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‘No matter what the results today there will be a strong Green Party in Ireland,’ Eamon Ryan told reporters. The Green Party is set to suffer significant losses in the Irish General Election, with its leader expecting just a handful of parliamentarians to be returned. Children’s Minister Roderic O’Gorman said the party could not buck the trend in Ireland of junior coalition partners in Fine Gael and Fianna Fail governments losing support in subsequent elections. He said they expected to retain two to three seats out of the 12 they had won in the 2020 election on the back of a worldwide “Green wave”. “Undoubtedly it’s a disappointing result for our party today,” Mr O’Gorman told reporters in Ongar, Dublin. “It’s hard for a smaller party in government, that’s long been the tradition, the history in Ireland. We hoped going into the election to buck that but we haven’t been able to buck that today.” Mr O’Gorman, a candidate in Dublin West, is among the outgoing Green Party TDs in a battle to retain their seats. Culture Minister Catherine Martin, who is fighting to remain a Green Party TD for Dublin Rathdown, said it was a “very tight” race in her four-seat constituency. “We go in (to government) not afraid of that because the issue of the climate and biodiversity crisis is (greater) than our survival,” she said on RTE Radio. “I stand over and am proud of our track record of delivery.” Green candidate in Waterford Marc O Cathasaigh said he would not be “in the shake-up” to retain his seat in that constituency, while junior minister Ossian Smyth looks at risk of losing his seat in Dun Laoghaire. Junior minister Joe O’Brien is expected to lose his seat in Dublin Fingal, Neasa Hourigan is at risk in Dublin Central, while Wicklow’s Steven Matthews garnered just 4% of first preferences. Former Green Party leader Eamon Ryan, who announced his retirement from frontline politics in June, said his party had not had a good day. Arriving at the count centre at the RDS in Dublin, the outgoing environment minister told reporters: “If you don’t get elected you accept that, but you come back stronger and you learn lessons, and we’ve done that in the past and we will do that again.” He added: “No matter what the results today there will be a strong Green Party in Ireland, we have deep roots in the community and it’s a very distinct political philosophy and I think there is still space for that in Irish politics, for sure.” Mr Ryan said he did not believe his decision to retire, and the timing of his announcement, had affected the party’s showing. “Unfortunately – and this is just one of those days – we didn’t get the number of votes,” he said. He added: “We’ll look back and see what are the lessons, and what can we learn and what can we do differently. “It’s just one of those days when we didn’t have a good day.
NoneCLUTE — Clute Intermediate has implemented a Texas Association of Future Educators program at the campus, and it already is delivering positive results. Eight students recently competed in an Area 4 TAFE Competition at the University of Houston Downtown in three categories: public speaking, Children’s Lit Pre-K and Interactive Bulletin Board. Several advanced to the state competition. “It’s a student organization created to allow young men and women an opportunity to explore the teaching profession,” Brazoswood High School Teacher Mary Ashley Jimenez said. “I have been the adviser for the Brazoswood TAFE program since 2018.” Only seventh and eighth-grade students can participate in the program at Clute Intermediate. As the Brazoswood High School program grew, Jimenez received help from Principles of Education and Training teacher Cameron Peters. At Brazosport High School, CTE teacher Jaime Moreno works with its FADE program. Students can aspire to become teachers, counselors, social workers, administrators or anything similar. “It’s also a good way for them to become involved in something which is important,” Jimenez said. When Jimenez took TAFE members from Brazoswood High School to the Educators Rising National Competition in Washington D.C., during the summer, she heard middle schools called out alongside the high schools. That inspired her to expand the program in the district, she said. “In my head, I was like, ‘We can do this in BISD too,’” she said. “I decided to start with Clute Intermediate because I am already on their campus a few times a week with my Practicum in Education Brazoswood students. We started the process by having some of the high school TAFE students go to Clute during lunches and do lunch presentations and hand out flyers.” Jimenez decided to bring the program to Clute Intermediate because its students will transfer to Brazoswood High School. “It is very helpful if students already have an idea of what your club is about when they come into high school,” she said. “It also matches up with the Education and Training pathway we offer, which is for students, who are interested in a career working with children and young adults in some way.” At their first competition, the Clute Intermediate students started with public speaking, Children’s Lit Pre-K and an Interactive Bulletin Board. An Interactive Bulletin Board can be any topic, subject or grade