Person accused of accosting Rep. Nancy Mace at Capitol pleads not guilty to assault charge
Published 4:10 pm Tuesday, November 26, 2024 By Submitted Anna Stene of Lake MIlls wrestles an opponent from Nevada during a quadrangular meet Monday in Lake Mills. Photo courtesy Lory Groe Mikayla Aschenbrenner of Lake Mills takes on an opponent from Eagle Grove Monday night at home. Photo courtesy Lory Groe The team won 66-12 against Eagle Grove, 52-24 against Nevada and 66-12 against Webster City. Photo courtesy Lory Groe
Chinese robot masters massage techniques, pinches, vibrates with human-like handsNew Delhi, Dec 30 (IANS): Samajwadi Party (SP) legislator Rais Shaikh has written to Maharashtra Chief Minister Devendra Fadnavis urging the state government to hold the long-overdue elections to local bodies, including the Brihanmumbai Municipal Corporation (BMC), before March 7, 2025. The letter, also addressed to Deputy Chief Minister and Urban Development Minister Eknath Shinde, highlights the prolonged delay in restoring democratic governance to local bodies across Maharashtra. In his letter, Shaikh stressed that the BMC, the largest local government body in Asia, has been functioning without elected representatives since March 7, 2022, when its previous term ended. The current administrator is set to complete three years in office by March 7, 2025. "It is not a matter of pride for Indian democracy that the financial capital of the country has been run for so long without people's representatives," he stated. Shaikh also pointed out that elections to 29 municipal corporations, 228 municipal councils, 29 Nagar Panchayats, 26 Zilla Parishads, and 289 Panchayat Samitis in the state remain pending. He demanded that these elections, including those for the BMC, be conducted without further delay to uphold democratic principles. Following the state Assembly elections, political parties are preparing for local body elections, including those for the BMC, which is the wealthiest civic body in the country. On February 2, it presented a Rs 59,954.75 crore budget for the year 2024-25. However, sources indicate that these elections are unlikely to take place before April due to ongoing Supreme Court cases concerning the number of wards, the number of councillors per ward, and the process for the wards' formation. Elections for all 29 municipal corporations in the state, as well as approximately 280 nagar parishads and nagar panchayats, are still pending. These local bodies are currently being managed by administrators. In some cases, elections for municipal corporations have been delayed for 2 to 3 years. Notably, the BMC has been under the administration of an appointed official for two and a half years, following the expiration of its term in March 2022.Injured?: Shah Rukh Khan bumps his head on jetty ceiling while shielding his face in oversized hoodie while holding his cute dog
New Delhi, December 30: Leading music streaming platform Spotify found itself in a controversy when some users saw sexually-explicit material in search results on the platform. According to a report in The Verge on Monday, a Reddit user posted a screenshot of a Spotify search that had “a pornographic video tucked into suggested results for the rapper M.I.A”. A Spotify spokesperson told The Verge that such content "has been removed due to violation of its policies". According to the music streaming platform’s content moderation policies, it removes content that contains sexually explicit material. Samsung Galaxy S24 Ultra 5G Price Drops Ahead of Launch of Samsung Galaxy S25 Ultra 5G in January 2025; Check Discounts, Offers and Other Benefits Here. Recent posts on Reddit have shown examples of “unexpected explicit video in search results” on Spotify and “even erotic audio tracks being suggested in one user’s Discovery Weekly algorithmic playlist”. A Vice story in 2022 had claimed that there was “a surprising amount of people who’ve tried to upload hardcore sex images on Spotify”. According to reports, the app has a setting to block explicit content playback in users’ profiles, but even with it turned on, these searches evade that filter. Spotify’s terms of use forbid ”pornography or visual depictions of genitalia or nudity presented for the purpose of sexual gratification.” The music streaming platform was launched in 2008. Today, more listeners than ever can discover, manage and enjoy over 100 million tracks, 6 million podcasts titles, and 350,000 audiobooks a la carte on Spotify. “We are the world’s most popular audio streaming subscription service with more than 640 million users, including 252 million subscribers in more than 180 markets,” according to the company. Google CEO Sundar Pichai Prepares Employees for 2025, Tells Them Company Will Focus on ‘Gemini’ AI Model Amid Regulatory Challenges, Fierce Competition: Report. Spotify’s global premium subscriber base grew to just over 252 million paying users for the third quarter of 2024 (ended September 30). The total global monthly active users (MAUs) grew 11 per cent on-year to 640 million in Q3 2024. (The above story first appeared on LatestLY on Dec 30, 2024 10:42 AM IST. For more news and updates on politics, world, sports, entertainment and lifestyle, log on to our website latestly.com ).Cricket News Live: Crickit's T20 World Cup 2024 coverage gets more comprehensive with an in-depth stats data pool, also featuring player profiles, points