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Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.In the video games, while the character of Indiana Jones is faithfully recreated with attention to detail, there is still a noticeable difference in the level of realism and appeal compared to the real-life portrayal by Harrison Ford. The nuances of Ford's expressions, his body language, and the way he carries himself as Indiana Jones are difficult to fully capture in a digital format, leading to a slightly less engaging and relatable version of the character in the games.50 jilibet 。

Nvidia Market Cap Plummets by 89 Billion Overnight Amid Anti-Monopoly InvestigationThe effectiveness of the Lakers' double-team defense was evident throughout the game, as they forced multiple turnovers and disrupted the Celtics' offensive rhythm. By swarming the ball handler and denying easy passing lanes, the Lakers were able to force difficult shots and create scoring opportunities in transition.NEW YORK (AP) — Thousands of Microsoft 365 customers worldwide reported having issues with services like Outlook and Teams on Monday. In social media posts and comments on platforms like outage tracker Downdetector, some impacted said that they were having trouble seeing their emails, loading calendars or opening other Microsoft 365 applications such as Powerpoint. Microsoft acknowledged “an issue impacting users attempting to access Exchange Online or functionality within Microsoft Teams calendar” earlier in the day. In updates posted on X, the social media platform formerly known as Twitter, the company’s status page said it identified a “recent change” that it believed to be behind the problem — and was working to revert it. Microsoft shared that it was deploying a fix — which, as of shortly before noon E.T., it said had reached about 98% of “affected environments.” Still, the company’s status page later added , targeted restarts were “progressing slower than anticipated for the majority of affected users.” As of midday Monday, Downdetector showed thousands of outage reports from users of Microsoft 365 , particularly Outlook .

In the wake of this incident, our thoughts are with the affected passenger and his family, and we extend our gratitude to the dedicated professionals who worked tirelessly to ensure his well-being. May this serve as a reminder of the importance of preparedness and teamwork in the face of adversity.As the CSI A-Series products continue to attract incremental capital and expand their market presence, the outlook for investors remains optimistic. With a strong emphasis on innovation, diversification, and market access, the CSI A-Series products offer a compelling investment proposition for investors seeking to capitalize on the growth potential of the Chinese market.Cardinals urged to sign Super Bowl winning OG in 2025 | Sporting News

In his emotional interview, Guardiola opened up about the immense pressure he faces on a daily basis and admitted that he often feels overwhelmed by the weight of expectations placed upon him. The 53-year-old coach revealed that he has contemplated walking away from the game altogether, seeking solace and serenity away from the chaos of the football world.The call for President Yoon's arrest stems from a series of alarming allegations that have rocked the foundations of our government. Accusations of corruption, abuse of power, and gross mismanagement have been levied against the highest office in the land, sparking outrage and demands for accountability from citizens and lawmakers alike. As the evidence against President Yoon continues to mount, the need for decisive action to uphold the rule of law and safeguard the integrity of our democracy has become increasingly urgent.

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In recent years, there has been a growing trend towards a rental economy in China, with an increasing number of people opting to rent rather than buy homes. This shift is being driven by changing attitudes towards homeownership, as well as the desire for greater flexibility and mobility. In 2024, we can expect to see this trend continue, with more individuals and families choosing to rent rather than buy property.Moreover, the energy storage industry is also investing in research and development to push the boundaries of technological innovation. By supporting continuous learning and skill development, companies are equipping their employees with the tools and knowledge to stay ahead in a rapidly evolving industry landscape. This commitment to innovation is not only driving advancements in energy storage technologies but also contributing to the growth and competitiveness of the industry as a whole.The arrest of a sitting president is a rare and dramatic move in South Korean politics, and it has sparked widespread protests and unrest across the country. Supporters of President Yoon have taken to the streets to denounce the decision, while opponents have hailed it as a victory for justice and the rule of law.

Even with access to blockbuster obesity drugs, some people don't lose weightBut that's not all – the 2024 Annual Pioneer List also promises a host of surprises and exciting rewards for users. From exclusive discounts on popular apps to special promotions on devices running Original HarmonyOS, there are plenty of incentives for users to get involved and take advantage of everything the operating system has to offer. Whether you're a long-time user or new to the platform, there has never been a better time to explore all that Original HarmonyOS has to offer.

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Inter Milan Set Sights on 26-Year-Old Dutch Defensive Iron, Achterbie Emerges as Top Contender, 3 Giants Vying for Signature8. Poor Communication Skills: Baron Leopold's communication with staff and customers has been characterized by a lack of clarity and consistency, further exacerbating tensions within the postal service.