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A new way of treating serious asthma and chronic obstructive pulmonary disease (COPD) attacks could be a “game-changer” and is the first leap in treatment for 50 years, researchers say. Offering patients an injection is more effective than the current care of steroid tablets and cuts the need for further treatment by 30%, according to a study. Benralizumab is a monoclonal antibody that targets specific white blood cells, called eosinophils, to reduce lung inflammation. It is currently used as a repeat treatment for severe asthma at a low dose, but a new clinical trial has found that a higher single dose can be very effective if injected at the time of a flare-up. The findings, published in the Lancet Respiratory Medicine, included 158 people who needed medical attention in A&E for their asthma or COPD attack (COPD is a group of lung conditions that cause breathing difficulties). Patients were given a quick blood test to see what type of attack they were having, with those suffering an “eosinophilic exacerbation” involving eosinophils (a type of white blood cell) being suitable for treatment. Around 50% of asthma attacks are eosinophilic exacerbations, as are 30% of COPD ones, according to the scientists. The clinical trial, led by King’s College London and carried out at Oxford University Hospitals NHS Foundation Trust and Guy’s and St Thomas’ NHS Foundation Trust, saw patients randomly split into three groups. One group received the benralizumab injection and dummy tablets, another received standard care (prednisolone steroids 30mg daily for five days) and a dummy injection, and the third group received both the benralizumab injection and steroids. After 28 days, respiratory symptoms of cough, wheeze, breathlessness and sputum were found to be better in people on benralizumab. And after 90 days, there were four times fewer people in the benralizumab group who failed treatment compared with those receiving steroids. Treatment with the benralizumab injection also took longer to fail, meaning fewer visits to a GP or hospital for patients, researchers said. Furthermore, people also reported a better quality of life on the new regime. Scientists at King’s said steroids can have severe side-effects such as increasing the risk of diabetes and osteoporosis, meaning switching to benralizumab could provide huge benefits. Lead investigator Professor Mona Bafadhel, from King’s, said: “This could be a game-changer for people with asthma and COPD. “Treatment for asthma and COPD exacerbations have not changed in 50 years, despite causing 3.8 million deaths worldwide a year combined. “Benralizumab is a safe and effective drug already used to manage severe asthma. “We’ve used the drug in a different way – at the point of an exacerbation – to show that it’s more effective than steroid tablets, which is the only treatment currently available.” Researchers said benralizumab could also potentially be administered safely at home or in a GP practice, as well as in A&E. First author Dr Sanjay Ramakrishnan, clinical senior lecturer at the University of Western Australia, said: “Our study shows massive promise for asthma and COPD treatment. “COPD is the third leading cause of death worldwide but treatment for the condition is stuck in the 20th century. “We need to provide these patients with life-saving options before their time runs out.” Dr Samantha Walker, director of research and innovation at Asthma and Lung UK, welcomed the findings but said: “It’s appalling that this is the first new treatment for those suffering from asthma and COPD attacks in 50 years, indicating how desperately underfunded lung health research is.” AstraZeneca provided the drug for the study and funded the research, but had no input into trial design, delivery, analysis or interpretation.No. 4 Penn State tries to keep playoff picture out of focus in prep for tough trip to Minnesota
Rajasthan United FC staged a stunning second-half comeback to beat hosts Namdhari FC 3-1 in the I-League here on Saturday (November 30, 2024). Namdhari took a fortunate lead in the 18th minute when Rajasthan defender Wayne Vaz, under pressure from Akashdeep Singh, scored an own goal. The hosts dominated early, with Akashdeep coming close to doubling the lead in the 34th minute, only for Rajasthan goalkeeper James Kithan to deny him with a superb save. Rajasthan grew into the game and equalised in the 51st minute after William Neihsial was fouled in the box and Alain Oyarzun converted the resultant penalty with ease. Namdhari nearly regained the lead in the 70th minute, but Cledson Dasilva’s header drifted narrowly wide. Three minutes later, Seiminmang Manchong dribbled past multiple defenders and fired in a low shot that eluded goalkeeper Jaspreet Singh, putting Rajasthan ahead. Namdhari’s hopes faded after a red card in the 80th minute, and Wayne Vaz redeemed himself in the 85th minute, tapping in from close range to seal Rajasthan’s victory. Later in the evening, Dempo SC clinched their maiden victory of the season, defeating hosts Shillong Lajong FC 2-0. Goals from Pruthvesh Pednekar (53’) and Matija Babović (90’) sealed a crucial away win for Samir Naik’s men, building on their opening draw against Aizawl FC. The match began evenly, with Lajong’s Damaitphang Lyngdoh testing Dempo goalkeeper Ashish Sibi early on. Despite creating chances, Lajong failed to convert, with Daniel Gonçalves missing a key opportunity. Dempo’s disciplined defense soaked up the pressure, keeping the first half goalless. The Goan side shifted gears after the break when Pednekar broke the deadlock, heading home a corner from Cristián Pérez. Lajong’s attempts to equalise were thwarted by Sibi’s stellar saves, including a vital stop against Phrangki Buam. Babovic sealed the win in stoppage time with a sensational long-range strike that left Lajong goalkeeper Neithovilie Chalieu rooted. Published - December 01, 2024 05:12 am IST Copy link Email Facebook Twitter Telegram LinkedIn WhatsApp Reddit Football / sport