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2025-01-13
Lufepirsen is under clinical development by Amber Ophthalmics and currently in Phase II for Persistent Corneal Epithelial Defects. According to GlobalData, Phase II drugs for Persistent Corneal Epithelial Defects does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Lufepirsen overview Lufepirsen is under development for the treatment of persistent corneal epithelial defects which are secondary to trauma and refractory to standard of care. The drug candidate is applied as an ophthalmic gel. The drug candidate binds to connexin 43. CODA-001 is a natural, unmodified antisense oligonucleotide. It was also under development for the treatment of venous leg ulcer, diabetic foot ulcers, skin wounds, and near sightedness after PRK laser eye surgery. Amber Ophthalmics overview Amber Ophthalmics is a clinical-stage biopharmaceutical company that focuses on innovative therapies for rare ophthalmic diseases. It lead product candidate include NEXAGON (lufepirsen ophthalmic gel) treats persistent corneal epithelial defects (PCED). The company’s drug, Nexagon inhibits hemichannel formation, arresting an exaggerated inflammatory cascade. It Restores limbal stem cell function to promote healing. Amber Ophthalmics is headquartered in San Diego, California, the US. For a complete picture of Lufepirsen’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Narin An leads with a 64 in the wind as Nelly Korda struggles in LPGA finaleStocks Are Rallying, but Big Tech Is Still a Dragz n r

Larson Financial Group LLC Buys 4,285 Shares of BlackRock MuniYield Quality Fund III, Inc. (NYSE:MYI)

Algert Global LLC Acquires Shares of 78,900 Amplitude, Inc. (NASDAQ:AMPL)WASHINGTON — The leaders of the FBI and the Department of Homeland Security declined to testify publicly at a scheduled Senate committee hearing Thursday on global threats to national security, a break from standard protocol of open testimony before the panel. “Their choice to not provide public testimony about their departments’ efforts to address wide-ranging national security threats robs the American people of critical information and the opportunity for public accountability of what the federal government is doing to keep Americans safe,” Sen. Gary Peters, chairman of the Senate Homeland Security and Governmental Affairs committee, said in a statement. The Michigan Democrat said it was the first time in more than 15 years that an FBI director and Homeland Security secretary had together refused to offer public testimony at the annual committee hearing focused on threats to the homeland, calling it a “shocking departure” from tradition. A separate hearing scheduled for Wednesday before the House Homeland Security committee also was postponed. The hearings were to have taken place at a time of significant political transition as Trump is interviewing candidates to replace FBI Director Christopher Wray and has named South Dakota Gov. Kristi Noem to succeed Homeland Security Secretary Alejandro Majorkas. The threats hearings are an opportunity for members of Congress to hear from these agencies about what they see as key threats facing the nation ranging from weapons of mass destruction to natural disasters. It’s usually the head of the agency that appears although not always. During the first Trump administration when there was frequent turnover at the Department of Homeland Security, DHS Under Secretary David Glawe appeared 2019. Acting Deputy Secretary Kenneth Cuccinelli appeared in 2020 during the pandemic when some members of the panel appeared virtually. The Senate committee usually starts scheduling its annual hearing months in advance, and previous hearings have always included a public component. The committee was informed Monday that Mayorkas and Wray would not be appearing. In a statement Thursday, the FBI said it had “repeatedly demonstrated our commitment to responding to Congressional oversight and being transparent with the American people” and remained “committed to sharing information about the continuously evolving threat environment facing our nation. “FBI leaders have testified extensively in public settings about the current threat environment and believe the Committee would benefit most from further substantive discussions and additional information that can only be provided in a classified setting,” the statement said. The Department of Homeland Security said in a statement that they and the FBI offered to speak to the committee in a classified setting and emphasized the amount of unclassified information they’ve already shared publicly. “DHS and the FBI already have shared with the Committee and other Committees, and with the American public, extensive unclassified information about the current threat environment, including the recently published Homeland Threat Assessment. DHS takes seriously its obligation to respond to Congressional requests for testimony,” the department said. The agency also noted that Mayorkas has testified in Congress 30 times during the nearly four years he’s held his job.Pooches in pullovers strut their stuff at London's canine Christmas sweater parade

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