COPENHAGEN, Denmark, Dec. 12, 2024 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S (Nasdaq: ASND) today announced that the U.S. Food & Drug Administration (FDA) has accepted for review its supplemental Biologics License Application (sBLA) in adult growth hormone deficiency (GHD) for TransCon hGH (lonapegsomatropin-tcgd; marketed as SKYTROFA® for pediatric GHD). The FDA set a Prescription Drug User Fee Act (PDUFA) goal date of July 27, 2025. “This marks another step towards achieving our objective to expand SKYTROFA’s label beyond pediatric GHD and expand its reach to address new groups of patients,” said Jan Mikkelsen, Ascendis Pharma’s President and Chief Executive Officer. “Adult GHD is an undertreated condition associated with significant comorbidities and higher annual healthcare costs compared to the 5-10% of patients who receive treatment, indicative of the high unmet need.” The sBLA submission is based on results from foresiGHt, a Phase 3 randomized, parallel-arm, placebo-controlled (double-blind) and active-controlled (open-label) trial that compared the efficacy and safety of weekly TransCon hGH with weekly placebo and daily human growth hormone (hGH) in adults with GHD. The trial evaluated 259 adults with GHD aged 23 to 80 years old, randomized 1:1:1, titrated to receive a target fixed dose of TransCon hGH, placebo, or daily hGH based on age and oral estrogen intake with approximately equivalent hGH mg/week for TransCon hGH and daily hGH. TransCon hGH demonstrated superiority on its primary efficacy and key secondary efficacy endpoints at Week 38, with TransCon hGH-treated participants showing a statistically significant reduction from baseline in trunk fat and increase in total body lean mass at Week 38 compared to placebo. In the trial, TransCon hGH was generally safe and well tolerated, with no discontinuations related to study drug and with comparable safety and tolerability to daily hGH treatment. About Adult Growth Hormone Deficiency Growth hormone plays an essential role in the health of children and adults, promoting normal growth in children and maintenance of normal body composition and cardiometabolic health throughout adulthood. In adults, growth hormone boosts protein production, promotes fat utilization, enhances muscle mass, and helps regulate blood sugar levels. Adult GHD is a condition in which an individual’s body does not produce enough growth hormone. Symptoms and morbidity can include central obesity, metabolic syndrome, decreased bone density, alterations in lipid profile and markers of cardiovascular risk, fatigue, general weakness, lack of muscle tone, and psychological symptoms such as cognitive impairment, social isolation, lack of motivation, and depression.1 About Ascendis Pharma A/S Ascendis Pharma is applying its innovative TransCon technology platform to build a leading, fully integrated biopharma company focused on making a meaningful difference in patients’ lives. Guided by its core values of Patients, Science, and Passion, Ascendis uses its TransCon technologies to create new and potentially best-in-class therapies. Ascendis is headquartered in Copenhagen, Denmark and has additional facilities in Europe and the United States. Please visit ascendispharma.com to learn more. Forward-Looking Statements This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this press release regarding Ascendis’ future operations, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to (i) the PDUFA goal date for SKYTROFA, (ii) Ascendis’ objective to expand SKYTROFA’s label and reach to address new groups of patients, (iii) Ascendis’ ability to apply its TransCon technology platform to build a leading, fully integrated biopharma company, and (iv) Ascendis’ use of its TransCon technologies to create new and potentially best-in-class therapies. Ascendis may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations, and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that Ascendis makes, including the following: dependence on third party manufacturers, distributors and service providers for Ascendis’ products and product candidates; unforeseen safety or efficacy results in Ascendis’ development programs or on-market products; unforeseen expenses related to commercialization of any approved Ascendis products; unforeseen expenses related to Ascendis’ development programs; unforeseen selling, general and administrative expenses, other research and development expenses and Ascendis’ business generally; delays in the development of its programs related to manufacturing, regulatory requirements, speed of patient recruitment or other unforeseen delays; Ascendis’ ability to obtain additional funding, if needed, to support its business activities; the impact of international economic, political, legal, compliance, social and business factors. