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Alpheus Medical Announces Positive Phase 1/2 Trial Results for the Treatment of Recurrent High-Grade GliomasNoneIndia mosque survey sparks clashes, two dead
Bowls miss out in 4 CFP teams in latest postseason twistCHANHASSEN, Minn. , Nov. 24, 2024 /PRNewswire/ -- Alpheus Medical, Inc., a private, clinical-stage oncology company pioneering sonodynamic therapy (SDT) for the treatment of solid body cancers, today announced positive results from their Phase 1/2 clinical trial in patients with recurrent or refractory high-grade gliomas. The company's proprietary therapy demonstrated a strong safety profile and extended median overall survival (OS) and progression-free survival (PFS) compared to historical data. The data were presented by Michael Schulder , MD, at the 2024 Society of Neuro-Oncology (SNO) Annual Meeting. "Glioblastomas are the most common and aggressive primary brain cancer, presenting a devasting diagnosis for patients and their familes," said David Reardon , MD, Clinical Director of the Center for Neuro-Oncology at Dana-Farber Cancer Institute, and member of the Alpheus Medical Scientific Advisory Board. "Current treatment options are limited and often ineffective due to the diffuse spread of the disease across the blood-brain barrier and often across the entire hemisphere, making it universally fatal with a rapid timeline. The early clinical results of Alpheus's therapy are promising, offering hope for this new approach. I look forward to further exploring the potential benefits of their SDT therapy for this patient population who is in critical need of an effective solution." Alpheus Medical's non-invasive SDT treatment, which can be delivered in an outpatient setting, combines low-intensity diffuse ultrasound (LIDU TM ) with oral 5-aminolevulinic acid (5-ALA) to target and kill cancer cells across the entire hemisphere without the need for imaging or sedation. Key findings from the study include: "In addition to the strong safety data and early indications of efficacy, Alpheus' non-invasive SDT therapy stands out for its ease of use - a significant improvement over the uncomfortable and often toxic treatments currently available for this rapidly fatal condition," stated Dr. Schulder, Director of the Brain Tumor Center at Northwell Health, and one of the trial's primary investigators. "We look forward to expanding the ability for patients to receive this promising therapy." The Phase 1/2 trial ( NCT05362409 ) is an open-label, multicenter, duration-escalation study evaluating the safety, optimal dose, and efficacy of Alpheus Medical's proprietary SDT platform. Twelve patients were enrolled across three cohorts, with treatment durations escalating to 60, 90, and 120 minutes per monthly session. The company plans to initiate a randomized, controlled trial at multiple centers across the U.S. in 2025. About Alpheus Medical, Inc. Alpheus Medical is a private, clinical-stage oncology company revolutionizing the treatment of solid body cancers with its pioneering sonodynamic therapy (SDT) platform that combines Low-Intensity Diffuse Ultrasound (LIDU TM ) with the sensitizing agent, oral 5-aminolevulinic acid (5-ALA). The company's proprietary, non-invasive technology is designed to selectively target and destroy cancer cells in the brain while preserving healthy tissue. Learn more at www.alpheusmedical.com . Media Contact Carla Benigni carla@sprigconsulting.com View original content to download multimedia: https://www.prnewswire.com/news-releases/alpheus-medical-announces-positive-phase-12-trial-results-for-the-treatment-of-recurrent-high-grade-gliomas-302314785.html SOURCE Alpheus MedicalNone
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Subscribe Search Search Sort by Relevance Title Date Subscribe ALBAWABA - Nearly all Gen Z workers are utilizing AI tools on daily basis, according to a new Google Workspace survey conducted with The Harris Poll revealing how younger knowledge workers are driving the use of AI technologies and changing how work is done across sectors. Also Read Quarter of Google's new code is AI generated, CEO reveals According to the survey, 79% of millennials (ages 28–39) and 93% of Gen Z workers (ages 22–27) use at least two AI products each week. These tools, which include ChatGPT, Otter.ai, and DALL-E, are mostly used to help with tasks like note-taking automation, document refinement, and email composition. "Almost all (98%) of those surveyed anticipate that AI will have an impact on their industry or workplace within the next 5 years." Full survey, via Google Workspace: https://t.co/N2sudkjvA1 — Morning Brew ☕️ (@MorningBrew) November 25, 2024 86% of participants think AI may improve leadership capacities by facilitating better management practices and boosting communication, and a