HUNTSVILLE, Ala. (AP) — Paul Zilinskas put up 32 points as IU Indianapolis beat Alabama A&M 88-83 on Monday. Zilinskas shot 11 for 20 (5 for 10 from 3-point range) and 5 of 5 from the free-throw line for the Jaguars (3-5). Jarvis Walker scored 13 points while going 3 of 9 from the floor, including 2 for 5 from 3-point range, and 5 for 7 from the line. Timaris Brown and Sean Craight both added 11 points. Darius Ford led the Bulldogs (4-4) in scoring, finishing with 20 points, six rebounds, seven assists and two steals. Anthony Bryant added 17 points for Alabama A&M. Chad Moodie also had 16 points and three blocks. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
Nasdaq surges above 20,000 after US inflation data matches estimates
Article content Re: “ Dubé lays down law for new MDs ” (The Gazette, Dec. 5) Just as the pen is mightier than the sword, the carrot is superior to the stick. And yet, Health Minister Christian Dubé’s proposed solution for steering new doctors away from the private sector and into the public system is to use legislative force and lock the door for a minimum of five years. The better idea: Improve work conditions so physicians experience satisfaction and fulfilment in their role and, thus, will want to choose the public system. Nick Di Cino, Ahuntsic-Cartierville Re: “ Santé Québec isn’t the cure for what ails health care ” (Allison Hanes, Nov. 20) I would tend to go along with Allison Hanes and bet nothing will change for the better in the health-care system under Santé Québec. Why is it that the government seems to get it wrong time and time again? Is it, as Hanes suggests, because the effort to overhaul health care is focused on structures rather than services? Timely and efficient services are what Quebecers need and what medical professionals are trained to provide. It’s been far too long now that we hear mostly of problems and too little about workable solutions. Goldie Olszynko, Mile End Re: “ On the critical list: Study urges doctors to never use these phrases with patients ” (NP Montreal, Nov. 14) As a former board certified oncology social worker at a major teaching hospital in Montreal, I can attest to how much words and phrases matter. All too often, patients who feel anxious and vulnerable are subjected to words and/or phrases spoken by their health-care provider that exasperate their sense of hope and renders them even more concerned and fearful for their future. It has been my experience when patients and their families find themselves in a clinical setting they are generally known to hang on to every word the doctor says. Therefore, I feel it incumbent upon the physician to always be aware that regardless of the prognosis, healing is a process that continues until one’s very last breath. Thus, doctors best heed the wisdom and advice spelled out in the book Whole Person Care (Tom A. Hutchinson, editor) by Dr. Abraham Fuks, who writes: “The skein of recognition, commitment, and directedness toward the other that can relieve suffering and permit healing is spun by language and knotted by words.” Brahms E. Silver, Côte-St-Luc Submitting a letter to the editor Letters should be sent by email to letters@montrealgazette.com We prioritize letters that respond to, or are inspired by, articles published by The Gazette. If you are responding to a specific article, let us know which one. Letters should be sent uniquely to us. The shorter they are — ideally, fewer than 200 words — the greater the chance of publication. Timing, clarity, factual accuracy and tone are all important, as is whether the writer has something new to add to the conversation. We reserve the right to edit and condense all letters. Care is taken to preserve the core of the writer’s argument. Our policy is not to publish anonymous letters, those with pseudonyms or “open letters” addressed to third parties. Letters are published with the author’s full name and city or neighbourhood/borough of residence. Include a phone number and address to help verify identity; these will not be published. We will not indicate to you whether your letter will be published. If it has not been published within 10 days or so, it is not likely to be. Please send the letter in the body of an email, not as an attachment.Police may search a vehicle based on the smell of raw cannabis, Illinois Supreme Court rules
