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Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. Recommended Videos For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.Kolkata: Trinamool Congress has witnessed an average 14 per cent positive vote swing in its favour in the bypolls. The maximum positive swing in vote share in favour of the ruling party at Sitai in Cooch Behar district is at 26.66 per cent. In Sitai, Trinamool Congress candidate Sangita Roy won by a massive margin of 1,30,156 votes, defeating her nearest rival, BJP’s Dipak Kumar Roy. Roy’s winning margin far surpassed that of the victory margin of her husband and the erstwhile Trinamool legislator, Jagadish Chandra Barma Basunia, in the 2021 Assembly elections who had won by just 10,112 votes. In the bypolls Roy secured 76.08 per cent of the total votes polled up again from 49.92 per cent secured by her husband in 2021. The second highest positive vote swing in favour of Trinamool Congress in the latest bypolls was from Haroa in North 24 Parganas district at 19.29 per cent over what it was in the 2021 state assembly polls. Trinamool candidate Seikh Rabiul Islam won by the biggest margin in this round of bypolls, defeating his closest contestant and Left Front-supported All India Secular Front (AISF) candidate Piyarul Islam by a margin of 1,31,388 votes. In 2021 Rabiul’s father Haji Nurul Islam got elected by a margin of 80,978 votes. In the bypolls Rabiul secured 76.63 per cent of the total votes polled up again from 57.34 per cent secured by his father in 2021. The third highest positive vote swing for Trinamool Congress in the bypolls is from Madarihat in Alipurduar district at 17.49 per cent. There the ruling party candidate Jayprakash Toppo defeated his nearby BJP candidate Rahul Lohar by a margin of 28,168 votes, In the 2021 assembly elections, the erstwhile BJP candidate Maoj Tigga got elected by a margin of 29,685 votes defeating Trinamool Congress’s Rajesh Lakra. Tigga was elected from Madarihat in the two successive Assembly elections in 2016 and 2021. In fact, this is the first-ever victory of Trinamool Congress from Madarihat. In the bypolls Toppo secured 54.05 per cent of the total votes polled up again from 36.56 per cent by Lakra in 2021. In the Naihati assembly constituency in North 24 Parganas district where Trinamool Congress witnessed a positive vote swing by 12 per cent from what it was in the 2021 state Assembly polls. In the bypolls, Trinamool candidate Sanat Dey won from the Naihati Assembly constituency in North 24 Parganas district, defeating his nearest contest Rupak Mitra of the BJP, by a margin of 49,277 votes up from the winning margin of erstwhile party candidate Partha Bhowmik of 18,885 in 2021. In the bypolls, Dey’s share of total votes polled stands at 62.97 per cent up against Bhowmik’s 50 per cent in 2021. In the Bankura district, where the positive vote swing in favour of Trinamool Congress had been comparatively lower at 5.98 per cent. Trinamool candidate Falguni Singhababu won by a margin of 33,856 votes over his nearest contestant and BJP candidate Ananya Roy Chakraborty, up from the victor margin of 34,082 of the erstwhile party legislator Arup Chakraborty in 2021. In the bypolls, Singhababu’s share of total votes polled stands at 62.07 per cent up again from Chakraborty’s share of 46.1 per cent in 2021. In the Medinipur Assembly constituency in West Midnapore district where the positive vote swing in favour of the ruling party in the bypolls had been just 2.72 per cent. Trinamool candidate Sujoy Hazra defeated his nearest contestant and BJP candidate Subhajit Roy by a margin of 33,996 vote up from the erstwhile party legislator June Malia’s victory margin of 24,397 votes. In the bypolls, Hazra’s share of total votes polled stands at 53.44 per cent up again from Malia’s share of 50.72 per cent in 2021.
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The overthrow of the Assad regime in Syria risks creating a haven for terrorists that could lead to a new form of Islamic State, the UK’s terror watchdog has warned. Jonathan Hall KC, the independent reviewer of terrorism legislation, said he was “as worried as I was with Libya, Iraq and Afghanistan” after the fast-moving developments that resulted in the rebel group Hayat Tahrir al-Sham (HTS) seizing the capital, Damascus. He said he feared that the developments could lead to the release from prisons and detention camps in northeast Syria of jihadist fighters who could “form the kernel of a new Islamic State” or “rush to join HTS and firm up their extremist objectives ”. Sir Keir Starmer said the UK welcomed the fall ofPunjab by-elections: AAP wins 3 out of 4 assembly seats, Cong 1