zhudifeng/iStock via Getty Images Olema Pharmaceuticals, Inc. ( NASDAQ: OLMA ) is ready to advance several clinical programs from its pipeline, and this is thanks to two transactions that were just achieved today. The first transaction would be in terms of the This article is published by Terry Chrisomalis, who runs the Biotech Analysis Central pharmaceutical service on Seeking Alpha Marketplace. If you like what you read here and would like to subscribe to, I'm currently offering a two-week free trial period for subscribers to take advantage of. My service offers a deep-dive analysis of many pharmaceutical companies. The Biotech Analysis Central SA marketplace is $49 per month, but for those who sign up for the yearly plan will be able to take advantage of a 33.50% discount price of $399 per year. Terry Chrisomalis is a private investor in the Biotech sector with years of experience utilizing his Applied Science background to generate long term value from Healthcare. He is the author of the investing group Biotech Analysis Central which contains a library of 600+ Biotech investing articles, a model portfolio of 10+ small and mid-cap stocks with deep analysis for each, live chat, and a range of analysis and news reports to help Healthcare investors make informed decisions. Analyst’s Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article. Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.What Is France's No-Confidence Vote and What Does It Mean for the US?UEC expects losses due to Philippine casino, gaming equipment businesses
The 10 costliest climate disasters in 2024 racked up damage totalling more than 200 billion US dollars, Christian Aid has warned. A report from the charity on hurricanes, floods, typhoons and storms influenced by climate change warns that the top 10 disasters each cost more than 4 billion US dollars in damage (£3.2 billion). The figures are based mostly on insured losses, so the true costs are likely to be even higher, Christian Aid said, as it called for action to cut greenhouse gas emissions and finance for poor countries to cope with climate change. Politicians who “downplay the urgency of the climate crisis only serve to harm their own people and cause untold suffering around the world”, climate expert Joanna Haigh said. While developed countries feature heavily in the list of costliest weather extremes, as they have higher property values and can afford insurance, the charity also highlighted another 10 disasters which did not rack up such costs but were just as devastating, often hitting poorer countries. Most extreme weather events show “clear fingerprints” of climate change, which is driving more extreme weather events, making them more intense and frequent, experts said. The single most costly event in 2024 was Hurricane Milton, which scientists say was made windier, wetter and more destructive by global warming, and which caused 60 billion US dollars (£48 billion) of damage when it hit the US in October. That is closely followed by Hurricane Helene, which cost 55 billion US dollars (£44 billion) when it hit the US, Mexico and Cuba just two weeks before Milton in late September. The US was hit by so many costly storms throughout the year that even when hurricanes are removed, other storms cost more than 60 billion US dollars in damage, the report said. Three of the costliest 10 climate extremes hit Europe, including the floods from Storm Boris which devastated central European countries in September and deadly flooding in Valencia in October which killed 226 people. In other parts of the world, floods in June and July in China killed 315 people and racked up costs of 15.6 billion US dollars (£12.4 billion), while Typhoon Yagi, which hit south-west Asia in September, killed more than 800 people and cost 12.6 billion dollars (£10 billion). Events which were not among the most costly in financial terms but which have still been devastating include Cyclone Chido which hit Mayotte in December and may have killed more than 1,000 people, Christian Aid said. Meanwhile, heatwaves affected 33 million people in Bangladesh and worsened the humanitarian crisis in Gaza, flooding affected 6.6 million people in West Africa and the worst drought in living memory affected more than 14 million in Zambia, Malawi, Namibia and Zimbabwe, the charity said. Christian Aid chief executive Patrick Watt said: “There is nothing natural about the growing severity and frequency of droughts, floods and storms. “Disasters are being supercharged by decisions to keep burning fossil fuels, and to allow emissions to rise. “And they’re being made worse by the consistent failure to deliver on