table standings, top performers, and historical data of the tournament. Moreover, experience the thrill of the T20 World Cup 2024 with our live commentary and match coverage. Join us as we bring you ball-by-ball updates, expert analysis, engaging commentary, photo galleries, and video stories. Follow us for all the latest T20 World Cup News, T20 World Cup News Live, T20 World Cup Cricket News Live, articles, player stats, commentary, and other exciting content related to the T20 World Cup. Stay informed with up-to-the-minute news and updates on cricket, as we bring to you the latest developments. From injury updates and match previews to post-match analysis and records made, we've got you covered with all the information you need to stay in the loop. Dive deeper into the action with our insightful articles and analysis, where our team breaks down key matches, players' performances and team strategies for all that's cricket. Also, gain insights into team dynamics and emerging trends that could impact the outcome of the tournament. Track the pulse of cricket with our comprehensive stats coverage, featuring in-depth statistics, player profiles, points table standings, top performers and historical data. Whether you are a cricket enthusiast or a stats nerd, our extensive database provides you with all the numbers that you need. Moreover, experience the thrill of matches with our live commentary and match coverage. Join us as we bring you ball-by-ball updates, expert analysis and engaging commentary, photo galleries and video stories- ensuring you don't miss a single moment of the action-packed cricketing extravaganza. So, what are you waiting for? Follow us for all the latest news, updates, articles, Player Stats, commentary, and other exciting content related to cricket. ...Read More Cricket Live Updates Today : ‘Jasprit Bumrah is this genie, you make a wish and you get it’: Manjrekar spellbound by IND pacer's incredible skills Cricket Live Updates Today : 'Captain Cry Baby': Australian media tears into Rohit Sharma after 'Clown Kohli' controversy over blow-up at Jaiswal Cricket Live Updates Today : 'Don't know where Rohit Sharma is mentally. No clue': Sourav Ganguly's concerning verdict on India captain's 'future'Sir Keir Starmer has led a host of tributes to former US president Jimmy Carter, saying he “redefined the post-presidency with a remarkable commitment to social justice and human rights at home and abroad”. The Prime Minister said Mr Carter, who died aged 100, will be remembered for the Camp David Accords between Israel and Egypt, as well as his “decades of selfless public service”. He added that it was the Democrat’s “lifelong dedication to peace” that led to him receiving the Nobel Peace prize in 2002. Very sorry to hear of President Carter’s passing. I pay tribute to his decades of selfless public service. My thoughts are with his family and friends at this time. pic.twitter.com/IaKmZcteb1 — Keir Starmer (@Keir_Starmer) December 29, 2024 Sir Keir was joined in paying tribute to the 39th president by other leaders including the King, current President Joe Biden, Lib Dem leader Sir Ed Davey and former PM Tony Blair. The King remembered former US president Jimmy Carter’s 1977 visit to the UK with “great fondness” and praised his “dedication and humility”. In a message to Mr Biden and the American people, Charles said: “It was with great sadness that I learned of the death of President Carter. “He was a committed public servant, and devoted his life to promoting peace and human rights. “His dedication and humility served as an inspiration to many, and I remember with great fondness his visit to the United Kingdom in 1977. “My thoughts and prayers are with President Carter’s family and the American people at this time.” Mr Biden said that Mr Carter was an “extraordinary leader, statesman and humanitarian”. He said his fellow Democrat was a “dear friend”, as he announced that he will order a state funeral to be held for him in Washington DC. “Today, America and the world lost an extraordinary leader, statesman and humanitarian,” he said. “Over six decades, we had the honour of calling Jimmy Carter a dear friend. But, what’s extraordinary about Jimmy Carter though is that millions of people throughout America and the world who never met him thought of him as a dear friend as well. “With his compassion and moral clarity, he worked to eradicate disease, forge peace, advance civil rights and human rights, promote free and fair elections, house the homeless, and always advocate for the least among us. He saved, lifted and changed the lives of people all across the globe. “He was a man of great character and courage, hope and optimism.” Lib Dem leader Sir Ed Davey said Mr Carter “will be remembered for generations”. “Jimmy Carter was an inspiration,” Mr Davey wrote on X. “He led a truly remarkable life dedicated to public service with a genuine care for people. “My thoughts are with his family, friends and all those who loved him. He will be remembered for generations.” Mr Blair said: “Jimmy Carter’s life was a testament to public service; from his time in office, and the Camp David Accords, to his remarkable commitment to the cause of people and peace round the world over the past 40 years,” he said. “I always had the greatest respect for him, his spirit and his dedication. He fundamentally cared and consistently toiled to help those in need.”