for something that can be utilized in a classroom. Seventh-graders Eliza Faltysek and Vivianna Flores did Multiplication Mania for their Interactive Bulletin Board. The board was inspired by a crossword game for people to solve the presented problem. Seventh-graders Jayson Torres and Jarmiah Clay did Solar Science for their Interactive Bulletin Board. “They had to put the planets in order first,” Jimenez said. “Then they had to match the name to it, and then they had to determine the type of terrain.” Eighth-grader A’myriah Patterson’s Interactive Bulletin Board presented Caterpillar Math, in which people had to build and solve a problem. All of those students earned places in the state competition. For the Children’s Lit Pre-K, participants write and illustrate their books. Seventh-grader Cecilia Alvarado made it to state with her book “ABC of Food.” Flores also entered her book about a girl’s first day of school. “I remember that when I was a kid when I was going to a new grade, I’d feel scared because I didn’t have the exact teachers that I knew before and I knew well,” Flores said. Eighth-grader Evangelun Aguirre and seventh-grader Viviana Damian competed in Public Speaking. Damian presented a topic on teacher retention. “I’m more familiar with speaking,” she said. “I’m not afraid to speak in front of other people, and I’m very confident.” Damian wants to be a teacher to impact students and to make school an enjoyable environment, she said. “They researched and found ideas, and we worked on them three times a week during the school day,” Jimenez said. “One of my seniors, James Mann, was also a huge help and would meet at Clute during meeting times and work with the kids.” Brazosport ISD offers numerous options for student growth, such as the Education and Training program, TAFE and Career and Technical Education programs, Jimenez said. Eventually, Jimenez wants to bring TAFE to Lake Jackson Intermediate. “They really do help students build critical skills like communication, creativity, and problem-solving, making them more prepared for careers after high school,” she said. The State Competition will be Feb. 17 at Moody Gardens in Galveston.
Proposed merger would add a differentiated Phase 3 TROP2 Antibody-drug Conjugate (ADC) to the combined company's pipeline PALO ALTO, Calif., Dec. 27, 2024 (GLOBE NEWSWIRE) -- Vincerx Pharma, Inc. (Nasdaq: VINC), a biopharmaceutical company aspiring to address the unmet medical needs of patients with cancer through paradigm-shifting therapeutics, today announced that it has entered into a binding term sheet for a proposed merger with Oqory, Inc., a privately-held, clinical-stage company developing ADCs for the treatment of multiple oncology indications. Upon completion of the proposed merger, Oqory, Inc. will merge with Vincerx Pharma, Inc. Post-closing, Oqory equity holders are expected to own approximately 95% of the combined entity, while Vincerx equity holders will hold about 5%. The transaction includes a minimum fully diluted equity value of $13.66 million for existing Vincerx stockholders at closing and, as a condition to the closing of the merger, completion of a concurrent offering of Vincerx equity securities of at least $20 million. Additionally, Oqory-designated investors will provide interim financing to Vincerx of $1.5 million in two tranches, approximately $1,000,000 of which was funded today through the issuance of common stock and pre-funded warrants along with accompanying common stock warrants and approximately $500,000 of which will be funded on or prior to January 31, 2025. The merger is subject to customary closing conditions, including due diligence, regulatory approvals, negotiation of a definitive merger agreement, stockholder approval from both parties, completion of the minimum $20 million financing, and the continued listing of Vincerx's common stock on Nasdaq. Vincerx is also implementing additional streamlining and cost-control measures, including a workforce reduction, as it pursues due diligence and transaction-related work. As part of this workforce reduction, Dr. Ahmed Hamdy, Chairman and Chief Executive Officer (CEO), has stepped down as CEO but will remain as Chairman. Dr. Raquel Izumi has stepped down as President and Chief Operations Officer and taken over as Acting CEO in a consulting capacity. Alexander Seelenberger has stepped down as Chief Financial Officer, and Kevin Hass, the Company's Vice President and Controller, has taken over as Acting Chief Financial Officer. Mr. Seelenberger has agreed to provide ongoing assistance in a consulting capacity to assist the Company as it pursues its strategic efforts. "This strategic transaction highlights Vincerx's commitment to develop ADCs with improved safety profiles that allow patients to thrive on-rather than endure-their cancer therapies,” said Raquel Izumi, Ph.D., Acting Chief Executive Officer. "Oqory's anti-TROP2 ADC has shown favorable efficacy and safety in the clinic. Among approximately 150 treated patients, results include an 83% overall response rate and 100% disease control rate in first-line triple-negative breast cancer (TNBC; n=30). Unlike other TROP2 ADCs in Phase 3, no cases of interstitial lung disease or Grade 3 and above stomatitis have been reported. Oqory's Phase 