financial commitments to the poorest and most climate-vulnerable countries. “In 2025 we need to see governments leading, and taking action to accelerate the green transition, reduce emissions, and fund their promises.” Dr Mariam Zachariah, World Weather Attribution researcher who analyses extreme events in near-real time to discern the role of climate change, at Imperial College London, said: “This report is just a snapshot of climate devastation in 2024. “There are many more droughts, heatwaves, wildfires and floods not included that are becoming more frequent and intense. “Most of these disasters show clear fingerprints of climate change. “Extreme weather is clearly causing incredible suffering in all corners of the world. Behind the billion-dollar figures are lost lives and livelihoods.” And Prof Haigh, emeritus professor of atmospheric physics at Imperial College London, said: “The economic impact of these extreme weather events should be a wake-up call. “The good news is that ever-worsening crises doesn’t have to be our long-term future. “The technologies of a clean energy economy exist, but we need leaders to invest in them and roll them out at scale.” The 10 costliest climate disasters of 2024 were: – US storms, December to January, more than 60 billion US dollars; – Hurricane Milton in the US, October 9-13, 60 billion US dollars (£48 billion); – Hurricane Helene in the US, Mexico, Cuba, 55 billion US dollars (£44 billion); – China floods, June 9-July 14, 15.6 billion US dollars (£12.4 billion); – Typhoon Yagi, which hit south-west Asia from September 1 to 9, 12.6 billion US dollars (£10 billion); – Hurricane Beryl, in the US, Mexico and Caribbean islands from July 1-11, 6.7 billion US dollars (£5.3 billion); – Storm Boris in central Europe, September 12-16, 5.2 billion US dollars (£4.1 billion); – Rio Grande do Sul floods in Brazil, April 28-May 3, 5 billion US dollars (£4 billion); – Bavaria floods, Germany, June 1-7, 4.45 billion US dollars (£3.5 billion); – Valencia floods, Spain, on October 29, 4.22 billion US dollars (£3.4 billion).
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Opinion editor’s note: Strib Voices publishes a mix of commentary online and in print each day. To contribute, click here . ••• When I was writing about copper mining’s threat to Minnesota’s Boundary Waters five years ago , I drew inspiration from another natural gem to its south. Frontenac State Park hugs a portion of Goodhue County’s Mississippi shoreline and includes a breathtaking overlook of Lake Pepin and its stair-step bluffs. The vista and the hiking paths keep me coming back. But there’s another reason it holds a place in my heart. Perched near the overlook is a plaque honoring John Hauschild, a southern Minnesota farm boy turned prosperous insurance executive. In 1956 , he donated land to what would become Frontenac State Park. As the plaque notes, Hauschild was “profoundly aware of the spectacular view from this site and, through his generosity, has made it possible for you to enjoy.” Those words serve as a reminder not only of special places, but that those who came before us had the foresight to protect them. That long-term vision and commitment to the collective good fills me with gratitude. But it also inspires a soul-searching question: What is my own generation doing to protect other special places for those yet to come? Regrettably, that question became even more difficult to answer after President-elect Donald Trump’s victory in November. Environmental stewardship is a responsibility inherent in good citizenship. This moral obligation didn’t end with Theodore Roosevelt, Minnesota’s wilderness philosopher Sigurd Olson, Everglades protector Marjory Stoneman Douglas and other last-century conservationists no longer with us. There’s still important work to do. As crowded national parks like Yellowstone attest, Americans treasure their natural spaces, even as our growing population strains the boundaries of our current parks and preserves. Other special places are under threat. Sadly, northern Minnesota’s beloved Boundary Waters Canoe Area Wilderness (BWCA) is a prime example. The BWCA is a place so pristine that canoers can fill a cup with the water outside their vessel and drink it. It’s now entering its fourth presidential administration as a political football because of northeast Minnesota’s geological riches: reserves of copper, nickel and other precious metals. Former President Barack Obama and current President Joe Biden, both Democrats, have sought to protect the BWCA and its headwaters from copper-nickel mining, which is notorious worldwide for the environmental devastation it leaves