ROME (AP) — Robert Lewandowski joined Cristiano Ronaldo and Lionel Messi as the only players in Champions League history with 100 or more goals. But Erling Haaland is on a faster pace than anyone by boosting his total to 46 goals at age 24 on Tuesday. Still, Haaland's brace wasn't enough for Manchester City in a 3-3 draw with Feyenoord that extended the Premier League champion's winless streak to six matches. Lewandowski’s early penalty kick started Barcelona off to a 3-0 win over previously unbeaten Brest to move into second place in the new single-league format. The Poland striker added goal No. 101 in second-half stoppage time. Ronaldo leads the all-time scoring list with 140 goals and Messi is next with 129. But neither Ronaldo nor Messi play in the Champions League anymore following moves to Saudi Arabia and the United States, respectively. The 36-year-old Lewandowski required 125 matches to reach the century mark, two more than Messi (123) and 12 fewer than Ronaldo (137). Barcelona also got a second-half score from Dani Olmo. The top eight finishers in the standings advance directly to the round of 16 in March. Teams ranked ninth to 24th go into a knockout playoffs round in February, while the bottom 12 teams are eliminated. Haaland converted a first-half penalty to eclipse Messi as the youngest player to reach 45 goals then scored City's third after the break to raise his total to 46 goals in 44 games. Ilkay Gundogan had City's second. But then Feyenoord struck back with goals from Anis Hadj Moussa, Santiago Gimenez and David Hancko. Inter Milan beat Leipzig 1-0 with an own goal to move atop the standings with 13 points, one more than Barcelona and Liverpool, which faces Real Madrid on Wednesday. The Serie A champion is the only club that hasn't conceded a goal. Bayern Munich beat Paris Saint-Germain 1-0 — the same score from the 2020 final between the two teams. PSG ended with 10 men and remained in the elimination zone. The French powerhouse has struggled in Europe after Kylian Mbappe’s move to Real Madrid. Atalanta moved within two points of the lead with a 6-1 win at Young Boys. Also, Arsenal won 5-1 at Sporting Lisbon; and Bayer Leverkusen routed Salzburg 5-0. AC Milan followed up its win at Real Madrid with a 3-2 victory at last-place Slovan Bratislava in an early match. Christian Pulisic put the seven-time champion ahead midway through the first half by finishing off a counterattack. Then Rafael Leao restored the Rossoneri’s advantage after Tigran Barseghyan had equalized for Bratislava and Tammy Abraham quickly added another. Nino Marcelli scored with a long-range strike in the 88th for Bratislava, which ended with 10 men. Bratislava has lost all five of its matches. Argentina World Cup winner Julian Alvarez scored twice and Atletico Madrid routed Sparta Prague 6-0 in the other early game. Alvarez scored with a free kick 15 minutes in and Marcos Llorente added a long-range strike before the break. Alvarez finished off a counterattack early in the second half after being set up by substitute Antoine Griezmann, who then marked his 100th Champions League game by getting on the scoresheet himself. Angel Correa added a late brace for Atletico, which earned its biggest away win in Europe. Atletico beat Paris Saint-Germain in the previous round and extended its winning streak across all competitions to six matches. AP soccer: https://apnews.com/hub/soccerX-ray Inspection Systems Market Size, Latest Growth, Forecast By 2024 - 2032 11-26-2024 08:01 PM CET | Business, Economy, Finances, Banking & Insurance Press release from: Prudent Markets X-ray Inspection Systems Market X-ray Inspection Systems Market Trends In 2024: The X-ray Inspection Systems Market 2024 report provides a comprehensive analysis of Types (Digital Radiography (DR), Computed Tomography (CT), X-ray film), Application (General industry, Automotive industry, Packaging), Analysis of Industry Trends, Growth, and Opportunities, R&D landscape, Data security and privacy concerns Risk Analysis, Pipeline Products, Assumptions, Research Timelines, Secondary Research and Primary Research, Key Insights from Industry Experts, Regional Outlook and Forecast, 2024-2032. Major Players of X-ray Inspection Systems Market are: YXLON International, Nikon Metrology, GE Measurement & Control, Anritsu Industrial Solutions, North Star Imaging, Ishida, Mettler-Toledo International, VJ Technologies, Bosello High Technology, Nordson, Sesotec GmbH, Aolong Group, Loma, DanDong Huari, Shimadzu, Thermo Fisher Scientific, Dylog, Meyer, Minebea Intec, Mesna Get PDF Sample Report Now! @ https://www.prudentmarkets.com/sample-request/33364/ Segmentation of X-ray Inspection Systems Market- By Type Digital Radiography (DR), Computed Tomography (CT), X-ray film By Application General industry, Automotive industry, Packaging Strategic Points Covered in Table of Content of Global X-ray Inspection Systems Market: Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the X-ray Inspection Systems market Chapter 2: Exclusive Summary - the basic information of the X-ray Inspection Systems Market. Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges & Opportunities of the X-ray Inspection Systems Chapter 4: Presenting the X-ray Inspection Systems Market Factor Analysis, Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis. Chapter 5: Displaying the by Type, End User and Region/Country Chapter 6: Evaluating the leading manufacturers of the X-ray Inspection Systems market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile Chapter 7: To evaluate the market by segments, by countries and by Manufacturers/Company with revenue share and sales by key countries in these various regions Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source To Understand How Covid-19 Impact Is Covered in This Report @ https://www.prudentmarkets.com/sample-request/33364/ Key Benefits of the Report: This study presents the analytical depiction of the X-ray Inspection Systems Industry along with the current trends and future estimations to determine the imminent investment pockets. The report presents information related to key drivers, restraints, and opportunities along with detailed analysis of the X-ray Inspection Systems Market share. The current market is quantitatively analyzed from to highlight the Global Gardening Pots Market growth scenario. Porter's five forces analysis illustrates the potency of buyers & suppliers in the market. The report provides a detailed X-ray Inspection Systems Market analysis based on competitive intensity and how the competition will take shape in coming years. Prudent Markets provides attractive discounts that fit your needs. Customization of the reports as per your requirement is also offered. Get in touch with our sales team, who will guarantee you a report that suits your needs. Speak To Our Analyst For A Discussion On The Above Findings, And Ask For A Discount On The Report @ https://www.prudentmarkets.com/discount-request/33364/ The report covers the competitive analysis of the market. As the demand is driven by a buyer's paying capacity and the rate of item development, the report shows the important regions that will direct growth. This section exclusively shares insight into the budget reports of big-league members of the market helping key players and new entrants understand the potential of investments in the Global X-ray Inspection Systems Market. It can be better employed by both traditional and new players in the industry for complete know-how of the market. Why should you purchase this report? -Prudent Markets provides the vital historical and analysis data of global X-ray Inspection Systems market. -The report provides the entire assessment of the future market and altering market scenario or behavior. -All the business decision could be backed through the several strategic business methodologies offered in the report. -An extra edge in the competitive market could be obtained from this elaborative research report -The report offers all the competitive landscape, growth drivers, applications, market dynamics, and other necessary details as well. For In-Depth Competitive Analysis - Purchase this Report now at a Complete Table of Contents (Single User License) @ https://www.prudentmarkets.com/checkout/?id=33364&license_type=su Free Customization on the basis of client requirements on Immediate purchase: 1- Free country-level breakdown of any 5 countries of your interest. 2- Competitive breakdown of segment revenue by market players. Customization of the Report: This report can be customized to meet the client's requirements. Please connect with our sales team (sales@prudentmarkets.com), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +91 83560 50278 || USA/Canada(Toll Free): 1800-601-6071 to share your research requirements. Get ready to Recognize the pros and cons of the regulatory framework, local reforms, and its effect on the Industry. Understand how the Leaders in Intelligent Network are keeping themselves one stage forward with our most up-to-date survey analysis. In conclusion, the X-ray Inspection Systems Market report is a genuine source for accessing the research data which is projected to exponentially grow your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rates, and figures. SWOT analysis and PESTLE analysis is also incorporated in the report. Contact Us: Allan Carter Andheri, Maharashtra, 400102 USA/Canada(Toll Free): 1800-601-6071 Direct Line: +91 83560 50278 Mail: sales@prudentmarkets.com Web: www.prudentmarkets.com About Us: We are leaders in market analytics, business research, and consulting services for Fortune 500 companies, start-ups, financial & government institutions. Since we understand the criticality of data and insights, we have associated with the top publishers and research firms all specialized in specific domains, ensuring you will receive the most reliable and up to date research data available. To be at our client's disposal whenever they need help on market research and consulting services. We also aim to be their business partners when it comes to making critical business decisions around new market entry, M&A, competitive Intelligence and strategy. This release was published on openPR.LANSING, Mich. -- Michigan's elections board voted unanimously Friday to certify the results of the 2024 election , a stark difference from 2020 when Republican allies of Donald Trump sought to delay certification in an effort to cast doubt on the election. The Michigan Board of State Canvassers voted 4-0 to certify the election results. The panel consisting of