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How China Became the World’s Largest Gold Consumer and ProducerWILMETTE, Ill., Dec. 05, 2024 (GLOBE NEWSWIRE) -- Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biotechnology company focused on developing innovative treatments for patients with unmet medical needs, today announced the first patient ever dosed with MNPR-101-Lu. This novel therapeutic radiopharmaceutical combines MNPR-101, Monopar’s antibody that selectively targets the urokinase plasminogen activator receptor (uPAR), with the therapeutic radioisotope lutetium-177. uPAR is involved in tumor growth and metastasis, and is found in some of the most aggressive, deadly cancers, including pancreatic, ovarian, triple negative breast, and colorectal cancers. The MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported. This patient, dosed under a compassionate use protocol in the US, has metastatic pancreatic cancer, and prior to dosing, the cancer was imaged using MNPR-101-Zr (a zirconium-89 imaging radioisotope conjugated to MNPR-101) with a PET/CT scanner and showed uPAR expression. “As a result of encouraging biodistribution and dosimetry clinical data we recently reported ( link ) with our radiodiagnostic, MNPR-101-Zr, we have been eagerly looking forward to initiating treatment of patients with MNPR-101-Lu, hopeful it may provide an important therapeutic benefit to a group of cancer patients very much in need,” said Chandler Robinson, MD, Monopar’s Chief Executive Officer. “We are thrilled to have dosed this patient with MNPR-101-Lu, and believe this may be the world’s first dosing of a patient with a uPAR-targeted therapeutic radiopharmaceutical,” said Andrew Cittadine, Monopar’s Chief Operating Officer. Monopar is actively enrolling participants in two Phase 1 clinical studies in Australia, evaluating MNPR-101-Zr for imaging and MNPR-101-Lu for treatment of advanced solid tumors. Further information about the MNPR-101-Lu Phase 1a trial is available at www.ClinicalTrials.gov under study identifier NCT06617169 . Further information about the MNPR-101-Zr Phase 1 imaging and dosimetry clinical trial is available at www.ClinicalTrials.gov under study identifier NCT06337084 . About Monopar Therapeutics Inc. Monopar Therapeutics is a clinical-stage biotechnology company with ALXN-1840 for Wilson disease which has completed a Phase 3 trial, and radiopharma programs including Phase 1-stage MNPR-101-Zr for imaging advanced cancers, and Phase 1a-stage MNPR-101-Lu and late preclinical-stage MNPR-101-Ac225 for the treatment of advanced cancers. For more information, visit: www.monopartx.com . Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of these forward-looking statements include statements concerning: the MNPR-101-Lu intravenous infusion was well-tolerated with no serious adverse reactions reported; that as a result of recently reported encouraging biodistribution and dosimetry clinical data with Monopar’s radiodiagnostic, MNPR-101-Zr, the Company has been eagerly looking forward to initiating treatment and to seeing if the Company can bring an important therapeutic benefit to a group of cancer patients very much in need; and the Company believes this may be the world’s first dosing of a patient with a uPAR-targeted therapeutic radiopharmaceutical. The forward-looking statements involve risks and uncertainties including, but not limited to: that the patient may develop a serious adverse event in the future to MNPR-101-Lu; that radiation dosimetry analytics in the future may not be consistent with the estimated data generated thus far; that Monopar may not find enough patients to successfully enroll its MNPR-101-Lu therapeutic study; that the Phase 1 imaging and dosimetry clinical trial in advanced cancer patients with MNPR-101-Zr may not yield consistently satisfactory results; that future preclinical or clinical data may not be as promising as the data to date; that MNPR-101-Zr and/or MNPR-101-Lu may cause unexpected serious adverse effects or fail to be effective against the cancer tumors in humans; that the trials could result in a clinical hold should there be a Serious Adverse Event; Monopar’s ability to raise sufficient funds in order for the Company to support continued clinical, regulatory and commercial development of its programs and to make contractual future milestone payments, as well as its ability to further raise additional funds in the future to support any future product candidate programs through completion of clinical trials, the approval processes and, if applicable, commercialization; uncertainties related to the