behind. The BWCA’s risk from any runoff is even more acute due to its pure water, which lacks naturally occurring minerals abundant in other locations that mitigate pollution the same way that Rolaids or Tums quell indigestion. In early 2023, Biden took a commendable step that effectively put a 20-year moratorium on copper-nickel mining on 225,000 acres of federally owned land in the BWCA watershed. In contrast, President Trump spent his first term pandering to the Chilean billionaire family that controls Antofagasta, a mining conglomerate that owns Twin Metals Minnesota and seeks to open an underground copper-nickel mine near the BWCA. The proposed mine site is not inside the BWCA, but it’s on its doorstep and at the edge of a lake that drains into the watery wilderness. In July, Trump made clear at a St. Cloud rally his intent to swiftly greenlight the Antofagasta mine. “We will end that ban in, what do you think, about 10 minutes?” Trump vowed last summer. He’s now in a position to start that process, with Republicans controlling the U.S. House and Senate after the election. Last spring, the U.S. House passed a bill to rescind the 20-year moratorium on mining in the BWCA headwaters. Rep. Pete Stauber, who represents northeast Minnesota’s Seventh Congressional District, was the lead author. Because Democrats controlled the Senate, Stauber’s reckless legislation went nowhere after its House passage, but the Senate failsafe is gone. These developments are grim, but there are reasons to remain hopeful: ⋅ Stauber has to reintroduce his bill because a new congressional session starts in 2025. Its previous success doesn’t guarantee passage, especially with the GOP’s razor-thin majority. ⋅ The U.S. House has an eloquent new BWCA advocate in Kelly Morrison, who will succeed Rep. Dean Phillips in the west metro’s Third Congressional District. Morrison previously served in the Minnesota Legislature and was the lead author on a bill that would have provided durable state copper-mining protections in BWCA headwaters. Rep. Betty McCollum, a fierce BWCA protector who represents the east metro’s Fourth Congressional District, also won re-election. ⋅ Minnesota’s two U.S. senators, Amy Klobuchar and Tina Smith, remain in office and wield increasing influence. They understand this issue and its stakes. ⋅ A scientific analysis of copper mining’s risk to the BWCA, one that the Trump administration halted and whose preliminary findings it tried to keep secret , was completed under the Biden administration. Its findings: Contamination is a risk, even with measures designed to head off downstream pollution. These findings should make it more difficult for a federal agency to roll back the 20-year moratorium. ⋅ North Dakota Gov. Doug Burgum, Trump’s pick to lead the U.S. Department of the Interior, an agency with a critical role in protecting federal land, is competent and has lauded Theodore Roosevelt’s conservation ethos. ⋅ Organizations like Minnesota’s Save the Boundary Waters , which has led a savvy legal fight against the Antofagasta mine, are committed for the long haul. Mining advocates will contend that the nation needs copper, especially as the transition continues to renewable energy. I don’t disagree, but that doesn’t entitle us to irresponsibly cast aside our stewardship obligations to future generations. We need to strike a sensible balance, and that requires recognition that mining in some places is far more risky than in others. This particular mine site, perched upstream from a fragile watery wilderness, is one of them.Approximately 85,000 new passports are being held back by Service Canada, which stopped mailing them out a week before the nationwide Canada Post strike. "By holding residential mail several days in advance of a work stoppage, Service Canada has reduced the risk of having any passports held in Canada Post distribution centres," an Employment and Social Development Canada spokesperson told CTVNews.ca. "Those passports will be mailed out once the labour disruption is over and regular mail service resumes." Employment and Social Development Canada operates Service Canada, which issues Canadian passports. Anticipating a potential labour disruption, Service Canada stopped mailing passport packages after Nov. 8. A week later on Nov. 15, approximately 55,000 Canada Post workers went on strike after failing to reach a negotiated agreement with their employer. Mail and parcels will not be accepted, processed or delivered until the strike is over. The spokesperson said anyone who is in urgent need of a passport should call 1-800-567-6868 or visit a Service Canada location that offers passport pick-up to have their package transferred. 