two Democratic and two Republican members also voted to thank and commend the state Bureau of Elections and election administrators throughout the state for a well-run election. “Just a note of thanks, publicly, to the team at Bureau of Elections and to all the folks downstate for a fabulous election,” Republican member Richard Houskamp said before the board voted to certify the results. Four years ago, Trump and his supporters pressured election officials in the state’s largest county and on the state board to not certify the results of the 2020 election as part of his targeted efforts to overturn the election. Trump personally pressured two Republican officials on the Wayne County Board of Canvassers that year to oppose certification. The county is home to Detroit, a stronghold of Democratic voters in the battleground state. The state board of canvassers eventually voted to certify the 2020 election with one Republican board member abstaining at the time.FLORENCE, Italy & BARCELONA, Spain--(BUSINESS WIRE)--Dec 11, 2024-- The Menarini Group ("Menarini"), a leading international pharmaceutical and diagnostics company, and Stemline Therapeutics, Inc. ("Stemline"), a wholly-owned subsidiary of the Menarini Group focused on bringing transformational oncology treatments to cancer patients, along with MEDSIR, a leading global independent clinical research company in oncology and part of Oncoclínicas & Co., the largest specialized oncology treatment group in Latin America, presented research on the pioneering clinical trial ADELA. This important research addresses therapeutic resistance in advanced ER+/HER2- breast cancer. Presented at the San Antonio Breast Cancer Symposium 2024 (SABCS), the study represents a key milestone in the quest for more effective and personalized treatment options for patients with disease progression. The standard first-line treatment for advanced ER+/HER2- breast cancer combines endocrine therapy with CDK4/6 inhibitors. ESR1 mutations develop as a result of prior exposure to endocrine therapy during metastatic treatment, and up to 50% of ER+, HER2- advanced or metastatic breast cancers will develop these mutations. ESR1 mutations cause the tumors to become resistant to endocrine therapy, in turn causing the cancer to progress; therefore, it is important to test for ESR1 whenever mBC progresses. Longer exposure to endocrine therapy during first-line treatment increases the chance of a patient’s tumor developing an ESR1 mutation. With the goal of addressing this unmet medical need, the ADELA phase III clinical trial investigates a new therapeutic option combining elacestrant, a next generation, oral selective estrogen receptor degrader, with everolimus, an mTORC1 inhibitor. This combination is being evaluated in patients with advanced ER+/HER2- breast cancer that harbors ESR1 mutations, and who have experienced progression after standard first-line treatment. Results from the phase III EMERALD study were the basis for elacestrant’s approval. Meanwhile, everolimus has shown efficacy in inhibiting other resistance mechanisms in this type of cancer. The elacestrant and everolimus combination has demonstrated preliminary efficacy with a manageable safety profile in the phase 1b/2 ELEVATE study ( NCT05563220 ). “We at Menarini Stemline are delighted to announce the collaboration with MEDSIR to continue advancing the clinical research to explore the combination therapy with elacestrant,” said Nassir Habboubi, MD, Chief Medical Officer of Stemline Therapeutics. “We are committed to driving innovation in cancer treatment by delivering transformational therapies aiming to extend the lives of people living with cancer.” The primary objective of this international, randomized, double-blind trial is to evaluate whether the combination of elacestrant and everolimus offers greater efficacy in delaying disease progression compared to elacestrant monotherapy. Additionally, it investigates other crucial aspects, such as overall survival, toxicity profile, and the impact on patients’ quality of life. The ADELA study represents a critical step in understanding how to overcome tumor resistance challenges in patients with ESR1 mutations, with the goal of advancing towards more effective and safer treatments. “At MEDSIR, we understand innovation not only as achieving clinical results but as the ability to transform patients' lives on a global scale. With ADELA, we take a decisive step toward accomplishing less invasive and more accessible treatments, aiming to offer new hope to those facing the most complex forms of the disease. This advancement reinforces our commitment to increasingly personalized and patient-centered medicine, a fundamental pillar in shaping the future of oncology,” said Dr. Antonio Llombart-Cussac, Senior Scientific Leader at MEDSIR. The phase III study not only has significant clinical objectives, but also holds the potential to pave the way for regulatory approval of this therapeutic combination, enabling its use in a broader population of patients with advanced breast cancer. Moreover, the international scope of the study, which includes participation from multiple countries, including Spain, Italy, France, Austria, the Czech Republic, Greece, Germany, and the United Kingdom, underscores the study’s global