regulatory discussions that Monopar intends to initiate related to ALXN-1840 and the outcome thereof; the rate of market acceptance and competitiveness in terms of pricing, efficacy and safety, of any products for which Monopar receives marketing approval, and Monopar’s ability to competitively market any such products as compared to larger pharmaceutical firms; and the significant general risks and uncertainties surrounding the research, development, regulatory approval, and commercialization of imaging agents and therapeutics. Actual results may differ materially from those expressed or implied by such forward-looking statements. Risks are described more fully in Monopar's filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Monopar undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Any forward-looking statements contained in this press release represent Monopar’s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. CONTACT: Monopar Therapeutics Inc. Investor Relations Karthik Radhakrishnan Chief Financial Officer karthik@monopartx.com Follow Monopar on social media for updates: Twitter: @MonoparTx LinkedIn: Monopar TherapeuticsB.C. premier says feds and premiers have right-left strategy to tackle Trump tariffs
The Indiana vs. Notre Dame matchup in the first round of the College Football Playoff is the most expensive ticket on StubHub, but it's Tennessee vs. Ohio State that's selling the fastest. StubHub spokesperson Adam Budelli said Monday that the game being hosted in Columbus, Ohio, on Dec. 21 has sold 34% more tickets than the game in South Bend, Indiana, on Dec. 20. “The expanded college football playoffs are seeing early high demand, especially as we see new teams enter the competition for the first time,” Budelli said. StubHub lists tickets for sale from official event organizers, but most of its offerings are from the resale market. Here's the ticket marketplace's average CFP first-round prices as of Monday evening: 1. Indiana at Notre Dame — $733 2. Clemson at Texas — $518 3. Tennessee at Ohio State — $413 4. SMU at Penn State — $271 Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football Copyright 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.
VICTORIA - British Columbia Premier David Eby says his fellow premiers and the federal government have hatched a game plan to fight U.S. tariffs, with conservative premiers lobbying Republican counterparts, left-leaning provincial leaders courting the Democrats, and Ottawa focusing on president-elect Donald Trump. The premiers and Prime Minister Justin Trudeau talked about using their political diversity and connections to thwart the prospect of Trump’s proposed 25 per cent tariffs on imports from Canada and Mexico, Eby said Thursday in a year-end interview. He said it was discussed that conservative premiers Danielle Smith in Alberta, Doug Ford in Ontario and Nova Scotia’s Tim Houston are well-placed to lobby Republican governors and business leaders. Eby said as a New Democrat he will likely have more in common with Democrat governors and business leaders from the West Coast states. “I can easily have conversations with governors and businesses down the West Coast of the U.S., where we have close relationships and our politics are very similar,” he said. “Premier Smith can have conversations with Republican governors. That would be more challenging for me, and (she) would have more connections potentially with the Trump administration than an NDP administration in B.C. would.” He said a meeting last week between the premiers and Trudeau discussed Canada’s diversity of representation, and how it could bring leverage and advantages in tariff talks. “It’s interesting, there was a lot of talk about what unity means in terms of Canada’s response to the tariffs,” he said. “There’s obviously a diversity of views around the Council of the Federation table of all the premiers. Certainly, mine is not the same as Premier Smith’s or Premier Ford’s or Premier Houston’s, and that diversity of views is actually potentially a significant strength for us as we enter into these discussions.” Eby also said he was prepared to appear on American’s right-leaning Fox News TV network, as did premiers Ford and Smith. “Anything that I can do to support the national effort to protect the families in Canada from the impact of tariffs and also families in the U.S. from those unjustified tariffs,” he said. “Absolutely, if I thought it was helpful.” This report by The Canadian Press was first published Dec. 5, 2024. Note to readers: This is a corrected story. A previous version said Tim Houston’s first name was John.