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Ascendis’ business in general, see Ascendis’ prospectus supplement filed on September 20, 2024 and Ascendis’ current and future reports filed with, or submitted to, the U.S. Securities and Exchange Commission (SEC), including its Annual Report on Form 20-F filed with the SEC on February 7, 2024. Forward-looking statements do not reflect the potential impact of any future licensing, collaborations, acquisitions, mergers, dispositions, joint ventures, or investments that Ascendis may enter into or make. Ascendis does not assume any obligation to update any forward-looking statements, except as required by law. Ascendis, Ascendis Pharma, the Ascendis Pharma logo, the company logo, TransCon, and SKYTROFA ® , are trademarks owned by the Ascendis Pharma group. © December 2024 Ascendis Pharma A/S. 1.Hoffman AR, Mathison T, Andrews D, Murray K, Kelepouris N, Fleseriu M. Adult Growth Hormone Deficiency: Diagnostic and Treatment Journeys From the Patients' Perspective. J Endocr Soc. 2022;6(7):bvac077. Published 2022 May 12. doi:10.1210/jendso/bvac077
Stock market today: Asian shares are mostly lower, with most world markets closed for Christmas BANGKOK (AP) — Shares are lower in Tokyo and Shanghai, two of only a handful of world markets open on Christmas day. Oil prices rose. On Tuesday, stocks closed higher on Wall Street in a shortened holiday session. Gains in Big Tech stocks helped the S&P 500 to a 1.1% gain, while the Dow Jones Industrial Average rose 0.9%. The Nasdaq composite climbed 1.3%. American Airlines shook off an early loss and ended mostly higher after the airline briefly grounded flights nationwide due to a technical issue. Treasury yields held steady. The yield on the 10-year Treasury was little changed at 4.59% Japan to maximize nuclear power in clean-energy push as electricity demand grows TOKYO (AP) — A Japanese government panel has largely supported a draft energy policy calling for bolstering renewables up to half of Japanese electricity needs by 2040. It also recommends maximizing the use of nuclear power to accommodate the growing demand for power in the era of AI while meeting decarbonization targets. Cabinet is expected to formally approve the plan by March following a period of public consultation. The policy says nuclear energy should account for 20% of Japan’s energy supply in 2040, with renewables expanded to 40-50% and coal-fired power reduced to 30-40%. Biden will decide on US Steel acquisition after influential panel fails to reach consensus WASHINGTON (AP) — A powerful government panel has failed to reach consensus on the possible national security risks of a nearly $15 billion proposed deal for Nippon Steel of Japan to purchase U.S. Steel. The Committee on Foreign Investment in the United States on Monday sent its long-awaited report to President Joe Biden, a longtime opponent of the deal. Some federal agencies represented on the panel were skeptical that allowing a Japanese company to buy an American-owned steelmaker would create national security risks. That's according to a U.S. official familiar with the matter. Both Biden and President-elect Donald Trump opposed the merger and vowed to block it. Nippon Steel says it is confident the deal will go ahead. Nissan and Honda to attempt a merger that would create the world's No. 3 automaker TOKYO (AP) — Japanese automakers Nissan and Honda have announced plans to work toward a merger that would catapult them to a top position in an industry in the midst of tectonic shifts as it transitions away from its reliance on fossil fuels. The two companies said they signed an agreement on integrating their businesses on Monday. Smaller Nissan alliance member Mitsubishi Motors agreed to join the talks. News of a possible merger surfaced earlier this month. Japanese automakers face a strong challenge from their Chinese rivals and Tesla as they make inroads into markets at home and abroad. What a merger between Nissan and Honda means for the automakers and the industry BANGKOK (AP) — Japanese automakers Honda and Nissan will attempt to merge and create the world’s third-largest automaker by sales as the industry undergoes dramatic changes in its transition away from fossil fuels. The two companies said they had signed a memorandum of understanding on Monday and that smaller Nissan alliance member Mitsubishi Motors also had agreed to join the talks on integrating their businesses. Honda will initially lead the new management, retaining the principles and brands of each company. Following is a quick look at what a combined Honda and Nissan would mean for the companies, and for the auto industry. Survey: Small businesses are feeling more optimistic about the economy after the election A survey shows small business owners are feeling more optimistic about the economy following the election. The National