importance and relevance in the scientific community. The presentation of the ADELA study at an event as prominent as SABCS 2024 reinforces MEDSIR’s leadership in excellence-driven oncology research and highlights its focus on addressing unmet needs in breast cancer treatment. The ADELA study is active and already recruiting patients. About ORSERDU (elacestrant) U.S. Indication: ORSERDU (elacestrant), 345 mg tablets, is indicated for the treatment of postmenopausal women or adult men with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, ESR1 -mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy. Full prescribing information for the U.S. can be found at www.orserdu.com . Important Safety Information Warning and Precautions Dyslipidemia : Hypercholesterolemia and hypertriglyceridemia occurred in patients taking ORSERDU at an incidence of 30% and 27%, respectively. The incidence of Grade 3 and 4 hypercholesterolemia and hypertriglyceridemia were 0.9% and 2.2%, respectively. Monitor lipid profile prior to starting and periodically while taking ORSERDU. Embryo-Fetal Toxicity : Based on findings in animals and its mechanism of action, ORSERDU can cause fetal harm when administered to a pregnant woman. Advise pregnant women and females of reproductive potential of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment with ORSERDU and for 1 week after the last dose. Advise male patients with female partners of reproductive potential to use effective contraception during treatment with ORSERDU and for 1 week after the final dose. Adverse Reactions Serious adverse reactions occurred in 12% of patients who received ORSERDU. Serious adverse reactions in >1% of patients who received ORSERDU were musculoskeletal pain (1.7%) and nausea (1.3%). Fatal adverse reactions occurred in 1.7% of patients who received ORSERDU, including cardiac arrest, septic shock, diverticulitis, and unknown cause (one patient each). The most common adverse reactions (≥10%) , including laboratory abnormalities, of ORSERDU were musculoskeletal pain (41%), nausea (35%), increased cholesterol (30%), increased AST (29%), increased triglycerides (27%), fatigue (26%), decreased hemoglobin (26%), vomiting (19%), increased ALT (17%), decreased sodium (16%), increased creatinine (16%), decreased appetite(15%), diarrhea(13%), headache (12%), constipation (12%), abdominal pain (11%), hot flush (11%), and dyspepsia (10%). Drug interactions Concomitant use with CYP3A4 Inducers and/or inhibitors : Avoid concomitant use of strong or moderate CYP3A4 inhibitors with ORSERDU. Avoid concomitant use of strong or moderate CYP3A4 inducers with ORSERDU. Use in specific populations Lactation : Advise lactating women to not breastfeed during treatment with ORSERDU and for 1 week after the last dose. Hepatic Impairment : Avoid use of ORSERDU in patients with severe hepatic impairment (Child-Pugh C). Reduce the dose of ORSERDU in patients with moderate hepatic impairment (Child-Pugh B). The safety and effectiveness of ORSERDU in pediatric patients have not been established. To report SUSPECTED ADVERSE REACTIONS, contact Stemline Therapeutics, Inc. at 1-877-332-7961 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . About The Menarini Group The Menarini Group is a leading international pharmaceutical and diagnostics company, with a turnover of $4.7 billion and over 17,000 employees. Menarini is focused on therapeutic areas with high unmet needs with products for cardiology, oncology, pneumology, gastroenterology, infectious diseases, diabetology, inflammation, and analgesia. With 18 production sites and 9 Research and Development centers, Menarini’s products are available in 140 countries worldwide. For further information, please visit www.menarini.com . About Stemline Therapeutics Inc. Stemline Therapeutics, Inc. (“Stemline”) a wholly-owned subsidiary of the Menarini Group, is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel oncology therapeutics. Stemline commercializes ORSERDU ® (elacestrant) in the U.S. and Europe, an oral endocrine therapy indicated for the treatment of postmenopausal women or adult men with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy. Stemline also commercializes ELZONRIS ® (tagraxofusp-erzs), a novel targeted treatment directed to CD123 for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive hematologic cancer, in the United States and Europe, which is the only approved treatment for BPDCN in the U.S. and E.U. to date. Stemline also commercializes NEXPOVIO ® (selinexor) in Europe, an XPO1 inhibitor for multiple myeloma. Stemline also has an extensive clinical pipeline of small molecules and biologics in various stages of development for a host of solid and hematologic cancers. About MEDSIR Established in 2012, MEDSIR prides itself on working closely with its strategic partners to drive innovation in oncology research. Operating in Spain and the United States, the company provides end-to-end clinical trial management, from study design to publication, with an extensive global network of experts and integrated technology to streamline the process. The company offers proof-of-concept support and a strategic approach that enables research partners to benefit from the best of both worlds: industry clinical research and investigator-driven