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DAMASCUS, Syria — Syria's prime minister said Monday that most cabinet ministers were back at work after rebels overthrew President Bashar Assad, but some state workers failed to return to their jobs, and a United Nations official said the country's public sector came "to a complete and abrupt halt." Meanwhile, streams of refugees crossed back into Syria from neighboring countries, hoping for a more peaceful future and looking for relatives who disappeared during Assad's brutal rule. The rebel alliance now in control of much of the country is led by a former senior al-Qaida militant who severed ties with the extremist group years ago and promises representative government and religious tolerance. The rebel command said Monday they would not tell women how to dress. Syrian citizens stand on a government forces tank that was left on a street Monday as they celebrate in Damascus, Syria. "It is strictly forbidden to interfere with women's dress or impose any request related to their clothing or appearance, including requests for modesty," the command said on social media. Nearly two days after rebels entered the capital, some key government services shut down after state workers ignored calls to go back to their jobs, the U.N. official said, causing issues at airports and borders and slowing the flow of humanitarian aid. Rebel leader Ahmad al-Sharaa, who was long known by his nom de guerre Abu Mohammed al-Golani, also met for the first time with Prime Minister Mohammad Ghazi Jalali, who stayed in Syria when Assad fled. Israel said it carried out airstrikes on suspected chemical weapons sites and long-range rockets to keep them from falling into the hands of extremists. Israel also seized a buffer zone inside Syria after Syrian troops withdrew. Syrians wait to cross into Syria from Turkey on Monday at the Oncupinar border gate near the town of Kilis, southern Turkey. In northern Syria, Turkey said allied opposition forces seized the town of Manbij from Kurdish-led forces backed by the United States, a reminder that even after Assad's departure, the country remains split among armed groups that have fought in the past. The Kremlin said Russia granted political asylum to Assad, a decision made by President Vladimir Putin. Kremlin spokesperson Dmitry Peskov declined to comment on Assad's specific whereabouts and said Putin did not plan to meet with him. Damascus was quiet Monday, with life slowly returning to normal, though most shops and public institutions were closed. In public squares, some people still celebrated. Civilian traffic resumed, but there was no public transport. Long lines formed in front of bakeries and other food stores. There was little sign of any security presence, though in some areas small groups of armed men were stationed in the streets. Syrian citizens celebrate Monday during the second day of the takeover of the city by the insurgents in Damascus, Syria. Across swathes of Syria, families are now waiting outside prisons, security offices and courts, hoping for news of loved ones who were imprisoned or who disappeared. Just north of Damascus in the feared Saydnaya military prison, women detainees, some with their children, screamed as rebels broke locks off their cell doors. Amnesty International and other groups say dozens of people were secretly executed every week in Saydnaya, and they estimate that up to 13,000 Syrians were killed between 2011 and 2016. "Don't be afraid," one rebel said as he ushered women from packed cells. "Bashar Assad has fallen!" In southern Turkey, Mustafa Sultan was among hundreds of Syrian refugees waiting at border crossings to head home. He was searching for his older brother, who was imprisoned under Assad. "I haven't seen him for 13 years," he said. "I am going to go see whether he's alive." Jalali, the prime minister, sought to project normalcy since Assad fled. "We are working so that the transitional period is quick and smooth," he told Sky News Arabia TV on Monday, saying the security situation already improved from the day before. Israeli soldiers sit on top of a tank Monday along the so-called Alpha Line that separates the Israeli-annexed Golan Heights from Syria, in the town of Majdal Shams. At the court of Justice in Damascus, which was stormed by the rebels to free detainees, Judge Khitam Haddad, an aide to the justice minister in the outgoing government, said Sunday that judges were ready to resume work quickly. "We want to give everyone their rights," Haddad said outside the courthouse. "We want to build a new Syria and to keep the work, but with new methods." But a U.N. official said some government services were paralyzed as worried state employees stayed home. The public sector "has just come to a complete and abrupt halt," said U.N. Resident and Humanitarian Coordinator for Syria Adam Abdelmoula, noting, for example, that an aid flight carrying urgently needed medical supplies was put on hold after aviation employees abandoned their jobs. "This is a