ECB Poised for Further Interest Rate Cuts Amid Economic UncertaintyMan City crisis deepens with loss to Juventus in Champions League as Barcelona and Arsenal win Manchester City plunged deeper into trouble in the Champions League by losing 2-0 at Juventus in the latest setback in a scarcely believable run of poor results for the ailing English champions. City dropped to 22nd place in the 36-team standings and only the top 24 advances. Reaching the knockout stage looked a certainty before the season for a team that was European champion in 2022 and has won the last four Premier League titles. It's not anymore as City manager Pep Guardiola battles injuries and an apparent loss of belief among his players. Arsenal beat Monaco 3-0 and Barcelona won 3-2 at Borussia Dortmund. Rape allegation against Jay-Z won’t impact NFL's relationship with music mogul, Goodell says IRVING, Texas (AP) — NFL Commissioner Roger Goodell says a rape allegation against rapper Jay-Z won’t impact the NFL's relationship with the music mogul. Jay-Z's company Roc Nation has produced some of the NFL’s entertainment presentations including the Super Bowl halftime show. A woman who previously sued Sean “Diddy” Combs alleging she was raped at an awards show after-party in 2000 amended the lawsuit Sunday to include an allegation that Jay-Z was also at the party and participated in the sexual assault. Jay-Z says the rape allegation made against him is part of an extortion attempt. The NFL teamed up with Jay-Z’s Roc Nation in 2019 for events and social activism. The league and the entertainment company extended their partnership a few months ago. Juan Soto gets free luxury suite and up to 4 premium tickets for home games in $765M Mets deal DALLAS (AP) — Juan Soto gets free use of a luxury suite and up to four premium tickets behind home plate for regular-season and postseason New York Mets home games as part of his record $765 million, 15-year contract. The Mets agreed to provide personal team security for the All-Star outfielder and his family at the team’s expense for all spring training and regular-season home and road games, according to details of the agreement obtained by The Associated Press. New York agreed to assist Soto’s family for in-season travel arrangements, guaranteed he gets uniform No. 22 and included eight types of award bonuses. Ohio politician proposes make flag planting a felony after fight in Michigan rivalry game An Ohio politician has seen enough flag planting. Republican state Rep. Josh Williams said Wednesday on social media he's introducing a bill to make flag planting in sports a felony in the state. His proposal comes after the Nov. 30 fight at the Michigan-Ohio State rivalry football game when the Wolverines beat the Buckeyes 13-10 and then attempted to plant their flag at midfield. A fight ensued and police had to use pepper spray to disperse the players. Former Oklahoma quarterback Baker Mayfield famously planted a flag in the middle of the field at Ohio State after the Sooners beat the Buckeyes in 2017. FIFA confirms Saudi Arabia as 2034 World Cup host despite human rights concerns ZURICH (AP) — Saudi Arabia has been officially confirmed by FIFA as host of the 2034 World Cup in men’s soccer. The Saudi bid was the only candidate and was acclaimed by the applause of more than 200 FIFA member federations. They took part remotely in an online meeting hosted in Zurich on Wednesday by the soccer body’s president Gianni Infantino. The decision was combined with approving the only candidate to host the 2030 World Cup. Spain, Portugal and Morocco will co-host in a six-nation project, with Argentina, Paraguay and Uruguay each getting one of the 104 games. The South American connection will mark the centenary of Uruguay hosting the first World Cup in 1930. Jimmy Butler says he's not worrying about his future with Heat amid trade speculation Jimmy Butler knows there are tons of questions about his future with the Miami Heat. He might get traded, he might leave as a free agent next summer, he might exercise a $52.4 million option to return to the Heat or he might get a new contract. He isn't sure what will happen. The Heat forward spoke out about trade speculation Wednesday, telling reporters after practice that he doesn’t mind his name being in the rumor mill. US Biathlon officials ignored sexual harassment and abuse of female racers for decades, athletes say Sexual abuse and harassment by coaches and others who held positions of power over women on the U.S. Biathlon team were ignored or excused over decades by officials more concerned with winning medals than holding offenders accountable. That's according to Olympians and other biathletes interviewed by The Associated Press. While the men climbed the sport's ranks, these women say they were forced to end their careers early. The women and others describe a culture of misogyny and say they faced retaliation for speaking up. Three of the men denied allegations they were either part of the abuse or ignored allegations of abuse. A fourth did not respond to AP requests for comment. Tulane QB Mensah transfers to Duke; Mississippi State’s Van Buren, Cal’s Mendoza enter portal Former Tulane quarterback Darian Mensah has already found a new program in Duke, while Mississippi State’s Michael Van Buren Jr. and Cal’s Fernando Mendoza are exploring