Immune globulin (human) is under clinical development by and currently in Phase II for Tachycardia (Tachyarrhythmias). According to GlobalData, Phase II drugs for Tachycardia (Tachyarrhythmias) have a 56% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Immune globulin (human) overview Human Immunoglobulin G (also known as human normal immunoglobulin) (Flebogamma DIF/Gamimune N/Gammaked/ Gamunex C/ Flebogamma/ IGIVnex/ GamaSTAN S/D/ Gamunex/ Igamplia/ Plangamma/ Polyglobin/ GamaSTAN, Plitagamma) is an antibody preparation derived from plasma acts as passive immunizing preparation. It is formulated as solution for intramuscular or subcutaneous route of administration. Flebogamma DIF (Double Inactivation and Filtration) and Gamunex is used for replacement therapy in patients with primary immunodeficiency syndromes with impaired antibody production and for hypogammaglobulinemia in various pathological conditions. They also used for the treatment of primary immune thrombocytopenia (ITP), Guillain Barre syndrome and Kawasaki disease. Gamunex-C [Caprylate/Chromatography Purified] is used for the Primary Humoral Immunodeficiency, Idiopathic Thrombocytopenic Purpura (ITP) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Flebogamma DIF is indicated for the treatment of chronic immune thrombocytopenia (ITP) in adults and children aged ≥2 years and primary immunodeficiency (PI) in adults. GamaSTAN S/D is prepared by cold ethanol fractionation from human plasma. GamaSTAN S/D and Igamplia is used for the prophylaxis of rubella, measles, varicella and hepatitis A. Flebogamma DIF and Gammunex injection solution are administered via intravenous route of administration. GamaSTAN S/D and Igamplia are administered by intramuscular route of administration. The drug candidate is also under development for the treatment of Coronavirus disease 2019 (COVID-19), postural tachycardia syndrome, Alzheimer's disease, primary immunedeficiency disease. The drug candidate was also under development for the treatment of cutaneous lupus erythematosus, relapsing remitting multiple sclerosis, epilepsy, myasthenia gravis, stiff-person syndrome and occult choroidal neovascularization. it was also under development for treatment induced neuropathy of diabetes and post-polio syndrome and immune-mediated necrotizing myopathy. Grifols overview develops, produces, and markets plasma-derived medicines and transfusion medicines. The company is focused on research, development, manufacturing and marketing of plasma-derived therapies, hospital pharmacy products and diagnostic technology for clinical use. It produces plasma derived protein therapies for patients suffering from rare, chronic and life-threatening infections. The company’s major products include essential plasma-derived medicines for treating conditions across various therapeutic areas such as neurology, immunology, hepatology, intensive care, pulmonology, hematology, and infectious diseases. provides transfusion medicine, hemostasis and immunoassay solutions for blood banks, clinical laboratories and transfusion centers. The company offers its products to hospitals, pharmacies and healthcare professionals. It offers products in the US, Canada, Europe, and Rest of the world. is headquartered in Barcelona, Spain. For a complete picture of Immune globulin (human)’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Lebanon said Israeli strikes Thursday on the country's east and south killed 52 people, as raids also hit south Beirut and Hezbollah claimed its deepest attack on Israel in over a year. More than 11 months of cross-border fire between Israel and Hezbollah over the Gaza conflict escalated into all-out war in September, with Israel conducting an extensive bombing campaign, primarily targeting Hezbollah strongholds, and sending ground troops into southern Lebanon. "Israeli enemy strikes that targeted the Baalbek district" in east Lebanon's Bekaa Valley left "40 dead and 52 wounded", a health ministry statement said, listing tolls for 10 different locations. Lebanon's official National News Agency (NNA) said a couple and their four children were killed in a strike on a house in the village of Maqneh, while another couple and their young daughter were among 11 people killed in a raid on nearby Nabha. The ministry also reported "seven dead and 24 wounded" in "Israeli enemy strikes" on south Lebanon's Nabatiyeh district, and "five dead and 26 wounded" in strikes elsewhere in south Lebanon. In Israel, first responders said a man was killed after rocket fire from Lebanon hit the Galilee region in the country's north. In Beirut's southern suburbs, the NNA reported at least 12 strikes throughout Thursday, after relative calm while US envoy Amos Hochstein visited earlier this week, seeking to broker an end to the Israel-Hezbollah war. Israeli army spokesman Avichay Adraee on social media platform X issued several rounds