trials. With the aim of promoting independent research worldwide, MEDSIR has formed a strategic alliance with Oncoclínicas, the leading oncology group in Brazil, which offers outstanding research potential in South America. For further information: www.medsir.org About Oncoclínicas & CO Oncoclínicas&Co is the largest group dedicated to cancer treatment in Latin America, with a specialized and innovative model focused on the entire oncology care journey, combining operational efficiency, humanized care, and high specialization through a medical team composed of over 2,700 specialist physicians with an emphasis on oncology. With its mission to democratize cancer treatment, it offers a comprehensive system that integrates outpatient clinics with high-complexity cancer centers. The company operates 145 units across 39 Brazilian cities, allowing high-quality access in all regions it serves, aligned with world-class standards. Focusing on technology, precision medicine, and genomics, Oncoclínicas performed approximately 635,000 treatments in 2023. It is the exclusive partner in Brazil of the Dana Farber Cancer Institute, affiliated with Harvard Medical School, one of the world’s leading cancer research and treatments centers. The company also owns Boston Lighthouse Innovation, a bioinformatics firm based in Cambridge, United States, and holds shares in Medsir, a company dedicated to the development and management of clinical trials for independent cancer research, based in Barcelona, Spain. Recently, Oncoclínicas expanded its operations to Saudi Arabia through a joint venture with the Al Faisaliah Group, bringing its mission to beat cancer to a new continent and providing advanced oncology care on a global scale by combining oncological hyperspecialization with innovative treatment approaches. The company is part of the IDIVERSA index, launched by B3, highlighting companies committed to gender and racial diversity. For more information, visit: www.grupooncoclinicas.com . View source version on businesswire.com : https://www.businesswire.com/news/home/20241211008868/en/ CONTACT: Media Contacts The Menarini Group Valeria Speroni Cardi Email:pressoffice@menarini.comStemline Therapeutics, Inc. Cheya Pope Email:media@menarinistemline.comGlobal Brand Communication MEDSIR: Sergio Aguilar Global Brand & Communication Director +34 674 82 87 24 sergio.aguilar@medsir.orgEduardo Martín Espallargas Global Communication & Marketing Manager +34 634 835 389 Eduardo.martin@medsir.orgCarles Berloso Cortés International PR & Comms +34 677 49 75 23 carles.berloso@medsir.org KEYWORD: TEXAS SPAIN NORTH AMERICA UNITED STATES EUROPE ITALY INDUSTRY KEYWORD: RESEARCH CLINICAL TRIALS BIOTECHNOLOGY HEALTH PHARMACEUTICAL GENERAL HEALTH OTHER SCIENCE SCIENCE ONCOLOGY SOURCE: The Menarini Group Copyright Business Wire 2024. PUB: 12/11/2024 06:35 PM/DISC: 12/11/2024 06:35 PM http://www.businesswire.com/news/home/20241211008868/en
Walton Goggins has played a number of fun roles throughout his career, but one could argue that he captured audiences attention in a big way through the 2024 TV schedule entry Fallout . The veteran actor played the role of Cooper Howard a.k.a. The Ghoul, and his performance as the cowboy-esque character was met with critical acclaim. Now, Goggins is set to reprise the role for the upcoming second season of one of the best shows on Prime Video . With that, Goggins revealed one reason he’s “really scared” to play the part again, and I totally get it. A major reason why Fallout Season 2 surely remains anticipated amongst fans is because of just how impeccable the first season was. So there are a lot of expectations going into this next stretch of the show’s narrative. However, while discussing the upcoming episodes with EW , Walton Goggins didn’t refer to the high level of excitement amongst viewers as a concern. For the Righteous Gemstones star, it’s the makeup process that’s daunting: I am really scared about getting back into those prosthetics. It’s that old saying where someone asks, ‘Why did you decide to have a second kid?’ Because you totally forgot what it was like to have the first! Honestly, I’m somewhat surprised to hear that this is a concern for the Justified alum, considering one of his recent updates. The star recently posted on Instagram that he was back in the makeup chair for Season 2 , and there was also a photo of prosthetics being applied to his face. He seemed enthusiastic about getting back to work, even declaring that he does “this shit for the love of the game.” With all of that said, though, I can understand the concerns the Ant-Man and the Wasp star has. Walton Goggins’ character comes to stunning life not only because of the actor’s winning portrayal but due to the efforts of skilled makeup artists as well. While promoting Fallout earlier this year, Goggins explained that his transformation into the Ghoul took a long time each day he was on set. He even told CinemaBlend during a separate interview that his southern drawl was even impacted by the prosthetics. It definitely sounds like donning the makeup is no easy task, so his efforts are definitely appreciated. For his performance as the Ghoul, Mr. Goggins has received multiple award nominations, including nods for the Gotham TV Awards, the Saturn Awards and the