changes of their own in the transfer portal. Mensah is a redshirt freshman with three years of eligibility remaining. He told ESPN on Wednesday he has transferred to Duke. He attended the Blue Devils men’s basketball game against Incarnate Word on Tuesday night. The Blue Devils will face Mississippi in the Gator Bowl, but without 2024 starting quarterback Maalik Murphy and backup Grayson Loftis, who also entered the portal. All-Star left-hander Garrett Crochet acquired by Red Sox from White Sox for prospects DALLAS (AP) — All-Star left-hander Garrett Crochet has been acquired by the Boston Red Sox from the Chicago White Sox for four prospects. Catcher Kyle Teel, infielder Chase Meidroth, right-hander Wikelman Gonzalez and outfielder Braden Montgomery are headed to Chicago. The 25-year-old Crochet was 6-12 with a 3.58 ERA in 32 starts for a White Sox team that went 41-121. It's the most losses for any club since 1900. He was picked for the AL All-Star team in his first season as a starter. Selected 11th overall by Chicago in the 2020 amateur draft, Crochet made his big league debut that September. He had Tommy John surgery in April 2022. Lindsey Vonn savors chance to test out World Cup course as a forerunner in comeback bid at age 40 BEAVER CREEK, Colo. (AP) — Lindsey Vonn is trying to take her comeback step-by-step even if there’s plenty of reason to look down the road. For now, the 40-year-old American ski racer was concentrating on testing out the course as a forerunner. Soon, it will be her first World Cup race. Possibly later, the 2026 Winter Games at one of her favorite venues in Cortina d’Ampezzo, Italy. Vonn was one of three forerunners to test out the Birds of Prey course before the racers in the field went through a training run. Federica Brignone of Italy had the fastest time on a Birds of Prey course that’s new to quite a few racers.After recount, Newark council candidate ahead by just 4 votes
Ottawa Faces Winter Weather Warning with Snow Freezing Temperatures and Hazardous Travel Conditions Across Canada: New Travel Updates You Need To KnowElon Musk’s artificial intelligence startup xAI has secured $6 billion in fresh capital, capping off a funding round that values the company at over $40 billion. Bloomberg reports that in a major milestone, Elon Musk’s artificial intelligence venture xAI has raised an additional $6 billion from investors, according to a recent regulatory filing with the SEC. The successful completion of this funding round propels the startup’s valuation to more than $40 billion, cementing its position as one of the most valuable AI companies in the world. The new capital injection came from a diverse group of 97 investors, with individual stakes ranging from as little as $77,593 to much larger amounts. While the filing did not disclose the names of the investors or provide specifics on the company’s valuation and revenue, it underscores the growing interest and confidence in xAI’s potential to revolutionize the AI landscape. This latest funding round follows on the heels of xAI’s previous $6 billion raise in May 2024, which valued the company at $24 billion, inclusive of the funds raised. Many of xAI’s existing investors, such as Sequoia Capital and Andreessen Horowitz, are also backers of Musk’s other ventures, including X (formerly known as Twitter). Founded by Musk in 2023, xAI has been aggressively raising capital to fuel its ambitious projects. A significant portion of the funds has been directed towards the development of the company’s state-of-the-art supercomputer facility in Memphis, which opened earlier this year. Local officials have hailed the project as the “largest multibillion-dollar investment in the city of Memphis’s history,” and its growing presence is attracting other major technology companies to the area, including Nvidia, Dell, and Super Micro Computer. The centerpiece of xAI’s offerings is its cutting-edge chatbot, Grok, which is currently accessible to paying users of X. Grok’s advanced capabilities and seamless integration with X have garnered significant attention from users and industry experts alike. As xAI continues to expand its operations and refine its AI technologies, the company is poised to play a pivotal role in shaping the future of artificial intelligence. With Musk’s track record of disrupting industries and pushing the boundaries of innovation, investors are betting big on xAI’s potential to transform the way we interact with and leverage AI in our daily lives. The successful completion of this funding round not only provides xAI with the resources to accelerate its research and development efforts but also solidifies its position as a major player in the highly competitive AI market. Read more at Bloomberg here. Lucas Nolan is a reporter for Breitbart News covering issues of free speech and online censorship.
