No. 6 Purdue routs Marshall
Blood disorders affect millions worldwide—an estimated 5% of the global population suffers from conditions like anemia, and others. Anemia is a silent epidemic, with over 2 billion people affected globally, often caused by iron deficiency or chronic diseases. With ongoing research, the treatment landscape for blood disorders continues to evolve, from targeted therapies to life-saving gene editing technologies. LAS VEGAS , Dec. 9, 2024 /PRNewswire/ -- Blood disorders are a group of conditions that affect the production, function, or structure of blood cells, leading to various health complications. These disorders can involve issues with red blood cells, white blood cells, platelets, or the plasma components of blood. Common types of blood disorders include anemia, where there is a deficiency of red blood cells or hemoglobin, leading to fatigue and weakness, and thrombocytopenia, characterized by low platelet counts, which can cause excessive bleeding. The causes of blood disorders range from genetic factors and autoimmune conditions to infections and environmental factors. Treatment options depend on the specific disorder and may include medications, blood transfusions, or bone marrow transplants. DelveInsight has recently released a series of epidemiology-based market reports focusing on blood disorders including Immune Thrombocytopenia, Aplastic Anemia, and Diamond-Blackfan Anemia . These reports include a comprehensive understanding of current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted market size from 2020 to 2034 segmented into 7MM [ the United States , the EU-4 ( Italy , Spain , France , and Germany ), the United Kingdom , and Japan ]. Additionally, the reports feature an examination of prominent companies working with their lead candidates in different stages of clinical development. Let's deep dive into the assessment of these blood disorders markets individually. Immune Thrombocytopenia Market Immune thrombocytopenic purpura (ITP) is an autoimmune condition marked by a low platelet count, resulting in bruising and bleeding. It manifests as acute in children and chronic in adults. The primary treatments are corticosteroids, intravenous immunoglobulin (IVIg), and rituximab. In the 7MM, the United States reported the highest prevalence of ITP, with nearly 66,500 cases in 2023. Primary ITP, which accounts for 80% of cases, occurs without any underlying diseases, while secondary ITP, making up about 20% of cases, is linked to conditions such as systemic lupus erythematosus (SLE), medications, infections, and other autoimmune diseases. In immune thrombocytopenia, the initial treatment generally consists of corticosteroids, with prednisone prescribed at 1 mg/kg/day for 21-28 days, followed by a gradual taper. High-dose dexamethasone (40 mg/day for 4 days) may lead to a more pronounced platelet response. Intravenous immunoglobulin (IVIG) or intravenous anti-D (Rho[D] immune globulin) may be used as first-line options, particularly in urgent situations requiring quick platelet increases. However, many adults experience relapses or do not respond to first-line therapy, necessitating second-line treatments. IVIG is effective in 70-80% of cases, and anti-D works in 50-70% of RhD-positive patients. Splenectomy is a well-established second-line option, though it carries risks such as infection and bleeding. Rituximab , a monoclonal antibody that targets CD20, has shown strong efficacy both before and after splenectomy. Thrombopoietin-receptor agonists, such as romiplostim and eltrombopag, are also effective second-line treatments as they promote platelet production by activating the thrombopoietin receptor. In the US, the approved treatments for ITP are DOPTELET, TAVALISSE, PROMACTA, and NPLATE . The EU market for thrombocytopenia is primarily driven by both approved and off-label therapies. In the EU, approved treatments include DOPTELET (avatrombopag), TAVALISSE/TAVLESSE (fostamatinib), PROMACTA/REVOLADE (eltrombopag), and NPLATE/Romiplate (romiplostim) . RITUXAN is only approved in Japan for the treatment of ITP. Learn more about the FDA-approved drugs for ITP @ Drugs for Immune Thrombocytopenic Purpura Treatment As per DelveInsight analysis, in 2023, the total ITP market size in the 7MM was USD 3.1 billion . As per the estimates, PROMACTA (eltrombopag) achieved the highest revenue among all medications in the 7MM in 2023. The market is expected to show positive growth, mainly attributed to the increasing cases and also, the launch of upcoming therapies during the forecast period (2024–2034). Immune Thrombocytopenic Purpura Pipeline Therapies and Key Companies Rilzabrutinib (PRN-1008): Sanofi/Principia Biopharma Mezagitamab (TAK-079): Millennium Pharmaceuticals/Takeda Efgartigimod (ARGX-113): argenx BT-595: Biotest Dive deeper for rich insights into the Immune Thrombocytopenic Purpura Clinical Trials Aplastic Anemia Market Aplastic anemia is a rare and serious non-cancerous condition marked by the autoimmune destruction of early blood-forming cells. The global incidence varies from 0.7 to 7.4 cases per million people annually, with higher rates observed in Asia compared to Europe and the United States . As per DelveInsight estimates, the total Incident population of aplastic anemia in the 7MM were around 2,500 cases in 2023. These cases are projected to increase during the forecast period. Based on severity, severe and very severe aplastic anemia patients contributed roughly 65%-80% of the total aplastic anemia patient population. HSCT remains the standard treatment for patients under 40 years old, while Immunosuppressive Therapies (IST) are the preferred approach for patients aged 40 and above. In terms of pharmacological treatments, Novartis' PROMACTA/REVOLADE is currently the leading revenue driver, followed by ISTs across the 7MM. According to Novartis, the primary revenue drivers for PROMACTA/REVOLADE are its use in patients with chronic immune thrombocytopenic