remarkable 98% expect substantial AI-driven developments in their sectors over the next five years. “Rising leaders are not just exploring AI, they’re integrating it into workflows to enhance communication and focus on strategic work,” says Yulie Kwon Kim, VP of Product at Google Workspace. However, Concerns regarding AI persist, regardless of their advantages. Gen Z, in particular, are reportedly experiencing anxieties regarding their employment security, with 62% of them anticipating that AI might replace them within the next decade. In contrast, these concerns are felt by only 6% of senior executives, Fortune reports. While AI chatbots can assist in the automation of work and the completion of repetitive duties, such as proofreading texts or composing emails, employers such as Apple and JPMorgan Chase have implemented limitations on the utilization of ChatGPT over concerns regarding their inappropriate utilization and potential of errors. A passionate about the Gaming Industry with a career of over 5 years in the field, I write about current trends and news in the Game Development business and how it impact the industry and players. Laith has recently started a new position at Al Bawaba as a freelance business writer. Subscribe Sign up to our newsletter for exclusive updates and enhanced content Subscribe Now Subscribe Sign up to get Al Bawaba's exclusive celeb scoops and entertainment news Subscribe to our newsletter for exclusive updates and enhanced content Subscribe
(Reuters) -Alphabet's Google asked a U.S. appeals court on Wednesday to throw out a jury verdict and a judge's order forcing it to revamp its app store Play. In its first detailed argument to the San Francisco-based 9th U.S. Circuit Court of Appeals, Google said the trial judge made legal errors that unfairly benefited the plaintiff, "Fortnite" maker Epic Games. Requiring a "dramatic redesign" of Google Play and its mobile-device operating system Android will hurt app developers and consumers, Google said in its court filing. Epic in a statement on Wednesday said Google was relying on “flawed arguments” that the jury rejected. “This meritless appeal is Google’s desperate attempt to avoid complying with the unanimous jury decision,” Epic said. Google declined to comment beyond its court filing. Epic’s 2020 lawsuit accused Google of monopolizing how consumers access apps on Android devices and how they pay for transactions within apps. The Cary, North Carolina-based company persuaded a San Francisco jury last year that Google illegally stifled competition. Based on the jury's findings, U.S. District Judge James Donato ordered Google in October to let users download rival app stores within Play and make Play's app catalog available to those competitors, among other reforms. The order, which would bind Google for three years, is on hold pending review in the 9th Circuit. Google told the appeals court on Wednesday that a jury should never have heard Epic's lawsuit because it sought to enjoin Google's conduct, not collect damages. It said Donato unfairly allowed Epic to tell jurors that Google and Apple are not competitors for app distribution and in-app payments. The filing said Donato was wrong to issue an injunction affecting users and developers nationwide, not just Epic. Google said the order made Donato "a central planner responsible for product design." The 9th Circuit said it will hear oral arguments on Feb. 3, with a ruling expected later next year. (Reporting by Mike Scarcella; Editing by David Bario, Rod Nickel, David Gregorio and Jonathan Oatis)
Last week, ( ) reported its third-quarter earnings for fiscal 2025. For the quarter, the company posted revenue and diluted EPS (earnings per share) growth of 5.7% and 6.5%, respectively. Its same-store sales grew 3.3%, a decline from 4.7% in the previous quarter. Weaker same-store sales and an expensive valuation appear to have made investors nervous, leading to a selloff. The company has lost 5.4% of its stock price since reporting its third-quarter earnings. Let’s assess its third-quarter performance and future growth prospects to determine whether investors should utilize the pullback to accumulate the stock to earn superior returns. Dollarama’s third-quarter performance Dollarama has posted of $1.6 billion, representing a 5.7% increase from the previous year. The net addition of 60 stores over the last four quarters and positive same-store sales of 3.3% drove its topline. A 5.1% increase in transactions overcame a 1.7% decline in average transaction size to drive its same-store sales. Strong demand for consumables offset the softer demand for seasonal items, boosting its same-store sales. The discount r’s gross margins contracted 70 basis points to 44.7% amid higher sales of lower-margin consumable products and increased logistics expenses. However, its