T-cell malignancies account for about 10-15% of all lymphoid malignancies, and their treatment often involves chemotherapy, immunotherapy, or stem cell transplantation. These cancers can be particularly challenging due to their heterogeneity and resistance to traditional treatments. LAS VEGAS , Dec. 11, 2024 /PRNewswire/ -- T-cell malignancies are a group of cancers originating from the T-cells, a vital part of the immune system responsible for recognizing and combating foreign invaders. These cancers can develop when T-cells undergo genetic mutations, leading to uncontrolled growth and division. T-cell malignancies are generally categorized into two broad types: T-cell lymphomas and T-cell leukemias. T-cell lymphomas primarily affect the lymphatic system, involving lymph nodes and other lymphoid tissues, while T-cell leukemias impact the blood and bone marrow. These malignancies are often more aggressive and harder to treat than B-cell cancers due to their complex biology and resistance to conventional therapies. Symptoms can vary but typically include enlarged lymph nodes, fever, night sweats, and weight loss. Treatment options include chemotherapy, radiation therapy, and novel therapies like CAR T-cell therapy and targeted therapies, which are advancing the understanding and management of these challenging cancers. DelveInsight has recently released a series of epidemiology-based market reports focusing on T-cell malignancies including Acute Lymphoblastic Leukemia, Peripheral T-cell Lymphoma, Cutaneous T-cell Lymphoma, Anaplastic Large Cell Lymphoma, and Adult T-cell Leukemia/Lymphoma . These reports include a comprehensive understanding of current treatment practices, historical and forecasted patient pool, emerging drugs, market share of individual therapies, and historical and forecasted market size from 2020 to 2034 segmented into 7MM [ the United States , the EU-4 ( Italy , Spain , France , and Germany ), the United Kingdom , and Japan ]. Additionally, the reports feature exhaustive analysis of prominent companies working with their emerging candidates in different stages of clinical development. Let's deep dive into the assessment of these T-cell malignancies markets individually. Acute Lymphocytic Leukemia Market Acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, is a cancer that develops in the blood and bone marrow. It originates from immature white blood cells known as lymphocytes in the bone marrow and is marked by the excessive production of immature cells, referred to as lymphoblasts or leukemic blasts. As the bone marrow fails to produce sufficient red blood cells, healthy white blood cells, and platelets, individuals with ALL are more prone to anemia, frequent infections, and easy bruising or bleeding. Among the 7MM, the US accounted for the highest number of incident cases of acute lymphocytic leukemia. The total incident cases of acute lymphocytic leukemia in the US comprised approximately 6,800 cases in 2023 and are projected to increase during the forecast period. Among the type-specific cases of acute lymphocytic leukemia, B-acute lymphocytic leukemia accounted for nearly 85% of the cases, while T-acute lymphocytic leukemia accounted for nearly 15% in the US. The treatment paradigms of acute lymphocytic leukemia have been revolutionized with the advent of tyrosine kinase inhibitors targeting BCR-ABL1 (GLEEVEC [imatinib mesylate], SPRYCEL [dasatinib], and ICLUSIG [ponatinib]), monoclonal antibodies targeting CD20 (RITUXAN), antibody-drug conjugates targeting CD22 (BESPONSA), bispecific antibodies (BLINCYTO), CD19 chimeric antigen receptor T cell therapy (KYMRIAH and TECARTUS) , and others. As per DelveInsight analysis, in 2023, the market size for acute lymphocytic leukemia across the 7MM was around USD 1.6 billion , with projections indicating further growth by 2034. The United States dominated the market in 2023, contributing approximately USD 1.2 billion . ALL presents a significant market opportunity, with BLINCYTO currently leading the segment. Amgen continues to drive innovation in ALL through its BiTE Technology, receiving FDA approval in June 2024 . Additionally, Amgen is advancing a registration-enabling study to develop a subcutaneous injection formulation of blinatumomab. Acute Lymphocytic Leukemia Pipeline Therapies and Companies Orca-T: Orca Biosystems AUTO1/22: Autolus Therapeutics VENCLEXTA/VENCLYXTO (venetoclax): AbbVie and Roche (Genentech) Daratumumab: J&J Innovative Medicine IMBRUVICA (ibrutinib): Pharmacyclics (an AbbVie Company) JAKAFI (ruxolitinib): Incyte