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Lifestyle World's tallest and shortest women meet for afternoon tea The world's tallest woman and the world’s shortest woman have met for afternoon tea in London to celebrate Guinness World Records Day. 'That sent my imagination wild': B.C. grandma paints 12-foot Star Wars mural with grandson Sandra Kroek and her grandson Remington spent 200 hours painting a massive Star Wars mural together. Are you a digital nomad? Share your journey of remote work and travel CTVNews.ca wants to hear from digital nomads who have taken up location-independent jobs and can work from anywhere with an internet connection. Sports 1991-2024 | Winnipeg Sea Bears player Chad Posthumus dies at 33 Sea Bears centre Chad Posthumus has died at age 33. 'It's a joke': Italian tennis star crowned world champion after winning Olympic gold can hardly believe her own success It’s fair to say 2024 has been quite a year for Italian tennis, especially for Jasmine Paolini who capped the best season of her career by winning the decisive match in the Billie Jean King Cup Finals against Slovakia to secure Italy’s first title in 11 years. MLB will test robot umpires at 13 spring training ballparks hosting 19 teams Major League Baseball will test robot umpires as part of a challenge system during spring training at 13 ballparks hosting 19 teams, which could lead to regular-season use in 2026. Autos Northvolt says Quebec battery plant will proceed despite bankruptcy filing Northvolt AB has filed for bankruptcy protection in the United States, but said the move will not jeopardize the manufacturer's planned electric vehicle battery plant in Quebec — though hundreds of millions of taxpayer dollars invested in the parent company could be lost. Tired, lead-footed and distracted: Majority of Canadian drivers admit to bad habits, survey finds Canadian drivers are regularly in a hurry to get to their destination and a majority are willing to take unnecessary risks on the road, according to the results of a new survey. B.C. man who sold Porsche to scammers shares cautionary tale A man from B.C.’s Lower Mainland who was scammed while selling his Porsche Cayenne online is sharing his cautionary tale – while calling for increased protections from the government. Shopping Trends The Shopping Trends team is independent of the journalists at CTV News. We may earn a commission when you use our links to shop. Read about us. 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Neel Kamal writes about sustainable agriculture, environment, climate change for The Times of India. His incisive and comprehensive reporting about over a year-long farmers' struggle against farm laws at the borders of the national capital won laurels. He is an alumunus of Chandigarh College of Engineering and Technology. Read More Erica Fernandes radiates beauty in cultural fashion Amyra Dastur stuns in elegant lehenga choli collection Shriya Saran sets bridal fashion goals in a breathtaking red lehenga Radiant pics of Anna Ben 10 iconic beverages from popular countries around the world Sara Ali Khan sets new glam goals in shimmery dresses 10 Himalayan hill stations to visit in December Karisma Kapoor redefines elegance with her ethnic fashion mastery How Allu Arjun became the most stylish superstar in South Indian cinemaBy Echo Wang NEW YORK (Reuters) – Artificial intelligence cloud platform CoreWeave, is aiming for a valuation of more than $35 billion in its U.S. initial public offering that is expected to occur next year, people familiar with the matter told Reuters on Friday. Roseland, New Jersey-based CoreWeave is likely to target raising more than $3 billion from its share sale, which could launch during the second quarter of 2025, the sources said, cautioning that the company’s plans are subject to market conditions and could change. The discussions come at a time when investor interest in generative AI is sky-rocketing. The AI boom, which has powered chipmakers such as Nvidia, and other big tech firms, has turbocharged global demand for infrastructure such as data centers and high-powered servers. Reuters reported in September that data center operator Switch is exploring an IPO that could value the company at about $40 billion, including debt. Funding for private AI and cloud startups in the U.S., Europe and Israel is rising after three years of decline, and is estimated to touch $79.2 billion by the end of this year, venture capital firm Accel said in October. CoreWeave offers access to data centers and high-powered chips for AI workloads, primarily supplied by Nvidia, one of