, or more information, contact contact@jingo.app View original content to download multimedia: https://www.prnewswire.com/news-releases/redefining-the-future-of-shopping-jingo-gains-silicon-valleys-backing-302324337.html SOURCE Jingo Technologies, Inc.