Trump's lawyers rebuff DA's idea for upholding his hush money conviction
WATCH AS University of Manitoba Political Science professor Royce Koop shares his views in the latest edition of Koop and Klein Inside Politics, expressing frustration with NDP Leader Jagmeet Singh’s approach to the Liberal government. Speaking to The Winnipeg Sun , Koop criticizes Singh’s ongoing public complaints about Liberal policies, pointing out that his party’s support is what keeps the minority government in power. If the NDP is going to criticize the Liberals so forcefully, they need to take responsibility for their role in enabling this government. It’s a contradiction that undermines their credibility. Koop also addressed the pressing issue of crime in Winnipeg, an ongoing concern for residents and businesses. He pushed back against recent claims by some media commentators that little can be done to tackle the rise in violent crime. Governments absolutely can and should take action. Accepting this level of crime as inevitable is a failure of leadership. The impact of violent crime on community life is significant, Koop added. “People don’t feel safe. They stay home. They don’t engage with their community. This hurts not just individuals but the entire social fabric of the city. The conversation highlighted the lack of urgency from all levels of government to address crime effectively. Koop and Klein called for more concrete actions to restore public safety and foster a sense of community in Winnipeg.“There needs to be a focus on solutions,” Koop said. “This isn’t just about enforcing laws; it’s about creating an environment where people feel safe to live, work, and participate in public life. Winnipeg deserves better.”I'm a Celebrity... Get Me Out of Here! fans have hit out at ITV bosses as they accused them of "choosing their winner" already. Eagle eyed viewers have noticed a "campaign" in the jungle show's ad breaks for one certain star. Those watching at home have taken note and hit out that adverts for Coleen Rooney's Wagatha documentary have been showing when the ITV show cuts to a break. The advertisement urges ITV viewers to tune in to Disney+ to watch Coleen Rooney: The Real Wagatha Story, which was released on October 18 of last year. It sees the WAG dressed in a hot pink power suit as she is surrounded by newspaper cuttings. The star holds her phone in her hand, which she used to out fellow footballer's wife, Rebekah Vardy , as Coleen sensationally accused her of selling made up stories to the press in a dramatic social media post. Now, posting on social media, fans have complained about the timing of the ads with some suggesting that they will help Coleen to win the whole show and be crowned Queen of the Jungle. One user wrote: "#ImACeleb I feel like there is a campaign to push Colleen to be Queen of the Jungle especially with the documentary commercials about her. Is it a fix for her to win?" Another added: "Have ITV had to up the number of ad breaks to pay Coleen’s fees?! #ImACeleb." While a third wrote: “Oh these Coleen ad breaks must be a ploy to get her to win the show.” Someone else noted: "We got a Coleen advert while Coleen is in the jungle. #ImACeleb" Elsewhere on the ITV show, other fans have accused bosses of "favouriting" McFly star Danny Jones as he was reunited with his guitar. It comes as the camp mates were tasked with collecting coins in exchange for a luxury item. Dean McCullough received a glitzy dress and Maura Higgins received an apple on her birthday - leaving fans raising their eyebrows over Danny's sentimental item, which featured drawings from his young son on the instrument. Bookmakers have also suggested the singer will win the show. The 38-year-old, who entered the show as the favourite, is once again tipped to win the reality TV show with odds of 10/3 after impressing viewers at home.