the company’s main backers. It competes against larger cloud computing service providers such as tech giant Microsoft’s Azure and Amazon’s AWS. CoreWeave declined to comment. A broader wave of high-profile names is gearing up for potential listings next year, as the IPO market shows early signs of thawing after several bouts of market volatility shut down capital markets for much of the last two years. CoreWeave recently completed a $650 million secondary share sale, which valued it at $23 billion. Investors led by Jane Street, Magnetar, Fidelity Management, and Macquarie Capital participated in the secondary stock deal. Bloomberg reported in November that CoreWeave had tapped investment banks for its IPO preparations. (Reporting by Echo Wang in New York; Editing by David Gregorio) Disclaimer: This report is auto generated from the Reuters news service. ThePrint holds no responsibilty for its content. var ytflag = 0;var myListener = function() {document.removeEventListener('mousemove', myListener, false);lazyloadmyframes();};document.addEventListener('mousemove', myListener, false);window.addEventListener('scroll', function() {if (ytflag == 0) {lazyloadmyframes();ytflag = 1;}});function lazyloadmyframes() {var ytv = document.getElementsByClassName("klazyiframe");for (var i = 0; i < ytv.length; i++) {ytv[i].src = ytv[i].getAttribute('data-src');}} Save my name, email, and website in this browser for the next time I comment. Δ document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() );
Fears for Gaza hospitals as fuel and aid run low
Ohtani wins third MVP, while Judge takes his secondREDWOOD CITY, Calif., Dec. 02, 2024 (GLOBE NEWSWIRE) -- Biomea Fusion, Inc. (Nasdaq: BMEA) ("Biomea” or the "Company”), a clinical stage biopharmaceutical company focused on the discovery and development of oral covalent small molecules to treat and improve the lives of patients with diabetes, obesity, and genetically defined cancers, today announced that on December 2, 2024, the compensation committee of Biomea's board of directors granted one new employee non-qualified stock options to purchase an aggregate of 30,000 shares of the Company's common stock. The shares underlying the employee's stock options will vest 1/16 on a quarterly basis over four years, subject to the employee's continued employment with the Company on such vesting dates. The above-described award was made under Biomea's 2023 Inducement Equity Plan (the "Plan”). The above-described award was granted as an inducement material to the employee entering into employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4) and was granted pursuant to the terms of the Plan. The Plan was adopted by Biomea's board of directors on November 17, 2023. About Biomea Fusion Biomea Fusion is a clinical-stage biopharmaceutical company focused on the discovery and development of oral covalent small molecules to improve the lives of patients with diabetes, obesity, and genetically defined cancers. A covalent small molecule is a synthetic compound that forms a permanent bond to its target protein and offers a number of potential advantages over conventional non-covalent drugs, including greater target selectivity, lower drug exposure, and the ability to drive a deeper, more durable response. We are utilizing our proprietary FUSIONTM System to discover, design and develop a pipeline of next-generation covalent-binding small-molecule medicines designed to maximize clinical benefit for patients. We aim to have an outsized impact on the treatment of disease for the patients we serve. We aim to cure. Visit us at biomeafusion.com and follow us on LinkedIn , X and Facebook . Contact: Investor & Media Relations Ramses Erdtmann [email protected]
Kaidon Salter is looking for a new home again. Salter, a former Tennessee quarterback, announced on Monday that he plans to enter the NCAA transfer portal after spending the past 4 seasons at Liberty. His career numbers have him completing 59% of his passes for 5,887 yards and 56 touchdowns with 17 interceptions. Salter was most productive in 2023, going 177-of-290 passing (61% complete) for 2,876 yards and 32 touchdowns with just 6 interceptions. In 2024, Salter was 147-of-261 for 1,886 yards, 15 touchdowns and 6 interceptions. Salter also has 19 rushing scores over the past 2 seasons. Salter, from Cedar Hill, Texas, began his college career at Tennessee. He signed as part of the 2021 recruiting class, but was suspended during spring practice and dismissed for a second citation before taking a snap for the Volunteers. Upon leaving Tennessee, Salter elected to play for Hugh Freeze at Liberty. He redshirted in 2021, which makes him a redshirt senior for 2025. In 2022, under Freeze, Salter was 87-of-149 passing for 8 touchdowns and 5 interceptions, rushing 69 times for 284 yards and 2 scores. Jamey Chadwell succeeded Freeze after the coach returned to the SEC taking the Auburn job.Two Red Sox received AL MVP votes for impressive 2024 showings | Sporting NewsLeBron James And Bronny's Opening Game Jerseys Hit Auction Block