Federation of Independent Businesses’ Small Business Optimism Index rose by eight points in November to 101.7, its highest reading since June 2021. The Uncertainty Index declined 12 points in November to 98, following October’s pre-election record high of 110. NFIB Chief Economist Bill Dunkelberg said small business owners became more certain about future business conditions following the presidential election, breaking a nearly three-year streak of record high uncertainty. The survey also showed that more owners are also hoping 2025 will be a good time to grow. Heavy travel day starts with brief grounding of all American Airlines flights WASHINGTON (AP) — American Airlines briefly grounded flights nationwide due to a technical problem just as the Christmas travel season kicked into overdrive and winter weather threatened more potential problems for those planning to fly or drive. Government regulators cleared American flights to get airborne Tuesday about an hour after the Federal Aviation Administration ordered a national ground stop, which prevented planes from taking off. American said in an email that the problem was caused by vendor technology in its flight operating system. Aviation analytics company Cirium said flights were delayed across American’s major hubs, with only 37% leaving on time. Nineteen flights were cancelled. Nordstrom to be acquired by Nordstrom family and a Mexican retail group in $6.25 billion deal Century-old department store Nordstrom has agreed to be acquired and taken private by Nordstrom family members and a Mexican retail group in a $6.25 billion deal. Nordstrom shareholders will receive $24.25 in cash for each share of Nordstrom common stock, representing a 42% premium on the company’s stock as of March 18. Nordstrom’s board of directors unanimously approved the the proposed transaction, while Erik and Pete Nordstrom — part of the Nordstrom family taking over the company — recused themselves from voting. Following the close of the transaction, the Nordstrom Family will have a majority ownership stake in the company. Stock market today: Wall Street rallies ahead of Christmas Stocks closed higher on Wall Street ahead of the Christmas holiday, led by gains in Big Tech stocks. The S&P 500 added 1.1% Tuesday. Trading closed early ahead of the holiday. Tech companies including Apple, Amazon and chip company Broadcom helped pull the market higher. The Dow Jones Industrial Average rose 0.9%, and the Nasdaq composite climbed 1.3%. American Airlines shook off an early loss and ended mostly higher after the airline briefly grounded flights nationwide due to a technical issue. Treasury yields held steady in the bond market. The yield on the 10-year Treasury was little changed at 4.59% An analyst looks ahead to how the US economy might fare under Trump WASHINGTON (AP) — President-elect Donald Trump won a return to the White House in part by promising big changes in economic policy — more tax cuts, huge tariffs on imports, mass deportations of immigrants working in the United States illegally. In some ways, his victory marked a repudiation of President Joe Biden’s economic stewardship and a protest against inflation. It came despite low unemployment and steady growth under the Biden administration. What lies ahead for the economy under Trump? Paul Ashworth of Capital Economics spoke recently to The Associated Press. The interview has been edited for length and clarity.
India mourns the passing of former PM Dr. Manmohan Singh, who died at the age of 92 following a prolonged battle with age-related ailments. In recognition of his contributions, the government has declared a seven-day state mourning. Share Market View All Nifty Gainers View All Company Value Change %Change Tributes from across political parties and leaders, including President Murmu, PM Modi, and the Congress leadership, have poured in. His funeral, with full state honours, will take place tomorrow. In economic news, the Indian rupee continues its downward spiral, hitting a record low. On a slightly positive note, the Sensex and Nifty indices gained 1% this week, although market volumes remained thin, and mid-cap stocks remained flat. Auto and pharma stocks saw gains, while metal stocks faced a decline. The government’s latest Household Consumption Expenditure Survey for 2023-24 reveals an encouraging trend in the narrowing consumption gap between urban and rural areas. Rural consumption per capita rose by 9%, while urban areas saw an 8% increase, with the urban-rural consumption gap shrinking from 71% to 70% compared to the previous year. In corporate news, Ultratech Cement has acquired an 8.7% stake in Star Cement for ₹850 crore. This acquisition is expected to be the first phase of a larger stake purchase. Meanwhile, five companies—Concord Enviro, Dam Capital, Mamta Machinery, Sanathan Textiles, and Transrail