of evacuation warnings for Beirut's southern suburbs, as well as areas in and around the southern coastal city of Tyre, but none for east Lebanon. AFPTV footage showed columns of smoke rising from the southern suburbs, usually a densely populated residential district but now largely emptied. Adraee said on X that the Israeli military "targeted a weapons depot, a command headquarters and terrorist infrastructure" belonging to Hezbollah in south Beirut. Amid a series of attack claims, Hezbollah said its fighters targeted "the Hatzor air base" near Israel's southern city of Ashdod, around 150 kilometres (90 miles) from Lebanon's southern border, "with a missile salvo" -- its deepest target in more than a year of hostilities. In 10 separate statements, Iran-backed Hezbollah said its fighters also targeted Israeli troops in and near the south Lebanon town of Khiam, including with artillery, rockets and drones. The NNA said "the enemy army" was "blowing up homes and residential buildings during its incursion into the town". Lebanon's official news agency and Hezbollah have reported fighting and air strikes in the Khiam area ever since Israeli ground troops first entered Lebanon on September 30. Earlier Thursday, United Nations special coordinator for Lebanon Jeanine Hennis-Plasschaert visited Baalbek's UNESCO-listed archaeological area, after the UN's cultural body this week granted more than 30 heritage sites in Lebanon "provisional enhanced protection" amid the war. Lebanon's health ministry said Thursday that at least 3,583 people had been killed in the violence since October 2023. Most of the deaths have been since September this year. The Israeli military said Wednesday that three soldiers were killed in south Lebanon, bringing to 52 the number killed in Lebanon since the start of ground operations. bur-lg/giv3 ways Amazon is making Fire TV more accessible for customers with disabilities
Join our newsletter to get the latest military space news every Tuesday by veteran defense journalist Sandra Erwin. A weekly newsletter that explores the rapidly evolving intersection of space exploration and artificial intelligence. By clicking submit, you agree to share your email address with the site owner to receive the newsletters. You can opt-out at any time. WASHINGTON — The Pentagon’s annual “ Military and Security Developments Involving the People’s Republic of China ” report, released Dec. 18, underscores the accelerating pace of China’s military modernization, with increasing focus on space and artificial intelligence technologies. The report, often referred to as the China Military Power Report, offers insights into Beijing’s expanding capabilities, many of which are aimed at countering U.S. influence in the Indo-Pacific region. This year’s report places new emphasis on China’s use of satellites and AI to bolster its military operations. It describes how Beijing is increasingly leveraging space-based surveillance to track U.S. and allied forces and enhance its precision-strike capabilities. This capability includes integrating satellite data with advanced AI systems to identify vulnerabilities and guide high-precision missile strikes. China’s space capabilities have expanded at a rapid rate, the report notes. In 2010, the country operated a modest fleet of 36 satellites. By 2024, that number has surged to over 1,000, with more than 360 dedicated to intelligence, surveillance, and reconnaissance missions. “The PRC emphasizes the importance of space-based surveillance capabilities in supporting precision strikes and, in 2022, continued to develop its constellation of military reconnaissance satellites that could support monitoring, tracking, and targeting of U.S. and allied forces,” the report states. China has embraced “multi-domain precision warfare,” a strategy that integrates AI, big data, and space technologies to conduct highly coordinated military operations. First articulated by the People’s Liberation Army (PLA) in 2021, this concept mirrors similar strategies pioneered by the Pentagon but now appears to be a cornerstone of China’s military doctrine. The idea is to synthesize vast amounts of intelligence from various domains — land, sea, air, space and cyberspace — to deliver precise, coordinated strikes. In addition to its satellite advancements, China continues to pursue anti-satellite weaponry and reusable space plane technology, the report says. The Pentagon’s assessment suggests that Beijing’s advances are not solely about military confrontation but also reflect ambitions for global technological and strategic leadership.The award, a joint initiative of the European Film Academy and Filmfest Hamburg, is presented by university students from across Europe. debuted in Competition in Cannes earlier this year. Set in a conservative Danube Delta community, it follows a gay teenager’s journey of self-discovery, which clashes with the