UK 'woefully unprepared' for major war as 'reckless' Keir Starmer sent huge warning
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Royal Caribbean Group stock underperforms Monday when compared to competitors
Tweet Facebook Mail A 19-year-old Perth man has been charged with a range of offences and his car impounded after he allegedly performed burnouts near members of the public. On November 18, Western Australia Police became acquainted with vision online that appeared to show a white Ford Falcon ute doing burnouts in the middle of Abernethy Road, Byford, and in a nearby shopping centre carpark. The alleged reckless driving took place on November 16 at about 9.50pm, police say. READ MORE: Woman dies after being found with burns in unit block stairwell Police in Perth impounded a ute they allege was used to do burnouts in a shopping centre carpark. (WA Police) Several wheels and a trolley jack appeared unrestrained in the tray of the ute, and spilled onto the road. Several spectators and members of the public were in the vicinity at the time. On Saturday, November 23, police executed a search warrant at a home in Seville Grove and allegedly found ammunition and the Ford ute. READ MORE: Blackout fears in two states with generators offline for scorching heat The driver had allegedly tried to disguise the car. (WA Police) Police allege the accused tried to conceal the car by removing the tray and spray-painting it a different colour. The ute was impounded. A 19-year-old man has been charged with multiple driving offences and ammo possession. He is due to appear in court on December 4. DOWNLOAD THE 9NEWS APP : Stay across all the latest in breaking news, sport, politics and the weather via our news app and get notifications sent straight to your smartphone. Available on the Apple App Store and Google Play .Paris Hilton’s Ex-Fiancé Arrested After Fighting Cops in Attempted Carjacking
Revolutionary bioengineering research may transform type 1 diabetes care, pave way for tackling cancer and autoimmune disease November 25, 2024 Medical University of South Carolina Researchers recently collaborated on a novel, highly specific strategy to treat type 1 diabetes (T1D) using a tagged beta cell transplant in tandem with localized immune protection provided by specialized immune cells also tagged with a complementary but inert targeting molecule. Facebook Twitter Pinterest LinkedIN Email Regenerative medicine holds the extraordinary promise that future patients in need of new cells, tissues or organs will no longer have to rely on donors. Organ shortages and cell type mismatches will become past problems, replaced by safe, on-demand options for anyone who needs a transplant. This revolutionary field still faces many challenges, including the nontrivial task of convincing stem cells to differentiate into desired cell types for treatment. And even if the correct cells or tissues are created and can function successfully in the body, immune rejection presents a formidable barrier to their use. To overcome this obstacle, regenerative medicine treatments in use today require systemic immunosuppression, leaving patients vulnerable to environmental hazards like viruses, bacteria and cancer cells. In a novel approach to tackle these obstacles, researchers at the Medical University of South Carolina and the University of Florida recently collaborated on a novel, highly specific strategy to treat type 1 diabetes (T1D) using a tagged beta cell transplant in tandem with localized immune protection provided by specialized immune cells also tagged with a complementary but inert targeting molecule. According to Leonardo Ferreira, Ph.D., a researcher at MUSC Hollings Cancer Center and one of the principal investigators on the study, marrying stem cell engineering and regulatory T cell (Treg) engineering allowed the first step toward a readily available, off-the-shelf solution to treating T1D. In their recent study published in the journal Cell Reports , the researchers described a unique collaboration that leveraged the beta cell engineering expertise of the lab of Holger Russ, an associate professor of pharmacology and therapeutics at the University of Florida, combined with the delicate surgical expertise and chimeric antigen receptor (CAR) T cell expertise available at Hollings. For T1D patients, the trouble begins with an immune system self-attack on pancreatic beta cells, the cells that produce the hormone insulin to regulate blood sugar levels. Without a reliable way to self-regulate blood glucose levels, patients are forced to live with a high-maintenance regimen of glucose monitoring and insulin management to maintain health and avoid dangerous complications like neuropathy, amputation and blindness. For now, some patients with poorly controlled T1D may consider islet cell transplantation using beta cells from a donor. Beta cells are isolated from a donor pancreas, purified and delivered to the patient's liver, where they can take up residence and begin secreting insulin. However, this option requires patients to undergo immunosuppression for the rest of their lives to keep the body from rejecting the foreign beta cells. It also requires the availability of donor cells, which might require long waits or may not happen at all. To focus on an alternative solution, the researchers used an engineering strategy with tagged beta cells generated from stem cells. And to induce localized immune protection, the researchers chose to use Tregs, a type of immune cell that monitors and controls the immune response. "Most of the cells of the immune system are focused on killing invasive elements," Ferreira said. "But Tregs are the generals of the immune system. They make sure that nothing goes overboard, and they train the immune system on how to respond in the future." The researchers used a mouse model to test their strategy. By transplanting beta cells that were engineered from stem cells and included