3 studies of OQY-3258 are ongoing to confirm these promising findings.” About OQY-3258 (also known as ESG401) OQY-3258 is Oqory's anti-TROP2 ADC with an optimized enzyme-dependent linker technology and an SN-38 payload with established efficacy and manageable side effect profile. OQY-3258 has completed Phase 1/2 development in over 150 patients with solid tumors, including metastatic HR+/HER2- and triple-negative breast cancer. OQY-3258 has shown efficacy in these patients, including reduction of brain metastasis and responses in heavily pretreated patients. To date, OQY-3258 has exhibited a differentiated safety profile vs. Trodelvy and other TROP2 ADCs in Phase 3 development. Notably, no interstitial lung disease or ocular surface events have been observed. Gastrointestinal effects have been mild and mainly Grade 1/2. Neutropenia and leukopenia have been the major AEs, which were manageable and did not result in discontinuation of study drug. OQY-3258 is being evaluated in a Phase 3 study as first-line treatment in patients with unresectable recurrent or metastatic triple-negative breast cancer ( NCT06732323 ) and in a Phase 3 study in patients with unresectable locally advanced or metastatic HR+/HER2- breast cancer ( NCT06383767 ). About Oqory, Inc. Oqory, Inc. is an innovator in the field of ADCs with expertise in advancing targeted cancer therapies. The Company's pipeline includes multiple ADC programs, with two currently in clinical development and several next-generation ADCs in preclinical stages. These programs are designed to address critical unmet needs in indications such as breast cancer, non-small cell lung cancer, small cell lung cancer, multiple myeloma, and other metastatic solid tumors. Powered by a proprietary ADC platform, Oqory is delivering therapies that have demonstrated promising efficacy and safety paving the way for improved patient outcomes. About Vincerx Pharma, Inc. Vincerx Pharma, Inc. is a clinical-stage biopharmaceutical company committed to developing differentiated and novel therapies to address the unmet medical needs of patients with cancer. Vincerx's pipeline consists of a next-generation ADC, VIP943, currently in Phase 1; a small molecule drug conjugate, VIP236, which has completed its Phase 1 study; a CDK9 inhibitor, enitociclib, which has completed a Phase 1 monotherapy study; a preclinical ADC, VIP924; and VersAptxTM, a versatile, next-generation bioconjugation platform. Vincerx is based in Palo Alto, California, and has a research subsidiary in Monheim, Germany. Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (the Securities Act), and Section 21E of the Securities Exchange Act of 1934, as amended, that are intended to be covered by the "safe harbor” created by those sections. Forward-looking statements, which are based on certain assumptions and describe future plans, strategies, expectations and events, can generally be identified by the use of forward-looking terms such as "believe,” "expect,” "may,” "will,” "should,” "would,” "could,” "suggest,” "seek,” "intend,” "plan,” "goal,” "potential,” "on-target,” "on track,” "project,” "estimate,” "anticipate,” or other comparable terms. All statements other than statements of historical facts included in this press release are forward-looking statements. Forward-looking statements include, but are not limited to, the entry into a definitive merger agreement; the anticipated terms and closing of the merger, the $20 million equity investment, and the amount and timing of the interim financing; the expected ownership structure and value to Vincerx stockholders upon closing of the merger; the anticipated benefits of a merger transaction; and the clinical results of Oqory's product candidates. Forward-looking statements are neither historical facts nor assurances of future performance or events. Instead, they are based only on current beliefs, expectations, and assumptions regarding future business developments, future plans and strategies, projections, anticipated events and trends, the economy, and other future conditions. Forward-looking statements are subject to inherent uncertainties, risks, and changes in circumstances that are difficult to predict, many of which are outside Vincerx's control. Actual results, conditions, and events may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause actual results, conditions, and events to differ materially from those indicated in the forward-looking statements include, but are not limited to, Vincerx's capital requirements, availability and sufficiency of capital, and cash runway; the ability of the parties to enter into a definitive merger agreement and the final terms thereof; the parties' ability to satisfy the conditions precedent to the merger, including stockholder approval; the closing of the merger; the risk that any definitive agreement is terminated after it is entered into but before consummation of any proposed merger;; Vincerx's reliance on receipt of interim funding; market acceptance of the combined company; risks associated with clinical development of the Vincerx and Oqory product candidates; general economic, financial, legal, political, and business conditions; and the risks and uncertainties set forth in Vincerx's Quarterly Report on Form 10-Q for the quarter ended September 30, 2024 and subsequent reports filed with the Securities and Exchange Commission by Vincerx. Forward-looking statements speak only as of the date hereof, and Vincerx disclaims any obligation to update any forward-looking statements. Vincerx and the Vincerx logo are trademarks of Vincerx. This press release also contains trademarks and trade names that are the property of their respective owners. Contacts: Gabriela Jairala Vincerx Pharma, Inc. [email protected] Totyana Simien Inizio Evoke Comms [email protected]