Corporation/Novartis VYXEOS (CPX-351): Jazz Pharmaceuticals Obecabtagene autoleucel (obe-cel): Autolus Therapeutics SNDX-5613 (revumenib): Syndax Pharmaceuticals UCART22: Cellectis ADCT-602: ADC Therapeutics WU-CART-007: Wugen For a comprehensive view of the acute lymphocytic leukemia market, check out the Acute Lymphocytic Leukemia Market Assessment Peripheral T-cell Lymphoma Market Peripheral T-cell lymphoma represents a heterogeneous collection of aggressive lymphomas arising from mature T-cells and natural killer cells, comprising approximately 10–15% of all non-Hodgkin lymphomas globally. PTCL is more prevalent in Asia compared to North America and Europe . PTCL has been reported to account for 25% of all NHL cases in Japan . The increased rate of T-cell lymphomas in Asia is attributed to the low incidence of follicular lymphomas. The total incident cases of PTCL in the 7MM were 26,000 cases in 2023; these cases are estimated to increase by 2034. As more targetable mutations are identified and new targeted therapies are developed, the range of treatment options for patients and oncologists continues to expand. However, with the rapid pace of drug approvals, it is crucial to ensure that adequate supporting data justifies the use of specific therapies in the appropriate treatment settings, whether as adjuvant, consolidation, first-line, or subsequent treatments. Peripheral T-cell lymphoma remains a significant therapeutic challenge due to its aggressive nature, rarity, and high heterogeneity. Conventional chemotherapy for PTCL typically involves anthracycline-based regimens (such as CHOP and EPOCH) or non-anthracycline alternatives (including platinum, etoposide, gemcitabine, and methylprednisolone). While the majority of patients initially undergo chemotherapy, nearly a quarter develop primary refractory disease. Many others relapse even after responding to induction chemotherapy, with a median overall survival of just six months. According to NCCN guidelines, specific PTCL subtypes are also treated with six cycles of CHOP-21 or CHOEP, often combined with involved-site radiation therapy. The FDA has approved several drugs for PTCL treatment, including BELEODAQ (Belinostat, Acrotech Biopharma), ISTODAX (Romidepsin, Celgene), FOLOTYN (Pralatrexate, Acrotech Biopharma), ARRANON (Nelarabine, GlaxoSmithKline), XALKORI (Crizotinib, Pfizer), and ADCETRIS (Brentuximab Vedotin, Seattle Genetics). Until recently, there was no established standard of care for first-line treatment in PTCL, leaving a significant gap in approved therapies. The approval of ADCETRIS in November 2018 by the US FDA has transformed the treatment landscape. ADCETRIS, in combination with chemotherapy, is now the first and only FDA-approved regimen for first-line treatment of adults with previously untreated systemic ALCL or other CD30-expressing PTCL. Notably, its approval came less than two weeks after submission under the FDA's real-time oncology review pilot program. Key players, such as Secura Bio, HUYA Bioscience International, Verastem, Solasia Pharma, Seagen, Dizal Pharmaceutical , and others, are evaluating their lead candidates in different stages of clinical development, respectively. As per the DelveInsight assessment, the total market size in the 7MM for PTCL was estimated to be ~USD 680 million in 2020, which is projected to show positive growth by 2034. This growth of the PTCL market is expected to be mainly driven by increased diagnosed incidence, patient awareness, and a robust clinical pipeline during the forecast period (2024–2034). PTCL Pipeline Therapies and Companies COPIKTRA (duvelisib): Secura Bio Linperlisib (YY-20394): Shanghai YingLi Pharmaceutical Golidocitinib (DZD4205) : Dizal Pharmaceuticals Nanatinostat + Valganciclovir: Viracta Therapeutics Lacutamab/IPH4102: Innate Pharma Sugemalimab (CS1001): CStone Pharmaceuticals AFM13: Affimed Tolinapant (ASTX660): Otsuka Pharmaceutical/Astex Pharmaceuticals AUTO4: Autolus MT-101: Myeloid Therapeutics KEYTRUDA (pembrolizumab): Merck Sharp & Dohme OPDIVO (nivolumab): Bristol Myers Squibb To gain a deeper understanding of the PTCL market, be sure to explore the Peripheral T-cell Lymphoma Market Outlook Cutaneous T-cell Lymphoma Market Cutaneous T-cell lymphomas are rare cancers that predominantly involve the skin. Some types progress slowly within the skin, while others may spread to the blood or lymph nodes. The most prevalent form of CTCL is mycosis fungoides, along with its leukemic variant, Sézary syndrome. Another frequently encountered group includes CD30-positive lymphoproliferative