SG&A (selling, general, and administrative) expenses as a percentage of total revenue fell from 14.5% to 14.3% amid the favourable impact of scaling. Its adjusted EBITDA (earnings before interest, tax, depreciation, and amortization) grew 6.5% to $509.7 million, while its adjusted EBITDA margin expanded from 32.4% to 32.6%. Moreover, the contribution from Dollarcity, where Dollarama owns 60.1%, to Dollarama’s net income increased from $18 million to $27.1 million with an increased stake. Supported by the increased contribution from Dollarcity, Dollarama has posted a diluted EPS of $0.98, representing 6.5% year-over-year growth. Now, let’s look at its growth prospects. Dollarama’s growth prospects Amid positive customer response to its value offerings and a reevaluation of its market potential in Canada, Dollarama has increased its store expansion plan from 2,000 stores to 2,200 by 2034. Also, the company has planned to build a logistics hub in Western Canada, which could support its future growth and improve operating efficiency. Apart from $46.7 million in land acquisition expenses, the company plans to invest around $450 million to construct its Western hub facility in Calgary, Alberta. The company expects to incur capital expenditures for the facility over the next three years and hopes to commission the project by the end of 2027. Given its capital-efficient business model, quick sales ramp-up, and lower payback period of two years, these expansions could boost its top and bottom lines. Moreover, Dollarama’s subsidiary, Dollarcity, expanded its footprint by opening 18 stores in the third quarter, thus raising its store count to 588. Meanwhile, it has a solid development pipeline and hopes to increase its store count to 1,050 by the end of fiscal 2031. Besides, Dollarama owns an option to increase its stake in Dollarcity by 9.9% by the end of 2027. So, Dollarama’s growth prospects look healthy. Investors’ takeaway Despite the recent pullback, Dollarama trades at over 47% higher this year, outperforming the broader equity markets. Also, its valuation looks expensive, with its NTM (next 12 months) multiple at 32.1. However, given its healthy growth prospects and solid underlying business, investors are ready to pay a premium, justifying its higher valuation. So, considering its growth prospects and impressive underlying business, I believe the pullback offers an excellent buying opportunity for long-term investors.
PSV staged a dramatic Champions League comeback against 10-man Shakhtar Donetsk in Eindhoven, winning 3-2 from two goals down in the 87th minute. The visitors went in front after just eight minutes from a quick breakaway, with Yukhym Konoplia setting up Danylo Sikan, whose shot squeezed beyond PSV keeper Walter Benítez. Oleksandr Zubkov doubled Shakhtar’s lead with a superb curling finish in the 37th minute, putting the Ukrainians in control of the match. Despite PSV having numerous efforts on goal, Shakhtar looked largely untroubled until Pedro Henrique was sent off for a dangerous challenge on Johan Bakayoko in the 69th minute. That allowed the hosts to pile on the pressure, but they were kept out until Malik Tillman’s free kick squeezed past Dmytro Riznyk at the near post. Tillman brought Peter Bosz’s side level on 90 minutes with a thumping strike from outside the area. With Shakhtar’s defence all at sea, Ricardo Pepi finished off a passing move with a shot that went in off the post, his 95th-minute winner sparking delirium among the home supporters. Benfica came from behind twice to end 10-man Monaco ’s unbeaten Champions League start, scoring two late headers to grab a thrilling 3-2 away win. Monaco’s Eliesse Ben Seghir got his side off to the perfect start, breaking the deadlock in the 13th minute by rifling home from Aleksandr Golovin’s cut-back. Ángel Di María and Nicolás Otamendi both went close for Benfica before half time, with Monaco’s Breel Embolo smacking a shot off the post soon after the restart. That miss that proved costly when Benfica’s Vangelis Pavlidis made the most of Caio Henrique’s weak header to steal the ball and equalise. Both sides then had goals ruled out for offside by VAR, before Monaco defender Wilfried Singo picked up his second yellow card just before the hour mark. Despite that setback, Monaco retook the lead as substitute Soungoutou Magassa charged on to Christian Mawissa’s angled pass and drilled home for his first goal for the club. But Di María had the final say, crossing for Arthur Cabral to level in the 84th minute, then picking out Zeki Amdouni to head home the winner four minutes later. Borussia Dortmund eased past hosts Dinamo Zagreb 3-0 to stay firmly on course for a top-eight finish and an automatic place in the last 16. Jamie Gittens fired last year’s finalists into a deserved lead in the 41st minute, finishing