a nonreactive tag -- an inactivated version of epidermal growth factor receptor -- into the kidney capsules of immunodeficient mice, they showed that the cells were incorporated and began to manufacture functional insulin. In the next phase of testing, the mice were exposed to an aggressive type of immune cell to check on the viability of the transplanted beta cells in the face of a simulated immune response. As expected, all of the beta cells were killed by the immune response, the same thing that happens in people with T1D. To avoid the killing response in the next phase, the researchers added specialized Tregs along with the immune challenge. These cells were tagged with CAR technology using a receptor that specifically recognized the inert EGFR tag present on the transplanted beta cells. With this added step, the researchers observed the immune protection they hoped for, as they observed the transplanted beta cells remaining safe, sound and functional in their new home. Ferreira was delighted with the results and energized to take the next steps. "With this approach," he said, "we made both the lock and the key for creating immune tolerance." Now that Ferreira and colleagues have shown the feasibility of their approach to T1D treatment, they plan to continue their research efforts, including building a whole library of locks and keys -- differentiated stem cells and tagged protective Tregs -- for multiple purposes, such as targeting certain cancers, lupus and other autoimmune diseases. A few questions remain, such as the specific ligand that should be used for human transplantation and the longevity of Treg-mediated immune protection. The ligand or tag must be inert and have no negative impact on the function of the cells or create any reaction that could cause side effects. And it is still unknown if one Treg treatment will be effective or might need to be repeated at intervals that have yet to be established. Because Tregs can educate immune cells to maintain immune tolerance, it is possible that one treatment will be adequate, but further research is needed to understand the long-term effects. Answering these questions and confirming the validity of the approach in humans may soon transform T1D from a chronic, high-maintenance disease with many complications to one that can be managed much more easily. Story Source: Materials provided by Medical University of South Carolina . Original written by Shawn Oberrath. Note: Content may be edited for style and length. Journal Reference : Cite This Page :NoneGATORS PODCAST: Gators keep good times rolling with upset of Ole Miss (Ep. 259)Ant McPartlin's ex Lisa Armstrong shares sweet baby news
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Stocks slipped in afternoon trading Friday as Wall Street closes out a rare bumpy week. The S&P 500 dropped by less than 0.1% and is on track for a loss for the week after three straight weekly gains. The Dow Jones Industrial Average fell 25 points, or 0.1% to 43,884 as of 2:11 p.m. Eastern time. The Nasdaq rose less than 0.1% and is hovering around its record. Broadcom surged 22.1% for the biggest gain in the S&P 500 after the semiconductor company beat Wall Street’s profit targets and gave a glowing forecast, highlighting its artificial intelligence products. The company also raised its dividend. The company's big gain helped cushion the market's broader fall. Pricey stock values for technology companies like Broadcom give the sector more weight in pushing the market higher or lower. Artificial intelligence technology has been a focal point for the technology sector and the overall stock market over the last year. Tech companies, and Wall Street, expect demand for AI to continue driving growth for semiconductor and other technology companies. Even so, some big tech stocks were in the red Friday. Nvidia slid 2.4%, Meta Platforms dropped 2% and Netflix was down 1%. Furniture and housewares company RH, formerly known as Restoration Hardware, surged 13.8% after raising its forecast for revenue growth for the year. Wall Street's rally stalled this week amid mixed economic reports and ahead of the Federal Reserve's last meeting of the year. The central bank will meet next week and is widely expected to cut interest rates for a third time since September. Expectations of a series of rate cuts has driven the S&P 500 to 57 all-time highs so far this year . The Fed has been lowering its benchmark interest rate following an aggressive rate hiking policy that was meant to tame inflation. It raised rates from near-zero in early 2022 to a two-decade high by the middle of 2023. Inflation eased under pressure from higher interest rates, nearly to the central bank's 2% target. The economy, including consumer spending and employment, held strong despite the squeeze from inflation and high borrowing costs. A slowing job market, though, has helped push a long-awaited reversal of the Fed's policy. Inflation rates have been warming up slightly over the last few months. A report on consumer prices this week showed an increase to 2.7% in November from 2.6% in October. The Fed's preferred measure of inflation, the personal consumption expenditures index, will be released next week. Wall Street expects it to show a 2.5% rise in November, up from 2.3% in October. The economy, though, remains solid heading into 2025 as consumers continue spending and employment remains healthy, said Gregory Daco, chief economist at EY. “Still, the outlook is clouded by unusually high uncertainty surrounding regulatory, immigration, trade and tax policy,” he said. Treasury yields edged higher. The yield on the 10-year Treasury rose to 4.39% from 4.34% late Thursday. European markets slipped. Britain's FTSE 100 fell 0.1%. Britain’s economy unexpectedly shrank by 0.1% month-on-month in October, following a 0.1% decline in September, according to data from the Office for National Statistics. Asian markets closed mostly lower.