disorders (CD30+ LPDs). In 7MM, the United States accounted for the highest number of incident cases of CTCL, which is 46% of the total incident population of CTCL in 7MM in 2023, as per DelveInsight. In the US, out of all stage-specific cases of CTCL, Stage-IA accounted for the highest number of cases, followed by Stage-IB and Stage-IIB cases in 2023. There is currently no approved first-line therapy for early-stage (I–IIA) cutaneous T-cell lymphoma, highlighting a significant unmet need in this patient population. Treatment decisions for patients with mycosis fungoides and Sézary syndrome, both types of CTCL, are influenced by factors such as the extent of skin involvement, the type of lesions, and whether metastasis is present. Therapies for mycosis fungoides focus on either localized skin treatment or systemic approaches, allowing many patients to achieve long-term remission and maintain normal lives. In contrast, Sézary syndrome, marked by systemic involvement, often requires systemic therapies, either alone or in combination, to improve long-term outcomes. TARGRETIN, ADCETRIS, POTELIGEO, ZOLINZA, and ISTODAX are approved by the US FDA for the treatment of Mycosis Fungoides and Sezary Syndrome. Other systemic therapies such as interferons (alfa and gamma), methotrexate, and other retinoids (acitretin and isotretinoin) also offer clinical benefits but have only been evaluated in small studies. As per DelveInsight analysis, the market size of CTCL in the 7MM is expected to cross USD 780 million by 2034. This growth is mainly driven by advancements in targeted therapies, rising awareness of rare cancers, and increasing research and development investments. The adoption of innovative treatments such as monoclonal antibodies and checkpoint inhibitors, coupled with improved diagnostic technologies, is anticipated to enhance market expansion. Additionally, a growing patient population and supportive regulatory policies will further bolster market growth. CTCL Pipeline Therapies and Companies HyBryte (SGX301): Soligenix KINSELBY (resminostat): 4SC AG Lacutamab: Innate Pharma Explore in-depth for a comprehensive understanding of the Cutaneous T-cell Lymphoma Clinical Trials Anaplastic Large Cell Lymphoma Market Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin lymphoma, characterized by large, irregular lymphoid cells that express the CD30 antigen. ALCL accounts for approximately 1% of all NHL cases and 16% of T-cell lymphomas. ALK-positive ALCL is associated with conditions such as HIV, mycosis fungoides, and pulmonary or inflammatory pseudotumors. In contrast, ALK-negative ALCL is more commonly observed in older individuals and is frequently linked to extranodal disease involvement. As per DelveInsight's analysis, ALCL has a slightly higher incidence in men compared to women. ALK-positive ALCL typically affects children and adolescents, with a median age of 30 years, while ALK-negative ALCL tends to affect older adults, with a median age of 54 years. ALK-positive ALCL carries a better prognosis, with 5-year survival rates of 70% to 90% , compared to 40% to 60% for ALK-negative ALCL. The treatment of ALCL varies based on its subtype and stage. Systemic ALCL is commonly addressed with chemotherapy regimens such as CHOP or CHOEP, showing improved outcomes in ALK-positive cases. The key drugs used for the treatment of anaplastic large cell lymphoma are – Pfizer's XALKORI and Takeda's ADCETRIS. For relapsed or refractory cases, brentuximab vedotin has proven effective. Primary cutaneous ALCL is typically managed through radiation, surgery, or chemotherapy and generally has a good prognosis. Breast implant-associated ALCL is treated by removing the implant, with radiation or chemotherapy added if the disease has spread. The ALCL market is anticipated to witness a substantial positive shift owing to better uptake of existing drugs, the expected market launch of therapies, and raised awareness. Additionally, the ALCL market size is expected to increase due to an increasing diagnosed prevalent population, awareness about the subtype of ALCL (Breast implant-associated ALCL), and an increase in R&D activity, which would essentially boost the commercial success of emerging therapies. Anaplastic Large Cell Lymphoma Pipeline Therapies and Companies AUTO4: Autolus Therapeutics SGN-35T: Seagen To access a complete analysis of the anaplastic large cell lymphoma market, visit Anaplastic Large Cell Lymphoma Market Assessment Adult T-cell Leukemia/Lymphoma Market Adult T-cell Leukemia/Lymphoma (ATLL) is a rare and aggressive malignancy