Hail Flutie: BC celebrates 40th anniversary of Miracle in MiamiMost shootings in Hartford are followed by rallies by Mothers United Against Violence at the scenes of the crimes. The shootings two weeks ago were especially atrocious, the victims being a 20-year-old woman and her infant son, killed in what police said was a dispute over a car, with the young perpetrator fleeing to Puerto Rico but quickly apprehended there. The rallies always feature appeals to the “community” to stop the violence, as well as a hand-wringing harangue by a street preacher. They often get a couple of minutes on local television newscasts. But what exactly do the rally participants want everyone else to do? They don’t say, and the perpetrators aren’t listening. The rallies serve only to make their participants feel relevant and the TV stations feel as if they have covered the story when they haven’t even touched it. At least the rally-goers notice the violence. These days even the atrocities in the cities pass without comment from the governor, state legislators, and other leaders, who behave, along with journalism, as if the social disintegration sweeping Connecticut but worst in the cities is the natural order of things. It wasn’t always this way. Indeed, historians say that a century ago Hartford was the richest and finest city in the country. Today atrocities like the murder of the young woman and her baby seldom occur outside the cities, an indication that society somehow can be arranged to prevent them in other places. People in authority in Connecticut may claim to be trying to reduce the atrocities, but their frequency indicates that whatever they are doing isn’t working any better than those hapless rallies of lamentation and hand-wringing. Government’s failure to stop social disintegration wasn’t even an issue in last month’s state election and isn’t on the agenda for the session of the state legislature that will convene in a few weeks, though if people listen closely enough the gunshots sometimes can be heard from the grounds of the state Capitol. Many Democrats, including some in Connecticut, are inadvertently signifying that people tend to see and hear only what they want to. These Democrats claim that Donald Trump has just been elected president for a second time because so many voters are racist and bigoted against women and as a result voted against the Democratic nominee for president, Vice President Kamala Harris, a mixed-race woman in an interracial marriage. Of course some voters always will be racist and bigoted. But last week the nonprofit survey organization DataHaven reported that it recently polled more than 7,400 people throughout Connecticut and 40% said they are struggling financially. More people said they are worse off than they were a year ago than said they are better off. A few weeks ago similar surveys by the United Way and Connecticut Voices for Children reported alarming increases in poverty in the state. Connecticut is solidly Democratic but in the election last month Trump substantially increased his share of the vote in the state, even in the overwhelmingly Democratic cities. Are even many Democrats racist and misogynist? Or might the sharp economic decline found by those surveys and others around the country have had more to with the results of the election? While some Democratic leaders acknowledge that their party has lost touch with the working class, few admit the possibility that their party’s last four years in charge of the federal government worsened living standards. Trump may end the U.S. proxy war with Russia in Ukraine even as he makes America nuts again in other respects, as with tariffs and more deficits and inflation. But he is going back to the White House because most voters thought he would be better than the current administration, and no one seems more out of touch on this point than Connecticut’s just re-elected U.S. senator, Chris Murphy. Last week Murphy told an interviewer, “I’m spending most of my time preparing for dystopia,” as if most voters hadn’t already seen enough dystopia under the senator’s own party. Chris Powell (cpowell @ cox.net) has written about Connecticut government and politics for many years.
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