The Chicago Blackhawks are going to be without Laurent Brossoit for even more time then initially expected. On Friday, Blackhawks head coach Luke Richardson updated that Brossoit had underwent a second surgery on his right knee and is expected to miss at least six more weeks. The Blackhawks signed Brossoit this past offseason , one of their major acquisitions to help boost the team. Unfortunately fans have not had an opportunity to see Brossoit in a Blackhawks uniform as a summer injury turned into Brossoit missing the preseason, but expected to come back within a few weeks. Then, after hearing very little and seeing Brossoit on the ice practicing just a few times, the Hawks have now updated that Brossoit would be out for even more time. Brossoit missing at least six more weeks puts his return to play now in the middle of January. That could have a major impact on the Hawks roster, especially in the crease. How Laurent Brossoit’s injury impacts the Blackhawks With Brossoit out for six more weeks, the Blackhawks will need to lean on Arvid Soderblom and Petr Mrazek in the meantime. Entering the season, Mrazek and Brossoit looked to be a great tandem and a major improvement over last season’s pairing of Mrazek and Soderblom. In Brossoit’s absence, Soderblom has stepped up to the challenge, posting a .926 save percentage and a goals against average of 2.36. That is a major improvement from last season where in 32 games Soderblom registerd a 3.92 goals against average and s ave percentage of just .880. Across 29 starts last season, Soderblom played in just five wins, with a record of 5-22-2. Soderblom being with the Hawks into January will impact his waiver status as he is four games away from 60 career games played and will then no longer be waiver exempt. So, once Brossoit does return, it is likely Chicago will have to carry three goaltenders as Soderblom would not clear waivers if he was sent down, especially with so many teams struggling with injuries in the crease. The Hawks carrying three netminders would take up an additional roster spot that could go to a seventh defenseman or 13th forward, which would complicate things for Chicago. Kyle Davidson signed Brossoit to a two year contract carrying a $3.3 million cap hit this summer. Brossoit, 31, missing so much time definitely is a loss for the franchise. Last season, Brossoit played in 23 games with the Winnipeg Jets and registered a career best .927 save percentage. It looked like Brossoit and Mrazek would form a really strong duo, both capable of potentially working as a true 1A 1B tandem, not a traditional starter backup. With Brossoit out for another month plus, expect Soderblom to get a bigger opportunity to play. So far he has started in just six games, and now the Hawks might as well use this time to see if he can be a potential starter long term. This article first appeared on Chicago Hockey Now and was syndicated with permission.Chris Logan out as UND soccer coach
Newmont's EVP Peter Toth sells $124,770 in common stockBLOUNTVILLE – It was a tough start for Carter Jones and West Ridge, but the Wolves were howling at the end of the night. Jones scored 13 of her game-high 17 points in the second half to help West Ridge to 62-52 season-opening Hall of Champions victory over Cocke County on a bitterly cold Friday night outside of Evelyn Rafalowski Athletic Complex. West Ridge (1-0) outscored the Lady Red 22-6 in the fourth quarter to pull away from a squad that advanced to the Class 3A state semifinals last season. "That is a very good team," West Ridge head coach Kristi Walling said, "a lot of good players, they are well coached, that is a big win for us, that is a very good team." Playing their up-tempo style of play, the Wolves led the entire first half, taking a 19-14 lead after one quarter and 28-23 going into the halftime break. Foul trouble prevented Jones from staying on the floor, but that changed after the break. "She couldn't get in the rhythm there in the first because she got two fouls early so she had to sit and go in and come in and out, couldn't really get in a rhythm," Walling said. "I was proud of her for stepping up big there in the second half." West Ridge got nine 3-pointers for five different players, including three by Randi Smith and two each from Jones and freshman Addison Bunn, who had 14 points in her varsity debut. "She did a great job for us. She hit some big shots for us and did a good job on defense." Walling said. "I am super proud of all the kids, every kid that came in tonight contributed." Cocke County (1-1) fought back in the third period, taking its first lead at 33-32 with 4:28 to go in the third quarter. That margin grew to as much as eight before taking a 46-40 in the final period, led by Karmine Carmichael, who paced the Fighting Cocks with 16 points, and Shakira Reed, who added 11. "We switched up our defensive strategy there in the third a little bit, kind changed things a little bit and I think that really helped," Walling said. It was all Wolves from that point, taking the lead back on 3s by Millie Shelton and Jones and a short jumper from Allie Reilly to put West Ridge up to stay. "It was back and forth. That is what I love about this team, they never give up," Walling said. "They are going to fight back, they work hard, they come in every day at practice and work hard. They are great kids to be around, I enjoy being around them every day." Smith added nine points for the Wolves, while Shelton had eight, including a running jumper to put the Wolves up 50-47 with 5:06 to play as the Wolves ran the floor much of the night, which is what Walling wants from her squad this season. "That is our thing this year," she said. "We kind of like to run so we have to be in condition to be in shape because that is our game plan." BOYS West Ridge 66, Cocke County 60 Avery Horne canned four 3-pointers, including three in the third quarter, and finished with 27 points to lead the Wolves to a season-opening victory over the Fighting Cocks. Led by 6-foot-6 Kyler Hayes, Cocke County rallied from a 14-11 deficit after one quarter to take a 32-26 lead into the break. West Ridge (1-0) was able to use the 3-point shot to get ahead of the Fighting Cocks, canning six of them. Horne had three of his four 3s in his own 13-point third quarter for the Wolves. Trey Frazier added 12 points for West Ridge, while Leming and Eli Bright hit late free throws in the final 32 seconds to secure the win. Ethan Fine led the Fighting Cocks (0-2), which dropped a two-point decision against Elizabethton on Wednesday, with 21 points, while Hayes finished with 17. Trent Tatum added eight points and Dylan Bannan had six for West Ridge head coach John Dyer, who picked up his 613th career win in what is the start of his 40th season as a head coach, having also been at Sullivan East and Johnson County.
SANTA CLARA, Calif. (AP) — De’Vondre Campbell’s decision to quit on his team in the middle of a game overshadowed the bigger issues for the San Francisco 49ers. An offense that was one of the most dynamic in the NFL during a run to the Super Bowl last season has been just ordinary for most of 2024 and was downright bad in a 12-6 loss to the Los Angeles Rams on Thursday night that just about ended San Francisco’s playoff hopes. San Francisco (6-8) was held to its fewest yards (191) in a regular-season game in eight seasons under coach Kyle Shanahan and its fewest points since Shanahan’s debut in 2017 on a rainy night that will be remembered mostly for Campbell walking off the field in the middle of the game with a towel draped over his head. The game also featured San Francisco going three-and-out on four drives as Brock Purdy struggled to connect with his receivers. Deebo Samuel dropped a potential touchdown pass after complaining earlier in the week about a lack of touches. Purdy then missed Ricky Pearsall on an underthrown deep shot in the fourth quarter before throwing an interception into the end zone that ended the Niners’ comeback attempt. RELATED COVERAGE Sean McVay’s Rams are on a roll toward the playoffs after 2 big wins in a 5-day stretch Pro Football Hall of Famer Randy Moss reveals cancer diagnosis, 6-hour surgery Jets running back Hall ‘looks promising’ to play vs. Jags, but cornerback Reed is doubtful “I just feel like I had a lot of plays left out there that I could have made for our team,” Purdy said. “I thought the defense and special teams played so good. That’s what’s hurting me is I just feel like I failed the team. I could have been better for our offense and we could have put up more points.” Scoring has been an issue this season for the 49ers, who have been missing key playmakers like Christian McCaffrey and Brandon Aiyuk for much of the season. San Francisco is scoring 8.5 fewer points per game on offense than the Niners did through 14 games last season. The AP Top 25 college football poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . What’s working Red-zone defense. After allowing touchdowns on 13 consecutive red-zone drives over the previous four games, the 49ers kept the Rams out of the end zone on all three