purpura (ITP) and severe aplastic anemia (SAA). PROMACTA was first approved in 2014 for use in relapsed/refractory SAA patients in the United States , with approvals following in Europe in 2015 and Japan in 2017. However, it was approved for use as a first-line treatment in combination with ISTs like ATG in the US in 2018, which expanded treatment options for first-line patients and contributed to increased revenue. The total aplastic anemia market size was found to be ~USD 270 million in 2023 in the 7MM, which is further expected to increase by 2034 due to several factors such as an increase in disease incidence in Asian countries, high patient uptake of PROMACTA (until expected patent expiry in 2025), approval of Teva Pharma's ALVAIZ in the US, and Kyowa Kirin's ROMIPLATE in Japan along with the expected launch of potential emerging therapies. Aplastic Anemia Pipeline Therapies and Key Companies REGN7257: Regeneron Pharmaceuticals OMISIRGE (omidubicel): Gamida Cell For a comprehensive view of the aplastic anemia market, check out the Aplastic Anemia Market Assessment Diamond-Blackfan Anemia Market Diamond-Blackfan anemia (DBA) is a rare genetic condition that primarily disrupts the bone marrow's ability to produce red blood cells, resulting in severe anemia. It is typically diagnosed during infancy or early childhood and presents with symptoms such as pale skin, fatigue, stunted growth, and physical abnormalities, which may include thumb deformities or heart defects in certain cases. In 2023, there were around 7,870 reported cases of Diamond-Blackfan anemia across the 7MM, with the United States accounting for about 70% of these cases. Within the US, approximately 46% of cases in 2023 were linked to mutations in the RPS19 gene , which plays a crucial role in ribosomal protein synthesis, contributing to its high prevalence in DBA. Diamond-Blackfan anemia is frequently associated with several congenital anomalies, with craniofacial and musculoskeletal defects being the most common. Craniofacial abnormalities were noted in over 30% of DBA patients across the 7MM in 2023. Although DBA has a significant impact on patient health, there are currently no FDA-approved treatments available for the condition. Treatment primarily involves corticosteroid combinations, chronic blood transfusions, iron chelation, and potentially curative hematopoietic stem cell transplantation (HSCT). In 2023, the total market size for Diamond-Blackfan anemia was USD 1.56 million in the 7MM and is projected to increase by 2034. The United States represents the largest share of the Diamond Blackfan Anemia market, accounting for a significant proportion compared to the EU4 ( Germany , Spain , Italy , France ), the United Kingdom , and Japan . In 2023, corticosteroids were the leading therapy for DBA, generating USD 1.1 million in revenue, making them the preferred first-line treatment option. Since there are no FDA-approved therapies available and no emerging companies are working to fill this gap, there is a significant opportunity for innovative treatments, like gene therapy, to make a meaningful difference and address the needs of DBA patients. For a deeper understanding of the Diamond-Blackfan anemia market landscape, explore the Diamond-Blackfan Anemia Market Outlook Trending Hematological Disorders Reports Multiple Myeloma Market Multiple Myeloma Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key multiple myeloma companies, including Johnson & Johnson (Janssen) , Pfizer, AbbVie and Roche (Genentech), Regeneron Pharmaceuticals, Bristol-Myers Squibb, Celgene, Roche (Genentech), Arcellx, Novartis, Regeneron Pharmaceuticals, BeiGene, CARsgen Therapeutics, Cartesian Therapeutics, C4 Therapeutics, Heidelberg Pharma, Bristol-Myers Squibb, RAPA Therapeutics, AbbVie (TeneoOne), Takeda , among others. Sickle Cell Disease Market Sickle Cell Disease Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key sickle cell disease companies, including Vertex Pharmaceuticals, CRISPR Therapeutics, Bluebird Bio, Global Blood Therapeutics, Pfizer , among others. Beta-Thalassemia Market Beta-Thalassemia Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key beta-thalassemia companies, including Novartis, Merck, Bristol Myers Squibb, Chiesi Farmaceutici S.p.A, Bluebird Bio, Agios Pharmaceuticals, Imara Inc., CRISPR Therapeutics, Vertex Pharmaceuticals, Vifor Pharma, Ionis Pharmaceuticals, Forma Therapeutics, DisperSol Technologies, SILENCE Therapeutics , among others. Warm Autoimmune Hemolytic Anemia Market Warm Autoimmune Hemolytic Anemia Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key wAIHA companies, including Zenas BioPharma, Sanofi, Johnson & Johnson, Novartis Pharmaceuticals, Incyte Corporation, Rigel Pharmaceuticals, Alpine Immune Sciences, Inc., Hutchison Medipharma Limited , among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Contact Us Shruti Thakur info@delveinsight.com +14699457679 www.delveinsight.com Logo: https://mma.prnewswire.com/media/1082265/3528414/DelveInsight_Logo.jpg
Moreover, the exposure gained from competing in the Club World Cup will further elevate the profiles of Manchester City and Chelsea on the global stage. As two of the most successful and popular clubs in the Premier League, their participation in the tournament will attract a large international audience and showcase the quality of English football to a wider audience.In the Game of the Year category, nominees such as "The Last of Us Part II," "Hades," and "Animal Crossing: New Horizons" are among the top contenders. Each game has received critical acclaim for its innovative gameplay, captivating story, and stunning visuals, making it a tough choice for voters to decide on a winner.The conflict between Israel and Iran has been escalating in recent months, with each side accusing the other of carrying out provocative actions. Israel has repeatedly warned against Iran's presence in Syria, where it supports the Syrian government in the ongoing civil war.