of mature T lymphocytes caused by infection with the human T-cell lymphotropic virus type 1 (HTLV-1). ATLL is classified into four clinical subtypes: acute, lymphomatous, chronic, and smoldering, each with distinct prognoses. The acute and lymphomatous forms are the most aggressive, with a median survival of less than a year without treatment. ATLL commonly affects adults aged 40–60 years and is associated with immunosuppression, hypercalcemia, and frequent involvement of skin, lymph nodes, and bone marrow. The global prevalence varies, but it is estimated that about 5–10% of individuals infected with HTLV-1 develop ATLL after decades of latency. Treatment for ATLL is challenging, as the disease presents with a wide range of clinical manifestations, from chronic to acute forms. First-line therapy often involves combination chemotherapy regimens, such as the CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone) regimen, which has shown effectiveness in treating the aggressive forms of ATLL. For more refractory or relapsed cases, a bone marrow transplant may be considered as a curative option. Additionally, the use of denileukin diftitox, a fusion protein targeting CD25, has been approved for relapsed or refractory ATLL. Newer therapies are exploring the use of targeted agents, including histone deacetylase inhibitors (e.g., romidepsin) and lenalidomide, a potent immune-modulatory drug, to improve outcomes in patients with advanced disease. However, despite these options, ATLL treatment remains an area in urgent need of innovation to improve survival rates and quality of life for patients. The Adult T-cell leukemia/lymphoma market is expected to witness significant growth in the coming years, driven by advancements in diagnostics, therapies, and an increased understanding of the disease. Additionally, innovations in immunotherapies, including monoclonal antibodies, CAR-T cell therapies, and combination regimens, are expected to revolutionize the treatment landscape, offering hope for improved survival rates. Moreover, ongoing research into biomarkers and precision medicine will likely lead to better patient stratification and more effective treatment plans. Overall, the ATLL market is poised for expansion, attracting investments in research and development, clinical trials, and regulatory approvals to meet the growing need for better, more accessible therapies. Adult T-cell Leukemia/Lymphoma Pipeline Therapies and Companies Valemetostat Tosylate: Daiichi Sankyo BEAM-201: Beam Therapeutics Inc. Tolinapant: Astex Pharmaceuticals To delve into the adult T-cell leukemia/lymphoma market landscape in more detail, access the Adult T-cell Leukemia/Lymphoma Market Report Trending Oncology Reports Non-Hodgkin Lymphoma Market Non-Hodgkin Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key Non-Hodgkin lymphoma companies, including Roche, Pfizer, Amgen, Novartis, Teva Pharmaceuticals, Genentech, ACD Therapeutics , among others. Non-Hodgkin Lymphoma Pipeline Non-Hodgkin Lymphoma Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, including clinical and non-clinical stage products, and the key Non-Hodgkin lymphoma companies, including Roche, Pfizer, Amgen, Novartis, Teva Pharmaceuticals, Genentech, ACD Therapeutics , among others. B-Cell Lymphoma Market B-Cell Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key B-cell lymphoma companies, including Vincerx Pharma, Ubix Therapeutics, Biomea Fusion Inc, Shanghai Hengrui Pharmaceutical, BeiGene, Hanmi Pharmaceutical, among others. Diffuse Large B-Cell Lymphoma Market Diffuse Large B-Cell Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key B-cell lymphoma companies, including AbbVie, Genmab, Merck, Roche, Xencor and Janssen, Denovo Biopharma, Calithera Biosciences, IMV, Biogen, Autolus Therapeutics, Allogene Therapeutics, Novartis, Miltenyi Biomedicine, Regeneron Pharmaceuticals, among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Contact Us Shruti Thakur info@delveinsight.com +14699457679 www.delveinsight.com Logo: https://mma.prnewswire.com/media/1082265/DelveInsight_Logo.jpgSouth Korean star Park Sung-hoon talks K-dramas at Red Sea International Film Festival
FORT LAUDERDALE, Fla. — Gov. Ron DeSantis announced a quick special election timetable Friday for voters to replace former U.S. Rep. Matt Gaetz in a Republican congressional seat in Florida’s Panhandle. His urgency is a marked contrast to his monthslong delay setting a special election to fill a vacancy in a Democratic district in South Florida. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.