Lighting—made their stock market debut, with strong initial gains, boosting market sentiment. The government is also considering the creation of an insurance index to track trends in life and general insurance premiums, which could be included in the inflation basket. Meanwhile, Ola Electric is facing significant leadership changes, with the resignation of its Chief Marketing Officer and Chief Technology Officer, adding to the wave of departures, with more than 500 employees leaving the company in recent months. Lastly, the automotive sector mourns the passing of Osamu Suzuki, the visionary who led Suzuki Motors for four decades and helped build Maruti Suzuki, which now commands over 40% of India’s car market share. He was 94 years old. Here are the top 10 buzzing stories from #markets , #business, #economy, and beyond. 'History will be kinder to me': Dr Manmohan Singh's last press conference as Prime Minister Dr Manmohan Singh, India's 13th Prime Minister, died on Thursday, December 26, at the age of 92. Dr Singh served as Indian Prime Minister from 2004 to 2014 and remains one of the most significant leaders in post-independence Indian politics. His journey to the Prime Minister’s Office started as the finance minister in 1991, when he implemented landmark economic reforms. In January 2014, months before the Congress-led UPA government lost the polls to BJP-led NDA, Dr Singh made a profound statement that has resurfaced over the years: “History will be kinder to me than the contemporary media.” This remark was in response to criticism about his leadership, particularly regarding his perceived inability to control his ministers and act decisively in critical situations. You can read more about it here Political leaders across India, including PM Modi, Sonia Gandhi, Arvind Kejriwal, and others, paid tribute to Dr. Singh, acknowledging his contributions to the nation's growth and development. Read more here Madhuri Dixit to Kamal Haasan, celebs pay tribute to ex-PM Dr Manmohan Singh Bollywood celebrities described Singh's passing as a loss to the nation. Celebrities like Madhuri Dixit, Swara Bhasker, Sunny Deol, Diljit Dosanjh, and many others came forward to share heartfelt tributes to the legendary leader. Click here for more deets Rupee posts biggest single-day drop in two years against the US Dollar The rupee tumbled to a record low of 85.81 against the US dollar on Friday, December 27, marking the biggest single-day fall in two years. This decline puts the Indian currency on track for its seventh consecutive year of annual losses against the dollar and its steepest monthly drop in two years. The Indian currency weakened to close at 85.27 against the greenback on Thursday. The rupee breached the 85 mark against the US dollar for the first time on December 19. More deets here Several factors are driving this decline. Firstly, the US Dollar has strengthened, supported by expectations around the incoming Donald Trump administration's policies and the Federal Reserve's hawkish stance on interest rates. Here’s why the rupee is in freefall against the US dollar. Nifty closes 1% higher this week despite thin trading volumes Domestic headline indices closed in the green this week, with the Nifty rising by 1% despite thin trading volumes and lack of cues as the year-end approaches. On Friday, the Sensex advanced 227 points to 78,699, and the Nifty gained 63 points to end at 23,813. The Nifty Bank Index also saw a rise of 141 points, closing at 51,311. "With no major triggers in the near-term, markets are likely to trade near current levels, while investors await December quarter earnings season, which will be the next significant factor shaping the market's trajectory," Siddhartha Khemka, head of research of wealth management at Motilal Oswal Financial Services told Reuters. Full story here Urban-rural consumption gap continues to narrow: Govt survey The Ministry of Statistics & Programme Implementation has released the Household Consumption Expenditure Survey for 2023-24, highlighting key trends in rural and urban spending patterns. The average monthly per capita consumption expenditure (MPCE) in rural areas increased to ₹4,122, while in urban areas it stood at ₹6,996 at current prices. Including the imputed value of free items received through government programmes, the MPCE rose to ₹4,247 for rural areas and ₹7,078 for urban areas. Rural MPCE grew by 9%, while urban MPCE recorded an 8% rise compared to the previous year. The urban-rural gap in MPCE continued to narrow, dropping from 71% in 2022-23 to 70% in 2023-24. You can read the full story here DAM Capital, Mamata Machinery Listing: All five stocks list at a premium December 27 has been the busiest Friday for the exchanges with as many as five IPOs (initial public offering) getting listed in a single day. The shares of these companies — Concord Enviro, Sanathan Textiles, DAM Capital Advisors, Transrail Lighting, and Mamata Machinery — made their stock market debut on Friday, December 27. These five IPOs were open for subscription from December 19 to December 23. Here are all the highlights UltraTech buys 8.69% stake from Star Cement promoter group for ₹851 crore UltraTech Cement Ltd., India's largest cement company by capacity, has announced the acquisition of 8.69% stake in Star Cement Ltd. from its promoter group for ₹851 crore. In an exchange filing on Friday, December 27, UltraTech said that the shares were acquired at a price of ₹235 per share during the block deal window. UltraTech said in its exchange filing that this is a non-controlling minority stake that it has acquired in Star Cement. Star Cement is based out of the north-eastern state of Meghalaya and had reported an overall turnover of ₹2,910 crore in financial year 2024. More deets here Govt is contemplating bringing out an index on insurance pricing: Sources Sources indicate that the government is considering the introduction of an index to track insurance pricing trends, covering both life and general insurance premiums. Watch the accompanying video for more details ⬇️ https://www.youtube.com/watch?v=e41sbbRANdc Ola Electric CMO and CTO resign following major layoffs and retail expansion push Homegrown electric vehicle manufacturer Ola Electric's Chief Marketing Officer (CMO), Anshul Khandelwal, and Chief Technology Officer (CTO), Suvonil Chatterjee, have resigned from their roles, sources confirmed to CNBC-TV18. The exits occurred shortly after a major restructuring initiative announced in November 2024, which involved laying off around 500 employees. The company, however, has yet to issue a comment regarding the departures. Find out more about them here Former Suzuki Motor Chairman Osamu Suzuki, who led company for 40 years, dies at 94 Osamu Suzuki, former chairman of Japan's Suzuki Motor, has died, the company announced Friday. He was 94 years old. Suzuki led the company for more than 40 years, until he stepped down as chairman in 2021, transforming the Shizuoka-based company into a global automaker. Born Osamu Matsuda on January 30, 1930, in Gero, Gifu Prefecture, Japan, Suzuki was the fourth son in a farming family. While his early aspirations leaned toward politics, his career trajectory took a dramatic turn when he married into the Suzuki family, joining the automaker that would come to define his legacy. Read more about him here That’s all folks! Keep yourself up to date with the latest news, views and ideas to make money only on cnbctv18.com . Beyond #Newsroom Follow the CNBC-TV18 channel on WhatsApp Catch crispy news updates on the go!- CNBCTV18 Minis Watch all #videos under one segment- CNBCTV18 Binge We bring you real-time updates and analysis of the stock market- Real-time market updates We'll see you on Monday with another engaging 'Top 10@10.'
75 iconic lighthouses in India saw more than 10L visitors till SeptemberDaily Horoscope For Today, December 3, 2024: Astrological Forecasts For Each Zodiac SignAmerican Airlines Group Inc said that a tech issue with DXC Technology Co, a third-party vendor that maintains the company’s flight-operating systems, caused a brief ground stop on all US flights on Tuesday. The carrier said that a network hardware-related issue has been resolved and flights have resumed. American’s flight-operating system allows for air transport to be coordinated and dispatched, it said. The halt lasted for about an hour. “We sincerely apologise to our customers for the inconvenience,” American said in a statement. “It’s all hands on deck as our team is working diligently to get customers where they need to go as quickly as possible.” The airline didn’t say if it expected any further delays or other knock-on effects. American Airlines had 3,320 domestic flights and 581 international flights scheduled for the day, according to aviation data provider Cirium. Only 19 of its flights were cancelled by the early afternoon, in line with the typical 1% cancellation rate across airlines, Cirium said. But there were delays: Only about 37% of American Airlines flights were leaving on time as of the early afternoon, Cirium said, noting that most airlines aim for 80% of flights departing and arriving within 15 minutes of the scheduled time. The data provider said that most of the delays at American were under two hours. For example, 72% of flights departing out of American’s Dallas hub left within an hour of the scheduled time. “Based on previous such incidents, it appears American has been able to maintain its schedule, albeit with delays,” said Cirium spokesperson Mike Arnot. “There may be an uptick in cancellations later in the day as crews time out.” American Airlines had said earlier it was experiencing technical issues affecting all of its flights, disrupting operations on a day when the Federal Aviation Administration expects to see about 30,000 US flights across all carriers. Some online postings said the airline suffered a software outage preventing it from calculating weight and balance requirements for its flights. The incident comes after Delta Air Lines Inc suffered a multi-day grounding in July affecting thousands of travellers due to a software glitch. Two years ago, Southwest Airlines Co suffered a year-end meltdown involving computer-system issues. Related Story Kam Air commences operations between Kabul and Doha Hot Air Balloon Festival soars to new heights with global enthusiasm