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Trump voices support for Hegseth, says he's "doing very well"Romanian presidential election results are SCRAPPED by top court after intelligence reports claim hard-right outsider who surged into lead was backed by Russia By RYAN PROSSER Published: 07:36 AEDT, 7 December 2024 | Updated: 07:50 AEDT, 7 December 2024 e-mail 22 View comments Romania 's top court has annulled the first round of the country's presidential election, which was won by far-right outsider Calin Georgescu. The move comes days after declassified intelligence alleged Russia ran a coordinated online campaign to promote Mr Georgescu. The Constitutional Court's unprecedented decision - which is final - came after President Klaus Iohannis declassified intelligence on Wednesday that alleged Russia ran a sprawling campaign comprising thousands of social media accounts to promote Mr Georgescu across platforms like TikTok and Telegram. Despite being a huge outsider who declared zero campaign spending, Mr Georgescu emerged as the frontrunner on November 24. He was due to face reformist Elena Lasconi of the Save Romania Union party in a run-off on Sunday. Mr Georgescu said the country's democracy was 'under attack' after the court ruled to annul the vote. Calling the decision a 'formalised coup d'etat', the former civil servant, 62, urged Romanians to 'remain faithful to our common ideal'. Mr Iohannis said he would remain in office until a new president is elected in a fresh poll, the date of which will be set once a new government is formed. Calin Georgescu's first round victory in the Romanian presidential elections has been annulled by the nation's Constitutional Court Protesters during a pro-Europe Romania Hopes rally in Bucharest on December 6 Some 951 voting stations had already opened abroad on Friday for the runoff for Romania's large diaspora but had to be halted. As well as the presidential race, Romania also held a parliamentary election which saw pro-Western parties win the most votes but also gains for far-right nationalists. In a televised statement on Friday, Mr Iohannis said he was 'deeply concerned' by the contents of the intelligence reports, which indicated one candidate's campaign was 'unlawfully supported from outside Romania' and was a matter of national security. 'The same candidate declared zero campaign expenditures, despite running a highly sophisticated campaign,' he said. 'Intelligence reports revealed that this candidate's campaign was supported by a foreign state with interests contrary to Romania's. These are serious issues.' Mr Georgescu led the first-round poll with 22.95 per cent of the vote, followed by Ms Lasconi. EU-leaning premier Marcel Ciolacu came third and was eliminated after picking up just 19.15 per cent of votes with 99 per cent counted. Earlier, the European Union said it sent TikTok an urgent request for more information about the Romanian intelligence files suggesting that Moscow coordinated influencers on its platform to promote Mr Georgescu. The 27-nation bloc's executive branch is using its sweeping digital rulebook to scrutinise the video sharing platform's role in the election, which ended with the far-right populist Mr Georgescu seemingly coming out of nowhere to take top spot in the first round of voting. It is unclear from the intelligence release whether Mr Georgescu was aware of the alleged campaign or assisted in it. Mr Georgescu was due to face reformist Elena Lasconi in a second round run-off on Sunday The country's current president, Klaus Iohannis, said he would remain in office until a new leader was selected in a fresh poll European Commission officials said they asked the video sharing platform to comment on the files and to provide information on actions that it is taking in response. It is the second time the commission has asked TikTok for information since the election's first round of voting on November 24, and comes a day after it ordered the Chinese-owned platform to retain all election-related files and evidence. Henna Virkkunen, the commission's executive vice-president for tech sovereignty, security and democracy, said in a post on X: 'We are concerned about mounting indications of coordinated foreign online influence operation targeting ongoing Romanian elections, especially on TikTok.' TikTok has 24 hours to respond to the EU request, officials told a press briefing in Brussels. Russia TikTok Share or comment on this article: Romanian presidential election results are SCRAPPED by top court after intelligence reports claim hard-right outsider who surged into lead was backed by Russia e-mail Add commentTrump taps forceful ally of hard-line immigration policies to head Customs and Border Protection