In conclusion, the exposure of "petty greed and corruption" within the education system is a sobering reminder of the challenges society faces in maintaining ethical standards and combating corruption. It is a call to action for all citizens to remain vigilant and work towards a more transparent and accountable society, where integrity and honesty prevail. Only through collective effort and unwavering commitment can we hope to build a brighter future for generations to come.
Guest Opinion: K-12 digital education must involve inclusion, accessibilityNew ancient pyramid found at the side of a road part of settlment around 14,000 years old
COLUMBUS, Ohio — Will Howard passed for two touchdowns and rushed for another, TreVeyon Henderson ran for a score and No. 2 Ohio State beat previously undefeated No. 5 Indiana 38-15 on Saturday. All Ohio State (10-1, 7-1 Big Ten, CFP No. 2) has to do now is beat Michigan at home next Saturday and it will earn a return to the Big Ten championship game for the first time since 2020 and get a rematch with No. 1 Oregon. The Ducks beat Ohio State 32-31 in a wild one back on Oct. 12. The Hoosiers (10-1, 7-1, No. 5 CFP) had their best chance to beat the Buckeyes for the first time since 1988 but were hurt by special teams mistakes and disrupted by an Ohio State defense that sacked quarterback Kurtis Rourke five times. “In life, all good things come to an end,” Indiana coach Curt Cignetti said. Late in the first half, Indiana punter James Evans fumbled a snap and was buried at his own 7-yardline with the Buckeyes taking over. That turned quickly into a 4-yard TD run by Henderson that gave the Buckeyes a 14-7 lead. Early in the second half, Caleb Downs fielded an Evans punt at the Ohio State 21, raced down the right sideline, cut to the middle and outran the coverage for a TD that put the Buckeyes up 21-7. It was the first time a Buckeye returned a punt for a touchdown since 2014. Howard finished 22 for 26 for 201 yards. Emeka Egbuka had seven catches for 80 yards and a TD. “Our guys just played with a chip today, and that’s the way you got to play the game of football,” Ohio State coach Ryan Day said. Indiana scored on its first possession of the game and its last, both short runs by Ty Son Lawson, who paced the Hoosiers with 79 rushing yards. Rourke was 8 for 18 for 68 yards. “We had communication errors, pass (protection), every time we dropped back to pass, something bad happened," Cignetti said. Indiana's 151 total yards was its lowest of the season. And it was the most points surrendered by the Hoosier's defense. Indiana: Its special season was blemished by the Buckeyes, who beat the Hoosiers for the 30th straight time. Indiana was eyeing its first conference crown since sharing one with two other teams in 1967. That won't happen now. “Ohio State deserved to win,” Cignetti said. “They had those (third quarter scores), and we just couldn’t respond.” Ohio State: Didn't waste the opportunities presented by the Hoosiers when they got sloppy. The Buckeyes led 14-7 at the break and took control in the second half. An offensive line patched together because of multiple injuries performed surprisingly well. “We know what was at stake," Day said. “We don't win this game, and we have no chance to go to Indianapolis and play in the Big Ten championship. And that's real. We've had that approach for the last few weeks now, more than that.” Some voters were obviously unsure of Indiana because it hadn't played a nationally ranked team before Ohio State. After this one, the Hoosiers will drop. Howard made history by completing 80% of his passes for the sixth time this season. No other Ohio State quarterback has done that. He completed his first 14 passes in a row and finished with a 85% completion rate. “I think Buckeye nation is now seeing, after 11 games, that this guy is a winner, he's tough, he cares about his teammates, he's a leader,” Day said. Indiana hosts Purdue in the regular-season finale next Saturday. Ohio State hosts rival Michigan on Saturday. Copyright 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission. Get local news delivered to your inbox!City closes pedestrian bridge over Rideau River for winter use