Stronghold Insurance's Romulo I. Delos Reyes, Jr. Honoured As Outstanding Leader At ACES Awards 2024 Media Outreach Newswire APAC
Airport capacity crunch threatens people's freedom to travel, constraining economies
Dore Copper Announces Filing and Mailing of Management Information Circular in Connection with Special Meeting and Encourages Shareholders to Access Meeting Materials Electronically
It’s been nearly 10 years since it was announced that Robert Eggers would be remaking one of the best horror flicks of all time in Nosferatu . Thankfully the long wait is about to come to an end, with the film starring Bill Skarsgård as its titular monster making its debut on the 2024 movie calendar on Christmas Day. It sounds like horror fans might be in for a pretty frightening experience, given that Skarsgård has said his Count Orlok is even more terrifying than Pennywise in It , who he played in the 2017 and 2019 adaptations. First reactions to the 2024 Nosferatu remake seemed to support that claim, as critics were ready to sink their teeth into the movie, which also stars Nicholas Hoult , Lily-Rose Depp and a host of other talent. Let’s see what they’re saying now that they can expand on their initial thoughts, starting with CinemaBlend’s review of Nosferatu . Eric Eisenberg rates the film 4 out of 5 stars, noting the irony but standing by his statement that Robert Eggers has breathed new life into the classic vampire tale, with help from a truly transformed leading actor. He says: It’s Bill Skarsgård’s turn as Count Orlok that is the greatest achievement of Nosferatu. If it weren’t for the fact that the actor’s name is in the cast, one would be hard-pressed to identify him in the role, as it is a full and masterful transformation. His co-stars may not do region-accurate accents, but he entrances with a deep and rolling Romanian brogue, the words uttered from rotting lips beneath a thick, long, black mustache. He emanates control with his presence, but he is also very much an animated corpse. Becky Darke of GamesRadar also gives the upcoming horror movie 4 stars out of 5, saying that despite its relatively straightforward retelling of a classic tale, the sights and sounds are stunning. The critic recommends that movie lovers see this one in theaters in order to fully experience the aural cacophony. Darke concludes: The new Nosferatu is a success; it looks and sounds stunning, is packed with the vampiric horror you’d hope for from the director of such atmospheric works as The Witch and The Lighthouse, is beautifully performed and competently retells a narrative we all know and love. But perhaps this last point is also what stops it from being a perfect movie: it’s solid, but it does very little to push any boundaries of what could be done to bring the ultimate vampire story up to date. Matt Zoller Seitz of RogerEbert.com rates Nosferatu a perfect 4 out of 4 stars. Despite being made with the most modern technology, the movie feels like an artifact from another time, the critic writes. He calls it an “awesome achievement,” writing: Robert Eggers' Nosferatu is a cryptic, beautiful and unsettling experience: transporting in the purest way. The writer-director of The Witch, The Lighthouse and The Northman is a rare filmmaker who seems capable of putting his modern consciousness aside when telling stories. There are no metaphors or analogies, only uncanny things that actually happen. Witches exist, curses and prophecies are real, and a vampire is a monster with the ability not just to shift shapes and drink blood but distort the fabric of reality itself through force of pure evil. Siddhant Adlakha of IGN echoes the sentiment of making the age-old feel fresh, noting Nosferatu ’s scary and sensual approach. The critic rates the movie an “Amazing” 9 out of 10, writing: Nosferatu is Robert Eggers' finest work, given how it both boldly stands on its own as a gothic vampire drama and astutely taps into the original texts — F.W. Murnau's silent classic and Bram Stoker's novel Dracula. This resplendent horror remake keeps the broad strokes of these vampire legends intact, but refashions them into a terrifying, candle-lit tale of bodily autonomy — or lack thereof — that challenges previous versions of the story (and their conceptions of female sexuality) and in which Lily-Rose Depp delivers a harrowing performance opposite Bill Skarsgård's unsettling, corpse-like villain. Liz Shannon Miller of Consequence laments that Bram Stoker’s Dracula has been so thoroughly explored at this point that this movie hitting all the familiar plot beats results in “almost zero suspense.” However, it’s never not beautiful to look at, Miller says, even in its most grotesque moments. The critic grades the modern remake a B and says: Nosferatu delivers exactly what it promised — a new version of a classic tale, told by one of our most technically accomplished filmmakers. And this is certainly a more explicitly sexy version of Nosferatu than what the original German film delivered 102 years ago. However, it otherwise follows its source material, as well as the paths laid out by other adaptations, so faithfully that its most original elements feel drowned out by the familiar. It’s perhaps the best-made Dracula adaptation to come around in a long time. But it never feels essential. So it sounds like no real surprises are in store as far as plot goes, but critics seem to universally agree that Robert Eggers’ direction combined with Jarin Blaschke's cinematography and an ensemble of impressive performances make this worth the price of admission. CINEMABLEND NEWSLETTER Your Daily Blend of Entertainment News Horror movie fans have waited a decade for the Nosferatu remake, and especially after reading such positive things from the critics, it hopefully won’t be too hard to wait another few weeks. The film hits the big screen on Wednesday , December 25.Albion dominated for large periods on a foggy evening at the Amex Stadium and hit the woodwork inside four minutes through Julio Enciso. Bees goalkeeper Mark Flekken also made a string of important saves before being forced off injured in the 36th minute, albeit his replacement Hakon Valdimarsson was rarely tested on his Premier League debut. Brentford, who remain without a top-flight away win this term, had an early Yoane Wissa finish ruled out for offside following VAR intervention but barely threatened, despite an improved second-half showing. The Seagulls remain 10th ahead of Monday’s trip to Aston Villa, with Thomas Frank’s visitors a position and two points below moving towards their New Year’s Day showdown with Arsenal. Brighton have plummeted from second place to mid-table amid a poor run of form which has increased scrutiny on head coach Fabian Hurzeler. Seagulls chief executive Paul Barber called for perspective from fans in his programme notes after revealing he revealed emails “full of doom and gloom” following the recent 3-1 home defeat to rivals Crystal Palace. Enciso, one of two players recalled by Hurzeler following Saturday’s 1-1 draw at West Ham, almost gave Albion a dream start. A poor pass from Bees goalkeeper Flekken was intercepted by Carlos Baleba and, following a neat layoff from Joao Pedro, Paraguay forward Enciso curled against the right post. Brentford arrived in Sussex with the worst away record in the division, having previously taken a solitary point from 24 available this term. Flekken saved well from Baleba and then collected a tame header from the unmarked Enciso before the away side thought they had snatched a 13th-minute lead. After being slipped in by Mads Roerslev at the end of a swift counter-attack, Wissa thumped high into the net beyond Seagulls keeper Bart Verbruggen only to be ruled marginally offside. Flekken made further saves from Brajan Gruda and Matt O’Riley before hurting himself keeping out a deflected Kaoru Mitoma cross and being replaced by 23-year-old Iceland international Valdimarsson. Brentford remained on the back foot and, aside from Wissa’s disallowed effort, offered little going forward in a one-sided opening period which somehow ended level. Brighton defender Jan Paul van Hecke produced a crucial block to deny Wissa as the west London club began the second half brightly before Christian Norgaard’s ambitious effort deflected wide amid groans from increasingly restless home fans. Hurzeler responded with a triple change, introducing Yasin Ayari, Simon Adingra and Yankuba Minteh in place of O’Riley, Gruda and Mitoma. Albion forward Pedro then escaped punishment in the 76th minute after swinging an arm at Bees substitute Yehor Yarmoliuk without making contact before defender Ben Mee became the second visiting player to depart injured. The introduction of Solly March in the 88th minute for his first appearance since suffering a serious knee injury in October last year briefly lifted the mood on the terraces. But, following a frantic five minutes of added time, some Seagulls supporters vented their displeasure at full-time as their club’s wait for victory goes on.