country that has had one government for 53 years and then suddenly all of those who have been demonized by the public media are now in charge in the nation's capital," Abdelmoula told The Associated Press. "I think it will take a couple of days and a lot of assurance on the part of the armed groups for these people to return to work again." People wave Syrian opposition flags at City Hall Square in Copenhagen, Denmark, Sunday, Dec. 8, 2024. (Emil Nicolai Helms/Ritzau Scanpix via AP) People attend a rally celebrating the fall of Syrian President Bashar Assad's government, at central Syntagma square, in Athens, Greece, Sunday, Dec. 8, 2024. (AP Photo/Yorgos Karahalis) People wave Syrian opposition flags at City Hall Square in Copenhagen, Denmark, Sunday, Dec. 8, 2024. (Emil Nicolai Helms/Ritzau Scanpix via AP) People gather to react following the fall of Syrian president Bashar Assad’s government, in Trafalgar Square, in London, Sunday, Dec. 8, 2024. (AP Photo/Alberto Pezzali) People wave Syrian opposition flags at City Hall Square in Copenhagen, Denmark, Sunday, Dec. 8, 2024. (Emil Nicolai Helms/Ritzau Scanpix via AP) People gather to react following the fall of Syrian president Bashar Assad’s government, in Trafalgar Square, in London, Sunday, Dec. 8, 2024. (AP Photo/Alberto Pezzali) People attend a rally celebrating the fall of Syrian President Bashar Assad's government, at central Syntagma square, in Athens, Greece, Sunday, Dec. 8, 2024. (AP Photo/Yorgos Karahalis) Members of the Syrian community in Finland wave a Syrian flag and celebrate in Helsinki, Finland, Dec. 8, 2024. (Roni Rekomaa/Lehtikuva via AP) People attend a rally celebrating the fall of Syrian President Bashar Assad's government, at central Syntagma square, in Athens, Greece, Sunday, Dec. 8, 2024. (AP Photo/Yorgos Karahalis) Syrians wave opposition flags and give out sweets during a spontaneous rally in Wuppertal, Germany, Sunday, Dec. 8, 2024, following the fall of Syrian president Bashar Assad’s government. (Christoph Reichwein/dpa/dpa via AP) Syrians celebrate the fall of the Assad regime in Syria at a demonstration in Stockholm, Sweden, Sunday, Dec. 8, 2024. (Jonas Ekstroemer/TT News Agency via AP) A Syrian man waves a flag during a spontaneous demonstration celebrating the fall of the Assad regime, in Nicosia, Cyprus, Sunday, Dec. 8, 2024. (AP Photo/Petros Karadjias) People gather to celebrate the Syrian government fall at Faith mosque in Istanbul, Turkey, Sunday, Dec. 8, 2024. (AP Photo/Emrah Gurel) Syrians wave Syrian opposition flags at a rally in Wuppertal, Germany, Sunday, Dec. 8, 2024, following the fall of Syrian president Bashar Assad’s government. (Christoph Reichwein/dpa/dpa via AP) People wave Syrian opposition flags at City Hall Square in Copenhagen, Denmark, Sunday, Dec. 8, 2024. (Emil Nicolai Helms/Ritzau Scanpix via AP) Syrians living in France gather on Republique square after the Syrian government fell early today in a stunning end to the 50-year rule of the Assad family, Sunday, Dec. 8, 2024 in Paris. (AP Photo/Aurelien Morissard) People gather to celebrate the Syrian government fall at Faith mosque in Istanbul, Turkey, Sunday, Dec. 8, 2024. (AP Photo/Emrah Gurel) People gather to celebrate the Syrian government fall at Faith mosque in Istanbul, Turkey, Sunday, Dec. 8, 2024. (AP Photo/Emrah Gurel) People gather to celebrate the Syrian government's fall, in Istanbul, Turkey, Sunday, Dec. 8, 2024. (AP Photo/Emrah Gurel) Syrians living in France hug during a rally on Republique square after the Syrian government fell early today in a stunning end to the 50-year rule of the Assad family, Sunday, Dec. 8, 2024 in Paris. (AP Photo/Aurelien Morissard) People gather to react following the fall of Syrian president Bashar Assad’s government, in Trafalgar Square, in London, Sunday, Dec. 8, 2024. (AP Photo/Alberto Pezzali) People gather to celebrate the Syrian government fall at Faith mosque in Istanbul, Turkey, Sunday, Dec. 8, 2024. (AP Photo/Emrah Gurel) People attend a rally celebrating the fall of Syrian President Bashar Assad's government, at central Syntagma square, in Athens, Greece, Sunday, Dec. 8, 2024. (AP Photo/Yorgos Karahalis) A Syrian man waves a flag during a spontaneous demonstration celebrating the fall of the Assad regime in Nicosia, Cyprus, Sunday, Dec. 8, 2024. (AP Photo/Petros Karadjias) Get local news delivered to your inbox!FOXBOROUGH, Mass. (AP) — Drake Maye’s arrival in New England coincided with a wholesale reset for the Patriots franchise following the departure of coach Bill Belichick and quarterback Mac Jones this past offseason. In his eight starts since assuming the reins from veteran Jacoby Brissett, the rookie quarterback has provided encouraging examples of what the Patriots’ revamped front office saw in selecting him third overall in the draft last April. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Get updates and player profiles ahead of Friday's high school games, plus a recap Saturday with stories, photos, video Frequency: Seasonal Twice a week