traditional values of his parents and neighbours. It was selected from five shortlisted films, including Rich Peppiatt’s Dea Kulumbegashvili’s ; Halfdan Ullmann Tondel’s ; and Kurdwin Ayub’s . Since October, the five nominated films, based on the European Film Awards’ Feature and Documentary Film Selections 2024, have been viewed and discussed at 21 universities in 21 countries before each institution selected its favourite film. In early December, one student representative from each university attended a three-day deliberation meeting in Hamburg to decide on the overall winner. The winner was announced at today’s (December 6) Mayor’s Night in Lucerne, the evening before the European Film Awards Ceremony in the city. The EUFA jury said: “The film deconstructs the mechanisms of ostracism, a worldwide problem penetrating societal and institutional structures. With the effective use of resources, the director brilliantly utilised the Romanian landscape to portray the devastating impact of homophobia. Despite decades of activism and political action, queer communities continue to be marginalised by normative society. The film invites the broader European audiences to look beyond their urban horizons and to reflect on the neglected peripheries, where bigotry transcends legislations, and humanity transcends bigotry.”Native American patients are sent to collections for debts the government owes
Middle East latest: Lebanon closes all its land border crossings with Syria except one
TORONTO, Dec. 04, 2024 (GLOBE NEWSWIRE) -- PIMCO Canada Corp. (" PIMCO Canada ”) announced today that at special meetings of the unitholders of PIMCO Tactical Income Fund (TSX: PTI), PIMCO Tactical Income Opportunities Fund (TSX: PTO) and PIMCO Multi-Sector Income Fund (TSX: PIX) (collectively, the " Funds ”) held on December 4, 2024, unitholders of the Funds approved all matters relating to the reorganization of each Fund (the " Mergers ”), each currently structured as a trust, whereby holders of units of the Funds will become holders of the same class of units of PIMCO Monthly Enhanced Income Fund (TSX: PMEI), a new non-redeemable investment fund structured as a trust managed by PIMCO Canada, all as more particularly described in the Management Information Circular of the Funds dated October 18, 2024. The necessary regulatory and independent review committee approvals have also been received. Accordingly, PIMCO Canada expects to proceed with the Mergers on December 20, 2024. The Funds will continue to trade as normal up until the Mergers. Units of each Fund are anticipated to be delisted from the Toronto Stock Exchange at market close on December 20, 2024. Subject to satisfying the listing requirements of the Toronto Stock Exchange, units of PIMCO Monthly Enhanced Income Fund are anticipated to commence trading on Monday, December 23, 2024 following the Merger. A copy of the final non-offering prospectus for PIMCO Monthly Enhanced Income Fund will be filed by the Manager and available at the Manager's website at www.pimco.ca or at www.sedarplus.com. About PIMCO PIMCO is one of the world's premier fixed income investment managers. With its launch in 1971 in Newport Beach, California, PIMCO introduced investors to a total return approach to fixed income investing. In the 50+ years since, the firm continued to bring innovation and expertise to our partnership with clients seeking the best investment solutions. Today PIMCO has offices across the globe and 2,500+ professionals united by a single purpose: creating opportunities for investors in every environment. PIMCO is owned by Allianz SE, a leading global diversified financial services provider. Forward-Looking Statements Certain statements included in this news release constitute forward-looking statements, including, but not limited to, those identified by the expressions "expect”, "anticipate”, "will” and similar expressions to the extent they relate to the Funds. The forward-looking statements are not historical facts but reflect the Fund's, PIMCO Canada and/or PIMCO's current expectations regarding future results or events. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results or events to differ materially from current expectations, including, but not limited to, market factors. Although the Fund, PIMCO Canada and/or PIMCO believes that the assumptions inherent in the forward-looking statements are reasonable, forward-looking statements are not guarantees of future performance and, accordingly, readers are cautioned not to place undue reliance on such statements due to the inherent uncertainty therein. The Fund, PIMCO Canada and/or PIMCO undertakes no obligation to update publicly or otherwise revise any forward-looking statement or information whether as a result of new information, future events or other factors which affect this information, except as required by law. You will usually pay brokerage fees