ORCHARD PARK, N.Y. (WKBW) — For the first time this season, snow is in the forecast for much of Western New York, with the potential for a "significant" lake effect event later this week and the weekend. Of immediate interest is the potential impact on post-Thanksgiving travel and the Sunday Night Football game in Orchard Park between the Buffalo Bills and San Francisco 49ers. It's a situation the Orchard Park Highway Department is monitoring closely. "We've been watching it now for about a week," said Andy Slotman, Highway Superintendent for the Town of Orchard Park. "We're anticipating winter weather coming in for the end of the holiday and the Bills game Sunday." During any snow event, Slotman told me that the Town of Orchard Park works with state and county partners to keep roads clear near and around Highmark Stadium. He said he will meet with his emergency management team and employees this week to discuss addressing any potential snow surrounding the game as the forecast becomes clearer. "It may be the first of this season, but it's not the first that we've ever dealt with," said Slotman. "The challenging part is obviously when it snows and what rates and whether or not we can have everything cleared." The Town of Orchard Park has 11 large snow plows, three loaders with snow removal equipment, and a team of around 40 employees. "Obviously we will have a lot of visitors that come into our community. We will be here probably on standby to make sure they can all get home safely if the weather does come in as predicted," said Slotman. "We're ready."Emilia Clarke, celebrated for her cheerful and bubbly personality, cherished her experience while filming HBO’s hit period drama Game of Thrones. Known for her portrayal of Daenerys Targaryen, the iconic “Mother of Dragons,” Clarke worked alongside a diverse cast of actors, including those playing her character’s many male counterparts. When Emilia Clarke Shot A Violent Sex Scene In the show’s first season, the frequent and often intense intimate scenes drew significant attention, particularly those between Daenerys and Khal Drogo, played by Jason Momoa. While their on-screen interactions were sometimes unsettling, including a violent encounter early in their forced marriage, the atmosphere behind the scenes was strikingly different. Recalling one memorable moment, Clarke shared how a particular scene required comic relief due to its heavy emotional weight. During the filming of a controversial scene, Momoa lightened the mood by using an unconventional prop—a pink, fluffy sock—for modesty. “So, obviously, there’s nudity, and you try to lighten the mood,” Clarke explained. “Not only was it a s*x scene, but a violent one at that. Instead of a modesty sock, Jason used a big, pink, fluffy sock.” Clarke admitted she couldn’t hold back her laughter, causing temporary delays in filming. “It’s huge and pink, and I didn’t know what to do,” she said during a humorous appearance on The Graham Norton Show. The clip has since gained viral attention online. Emilia Clarke’s Struggles During GoT While Clarke enjoyed many moments on set, she also faced challenges during the long-running series. The actress revealed that filming Game of Thrones left her feeling lost at times. Her struggles extended beyond the professional sphere, as she endured two life-threatening aneurysms and the devastating loss of her father during the show’s production. Despite these hardships, Clarke’s resilience and humor became hallmarks of her experience on the series, endearing her to fans both on and off the screen. MUST READ: Is Barry Keoghan In Trouble After Posting Thirst Traps Pics On Social Media? Actor DELETES Instagram Amid Split With Sabrina CarpenterC3.ai ( AI 8.25% ) stock is soaring in Thursday's trading. The company's share price was up 9.7% as of 2:30 p.m. ET. Meanwhile, the S&P 500 index was up roughly 0.5%. C3.ai stock is seeing big gains on the heels of Nvidia 's third-quarter report yesterday. Nvidia is the leading provider of the graphics processing units (GPUs) that are powering the artificial intelligence ( AI ) revolution, and its performance is often viewed as a bellwether for the broader AI industry. Nvidia's Q3 report is lifting C3.ai stock After the market closed yesterday, Nvidia published results for the third quarter of its 2025 fiscal year, which ended Oct. 29. The AI leader posted sales and earnings performance for the quarter that beat Wall Street's expectations, and it also issued forward guidance that came in better than anticipated. Nvidia posted non-GAAP (adjusted) earnings per share of $0.81 on sales of $35.08 billion, topping the average analyst estimate's call for adjusted earnings of $0.75 on sales of $33.16 billion. The company's revenue was up 94% year over year, and adjusted earnings per share were up 103%. Meanwhile, the average analyst estimate had called for the business to report adjusted earnings per share of $0.75 on revenue of $33.16 billion. Nvidia expects revenue of roughly $37.5 billion for the current quarter. If the business were to hit that target, it would mean delivering annual sales growth of roughly 70%. While the company's sales growth is decelerating, the overall demand outlook for the AI space is very strong. That bodes well for C3.ai and other players, and investors are responding by bidding up the company's stock today. What's next for C3.ai? With its last quarterly report, C3.ai's revenue increased 21% year over year to $87.2 million. Meanwhile the business posted an adjusted loss per share of $0.05. Sales growth actually looks poised to accelerate in the near term. For the current quarter, the company is guiding for sales to come in between $88.6 million and $93.6 million -- good for growth of roughly 24.5% at the midpoint. Meanwhile, full-year sales are projected to come in between $370 million and $395 million. If the business were to hit the midpoint of that guidance range, it would mean delivering sales growth of approximately 23%. Along with some encouraging forward sales guidance, C3.ai has also been scoring some promising partnerships recently. The company recently announced that it's forged a new partnership with Microsoft to accelerate the adoption of enterprise AI applications, and it published a press release yesterday detailing a partnership with Capgemini targeting AI solutions for industries including life sciences, energy, utilities, government, banking, and manufacturing.Alan Jones’ touching story
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