drives that went inside the 20. What needs help Receivers. The 49ers failed to get much production from their wide receivers with Purdy going 6 for 20 for 63 yards with an INT and a 19.4 rating when targeting wideouts. Samuel had 16 yards on seven targets with the key drop. Jauan Jennings had two drops and was the target on the interception. Pearsall had one catch for 16 yards on four targets. Stock up LB Dre Greenlaw returned for the first time since tearing his left Achilles tendon in last season’s Super Bowl. Greenlaw had eight tackles in the first half as he brought needed intensity and physical play that had been missing for much of the season. Stock down Campbell. The 49ers are deciding whether to waive or suspend Campbell, who lost his starting job when Greenlaw returned and then refused to play when he was needed. “His actions from the game just is not something you can do to your team or your teammates and still expect to be a part of our team,” Shanahan said. “We’re working through exactly the semantics of it right now, but we’ll handle the situation appropriately.” Injuries Greenlaw came out of the game feeling OK after leaving with soreness in his knee and Achilles tendon. He is day to day. ... S Ji’Ayir Brown (groin) and LB Dee Winters (neck) are also day to day. ... LT Trent Williams (ankle) is still trying to get back to play after missing the last four games. Shanahan said Williams’ recovery has been “a lot slower than anticipated.” Key number 0 — The Niners didn’t reach the red zone once all game, with their deepest penetration into Rams territory being when they reached the 27 on a third-quarter field goal drive. This marked the first time since Week 11 in 2010 that the 49ers didn’t run a single play inside the opponent’s 25. What’s next The 49ers visit Miami on Dec. 22. ___ AP NFL: https://apnews.com/hub/NFLOn Friday night, Iowa defeated Nebraska by a final score of 13-10 thanks to a game-winning field goal from Drew Stevens. Unfortunately, fans watching this rivalry game at home didn't get to see the kick go through the uprights. For some inexplicable reason, NBC's camera work for the final kick of the Nebraska-Iowa game was so high that you couldn't see where Stevens' attempt landed. All you heard was the announcer say, "Got it! Hawks win!" Obviously, the crowd's reaction to the kick was a dead giveaway that Stevens made his attempt from 53 yards out. That being said, NBC isn't above criticism. The fact that viewers at home couldn't enjoy this epic moment is ridiculous. Check out the camera work from NBC: HAWKEYES WIN! WHAT A FINISH! #B1GFootball pic.twitter.com/NudcU1ZSWx Countless fans ripped NBC on social media for this blunder, and rightfully so. "Drug test your camera guy please," a fan tweeted. "Apparently the practice kick didn’t help the camera op. Did the same thing twice. You hate to see it," a second fan said. "Horrid camera work," a social media user commented. "Put me in the group who would like to see NBC give their camera guys some equipment education. All night just terrible angles," one person added. "NBC should lose all rights to Big Ten football after not getting the camera shot right on Iowa's game-winning field goal," another person wrote. Icon Sportswire/Getty Images Stevens was asked about his game-winning field goal after the game. As you'd imagine, he was fired up about it. “It means everything,” Stevens told reporters . “I was looking forward to this game. I can say that now. ... This one felt really good.” With the win over Nebraska this week, Iowa improved to 8-4 on the season. Related: Nebraska Players Refuse To Shake Hands With Iowa, Lose Game In Heartbreaking Fashion
Paychex Inc. stock underperforms Wednesday when compared to competitorsA young woman has taken to the social media platform X to share a touching story about how her mother met and married her father 38 years ago. She shared the story while contributing to a thread on how people's parents met each other. According to her, her mum was a widow from an abusive marriage and had a five-year-old son. Her dad at the time was in his 40s and was keen on never getting married, stating he would only concede to marriage if the woman was a widow or divorcee. She said an aunt who badly wanted her father to get married introduced him to her mum and they have since lived happily. The X user said when asked why a widow, her father told her mum that being a widow wasn't her fault and that she deserved happiness. Read the heartwarming story below.
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