EAGAN, Minn. (AP) — Minnesota Vikings linebacker Ivan Pace Jr. has been placed on injured reserve after hurting his hamstring Sunday in a 30-27 overtime victory over the Chicago Bears. The move announced Tuesday means that Pace must miss at least the Vikings next four games. The Vikings also activated outside linebacker Gabriel Murphy from injured reserve and signed linebacker Jamin Davis off the Green Bay Packers practice squad. Pace, 23, had started each of the Vikings nine games this season. The 2023 undrafted free agent from Cincinnati had 56 tackles — including six for loss — and three sacks. Murphy, 24, signed with the Vikings as an undrafted free agent this spring. He was placed on injured reserve Aug. 27. Davis had joined the Packers practice squad Oct. 29 after getting released by the Washington Commanders a week earlier. Washington selected him out of Kentucky with the 19th overall pick in the 2021 draft. The 25-year-old Davis has 282 tackles, seven sacks, one interception, two forced fumble recoveries and two forced fumbles in his NFL career. He led the Commanders with a career-high 104 tackles in 2022. The Vikings (9-2) host the Arizona Cardinals (6-5) on Sunday. AP NFL: https://apnews.com/hub/NFL
‘Some appalling shots’: Carnage for England as Kiwis run rampant in blistering first hourRussia has a stock of powerful new missiles "ready to be used", President Vladimir Putin has said, a day after his country fired a new ballistic missile at the Ukrainian city of Dnipro. In an unscheduled TV address, the Russian leader said the Oreshnik missile could not be intercepted and promised to carry out more tests, including in "combat conditions". Russia's use of the Oreshnik capped a week of escalation in the war that also saw Ukraine fire US and British missiles into Russia for the first time. Ukrainian President Volodymyr Zelensky called for world leaders to give a "serious response" so that Putin "feels the real consequences of his actions". His country was asking Western partners for updated air defence systems, he added. According to news agency Interfax-Ukraine, Kyiv is seeking to obtain the US Terminal High Altitude Area Defense (THAAD), or to upgrade its Patriot anti-ballistic missile defence systems. In Friday's address Putin said the Oreshnik hypersonic missiles flew at 10 times the speed of sound and ordered them to be put into production. He had earlier said that use of the missile was a response to Ukraine's use of Storm Shadow and Atacms missiles. Thursday's strike on Dnipro was described as unusual by eyewitnesses and triggered explosions which went on for three hours. The attack included a strike by a missile so powerful that in the aftermath Ukrainian officials said it resembled an intercontinental ballistic missile (ICBM). Justin Crump, CEO and founder of the risk advisory company Sibylline, told the BBC that Moscow likely used the strike as a warning, noting that the missile - which is faster and more advanced that others in its arsenal - has the capacity to seriously challenge Ukraine's air defences. This week's escalation has also prompted several warnings from other world leaders about the direction of the war between Russia and Ukraine. Polish Prime Minister Donald Tusk said the war was entering a decisive stage - with a real risk of global conflict. Hungarian Prime Minister Viktor Orban meanwhile said the West should take Vladimir Putin's warnings "at face value" because Russia "bases its policies primarily on military power". And North Korea's leader Kim Jong Un warned "never before" had the threat of a nuclear war been greater and accused the US of having an "aggressive and hostile" policy towards Pyongyang. North Korea has sent thousands of troops to fight on Russia's side and Ukrainian forces have reported clashes with them in Russia's Kursk region, where Ukrainian troops are occupying some territory. US President Biden has said he gave Ukraine permission to use longer-range Atacms missiles against targets inside Russia as a response to Moscow's use of North Korean troops. Both Russia and Ukraine are trying to secure a battlefield advantage before Donald Trump becomes US president in January. Trump has vowed to end the war within hours but has not provided details as to how. In his nightly address, Zelensky also criticised China for its response to Moscow's new missile after China's foreign ministry said all parties should "remain calm and exercise restraint". "From Russia, this is a mockery of the position of states such as China, states of the Global South, some leaders who call for restraint every time," he said. He also criticised the Ukrainian parliament for postponing a session on Friday over security concerns following the attack on Dnipro. In a post on Telegram, he said unless an air raid signal sounded everyone should work as normal - and not take Russian threats as "permission to have a day off". "The siren sounds - we go to shelter. When there is no siren - we work and serve. There is no other way in war," he said.
(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024NoneGeorgia's ombudsman accuses police of torturing pro-EU protesters
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