to your dealer if you purchase or sell units of the investment funds on Toronto Stock Exchange. If the units are purchased or sold on the TSX, investors may pay more than the current net asset value when buying units of the investment fund and may receive less than the current net asset value when selling them. There are ongoing fees and expenses associated with owning units of an investment fund. An investment fund must prepare disclosure documents that contain key information about the fund. You can find more detailed information about the fund in these documents. Investment funds are not guaranteed, their values change frequently and past performance may not be repeated. A word about risk: All investments contain risk and may lose value. Investing in the bond market is subject to risks, including market, interest rate, issuer, credit, inflation risk, and liquidity risk. The value of most bonds and bond strategies are impacted by changes in interest rates. Bonds and bond strategies with longer durations tend to be more sensitive and volatile than those with shorter durations; bond prices generally fall as interest rates rise, and low interest rate environments increase this risk. Reductions in bond counterparty capacity may contribute to decreased market liquidity and increased price volatility. Bond investments may be worth more or less than the original cost when redeemed. PIMCO as a general matter provides services to qualified institutions, financial intermediaries and institutional investors. Individual investors should contact their own financial professional to determine the most appropriate investment options for their financial situation. This material has been distributed for informational purposes only and should not be considered as investment advice or a recommendation of any particular security, strategy or investment product. No part of this material may be reproduced in any form, or referred to in any other publication, without express written permission. PIMCO is a trademark of Allianz Asset Management of America LLC in the United States and throughout the world. ©2024, PIMCO The products and services provided by PIMCO Canada Corp. may only be available in certain provinces or territories of Canada and only through dealers authorized for that purpose. PIMCO Canada has retained PIMCO LLC as sub-adviser. PIMCO Canada will remain responsible for any loss that arises out of the failure of its sub-adviser. PIMCO Canada Corp. 199 Bay Street, Suite 2050, Commerce Court Station, P.O. Box 363, Toronto, ON, M5L 1G2 is a company of PIMCO, 416-368-3350 Contact: Agnes Crane PIMCO - Media Relations Ph. 212-597-1054 Email: [email protected]MacKenzie Scott gives rare third gift to medical debt relief group
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Robo price-fixing: Why the Justice Department is suing a software company to stop landlords colluding on rents − a practice that costs renters billionsCHICAGO -- The Seattle Seahawks will be without Kenneth Walker III for their playoff push after placing their leading rusher on injured reserve Thursday. Walker had already been ruled out for the Thursday night game against the Chicago Bears because of an ankle injury he suffered Sunday. He went down in the fourth quarter of Seattle's loss to the Minnesota Vikings , did not return to the game and was listed as a nonparticipant all three days this week. To take Walker's place on the 53-man roster, the Seahawks signed rookie George Holani off their practice squad. Holani will serve as their third running back behind Zach Charbonnet and Kenny McIntosh . Seattle also elevated cornerback Artie Burns for the Bears game. Editor's Picks 'Feeling stronger, feeling faster': Seahawks WR Jaxon Smith-Njigba having breakout sophomore season 3h Brady Henderson Week 17 NFL Power Rankings: 1-32 poll, plus every team's rookie of the year 2d NFL Nation Walker's third NFL season has been marred by injuries. The 2022 second-round pick missed two games in September after hurting his oblique in the opener and two more in December with a calf injury. Going on IR will sideline him for a minimum of four games, meaning his season is over unless the Seahawks make a deep playoff run. In 11 games, Walker leads the Seahawks with 573 rushing yards and 153 carries, scoring seven rushing touchdowns. Charbonnet, who will again take over as the team's No. 1 back with Walker out, has 453 rushing yards on 106 carries and a team-high eight rushing touchdowns in 15 games. With Walker in and out of the lineup this season, the Seahawks rank 30th in rushing yards per game (91.9) and 23rd in yards per carry (4.1). A loss to Chicago coupled with a Los Angeles Rams win over the Arizona Cardinals on Saturday would eliminate Seattle (8-7) from playoff contention.
Mobile homes are a viable form of low-income housing. So, why isn’t it being factored in to solve the housing crisis?