Astra TV Awards. The actor was also nominated for the Emmy for Outstanding Lead Actor in a Drama Series. On top of all that, many of the critics’ positive takes on the video game adaptation mentioned Goggins’ amazing performance. So I think the hours that the Invincible cast member spends in the makeup chair are worth it. The ending of Fallout Season 1 saw the Ghoul setting out to find the braintrust of Vault-Tec alongside former Vault 33 dweller Lucy MacClean. I’m looking forward to seeing their story continue and for Walton Goggins to jump back into the role of his gun-toting wasteland inhabitant. Also, since Goggins has been through the makeup process quite a bit at this point, let’s hope it’ll be somewhat easier for him as he works on the second season. While you wait for the new episodes, check out the first season of Fallout now using a Prime Video subscription . CINEMABLEND NEWSLETTER Your Daily Blend of Entertainment NewsNoneTrump says US shouldn't intervene in Syria as opposition forces gain ground
HINSDALE — A town landmark recently got a facelift thanks to funds from a nearly $4 million gift from the late Geoffrey Holt. Holt, who did maintenance in the Stearns Mobile Home Park in Hinsdale where he lived and had been a high-school driver’s ed instructor, died in June 2023 at 82. He left his fortune in trust through the N.H. Charitable Foundation to distribute for projects throughout Hinsdale . The Hinsdale clock tower has sat atop the town hall on Main Street since its construction in 1900, according to the Historical Society of Cheshire County. Metal hands now tick across the four faces, in lieu of warped wooden ones that withstood over a century of wind, rain and snow. Over time, pigeons caused damage to the wood, with persistent pecking, according to Town Administrator Kathryn Lynch. “The wooden hands were actually warping and actually curving, and so then they would hit each other at certain times of the day, and it would lose time,” she said. About a year after Holt died, the town received an almost $19,000 award to replace the hands and for costs associated with their repair. The renovations were completed at the end of September. Lynch called the clock tower a “treasure,” and said she frequently consults it for the time. “I think a lot of people like myself, as I drive through town, I always look up to see what time it is.” “A lot of people that enter the town, see the town hall, and it’s just, it’s a big, magnificent building, and the clock tower is just an added piece that’s just very historical.” The clock work is just one example of how the millions Holt left the town is being put to use. He wanted his town to fund projects that advance education, health, recreation and culture for residents. There’s roughly $150,000 per year to be distributed to grant recipients, according to Edwin “Smokey” Smith, one of the fund advisers and a good friend of Holt’s. So far Holt’s gift has funded initiatives such as day scholarships for summer camps, and allowed Cal Ripken baseball to buy gear and the Mount Pisgah ATV Club to improve trails. Additionally, it enabled the Hinsdale Middle/High School to purchase musical instruments, the farmers market to keep vendor prices stable, the town clerk to acquire new ballot equipment, and the recreation committee to get sports equipment, according to Smith. It’s important but nonvital projects like the clock tower that Lynch said the town and its residents have been able to pursue because of the Holt Fund. “The ability to purchase the Town’s wants without producing a tax impact to the Town of Hinsdale’s taxpayers is immeasurable,” Lynch said in an email to The Sentinel. “We are always pushing things aside, like nice new auditorium chairs, to purchase our absolute needs. Mr. Holt’s generous gift granted the Town of Hinsdale the ability to dream and think outside the box. When news of the gift first broke last year, Lynch told reporters clock tower repairs were a project the town might pursue. Philip D’Avanza of D’Avanza Clock Repair in Goffstown did some preliminary work in April and finished the repairs at the end of September. The preservationist has repaired several historic structures since he dove into the world of clock towers in the ‘90s. “If a pair of wooden hands last 100 years, I don’t think you can expect much more,” D’Avanza said. “These few clocks were made back in the 1800s, 1900s, early 1900s. I don’t think anybody anticipated these things to still be around and functioning this long,” he said. “But they have been and they can still keep functioning, and that’s the beauty.” When asked what Holt would have thought of the clock tower repair project, Smith recalled that his good friend was frugal, but not unreasonable. “If it was something of his, he would not have spent this money ... however, the mobile home that he owned, he did replace the windows in it ... he put a new roof on it, and he remodeled the bathroom.” Smith drew a parallel between Holt’s home repairs and those made to the clock tower. “In one respect, he was very frugal,” he said. “In another respect, he knew what had to be done to keep things working, and he did.”Lewandowski double helps Barca to 3-0 win over Brest in Champions League
Jhansi hospital fire: Heads likely to roll as report identifies ‘lapses’