well after Danijel Zagorac had spectacularly kept out Donyell Malen’s point-blank header. Ramy Bensebaini headed in Dortmund’s second goal from a corner early in the second half. Forward Serhou Guirassy, back after a short illness, got on the scoresheet late in the game. The substitute broke clear of the Zagreb defence and ran on a deflected pass before slotting the ball through the keeper’s legs. Lille boosted their bid for a top-eight finish with a 2-1 away win at Bologna , whose hopes of reaching the knockout rounds look slim. Ngal’ayel Mukau opened the scoring for the visitors just before the break, and while Jhon Lucumi got Bologna’s first Champions League goal in the 63rd minute, Mukau struck again just three minutes later to earn victory. Sign up to Football Daily Kick off your evenings with the Guardian's take on the world of football after newsletter promotion Earlier on Wednesday, Red Star Belgrade came from a goal down to thrash visitors Stuttgart 5-1 and earn their first league-phase points in emphatic fashion. Ermedin Demirovic volleyed in from close range to give the visitors a fifth-minute lead but Silas, on loan from Stuttgart, levelled for the hosts seven minutes later. With Red Star’s fans growing louder, their team took the lead in the 31st minute with a fierce volley from Rade Krunic. Red Star were able to break through Stuttgart’s high line at will, wasting chances with two consecutive counters before Silas firing over the bar from close range. Mirko Ivanic then headed in at the far post in the 65th minute to make it 3-1 before another Nemanja Radonjic added gloss to the scoreline with two goals off the bench. Girona ’s struggles in the competition continued as they lost 1-0 at Sturm Graz in Wednesday’s other early kick-off. Mika Biereth’s second-half goal, scored on the rebound after Paulo Gazzaniga’s save, secured the hosts’ first points of the league phrase and their first win over a Spanish side in Europe.
HealthEquity Reports Third Quarter Ended October 31, 2024 Financial Results– Presidential spokesperson has dismissed speculation of discord among the country’s top leadership, asserting that and his deputies, and , are united in their focus on governance and improving the lives of Zimbabweans. Charamba made the remarks in an interview on Friday, stressing that the government’s top echelon remains committed to addressing socio-economic challenges and fulfilling the promises of the ruling party. “There is no noise in the government cockpit. The president and his deputies are working seamlessly, focusing on issues that matter to the people rather than engaging in politics,” Charamba said. The comments come amid persistent rumours of factionalism within the ruling party, particularly between Mnangagwa and Chiwenga. These speculations have been fuelled by past events, including perceived rivalries during Zanu PF’s internal succession battles and key policy disagreements. Charamba, however, rubbished these claims, saying they are “a product of wishful thinking” by opposition groups and detractors. “This administration is focused on delivering tangible results, not on politicking. Those hoping for divisions within Zanu PF will be disappointed,” Charamba added. According to Charamba, the government is prioritising key development projects in line with its agenda, which aims to transform Zimbabwe into an upper-middle-income economy. He highlighted ongoing efforts in infrastructure development, agriculture, and industrial revitalisation as evidence of the leadership’s unified focus. “The president and his deputies are working together to ensure progress in energy generation, food security, and job creation. These are the pressing issues, not the gossip being peddled on social media,” he said. Zimbabwe is grappling with significant economic challenges, including high inflation, currency instability, and unemployment. Despite these difficulties, Charamba argued that the government remains steadfast in its objectives, buoyed by recent improvements in agricultural output and infrastructure investments. The spokesperson also pointed to recent engagements with international investors and regional bodies as signs of the administration’s commitment to repositioning Zimbabwe on the global stage. Critics, including opposition parties, have accused the Mnangagwa administration of failing to prioritise reforms that would stabilise the economy and address corruption. , ex-leader of the opposition , recently criticised the government for what he described as “window dressing,” claiming that real progress requires addressing systemic governance issues. As Zimbabwe heads into 2025, the unity of Mnangagwa, Chiwenga, and Mohadi could prove pivotal in navigating political and economic challenges. Charamba’s assurances aim to project an image of stability and focus, but analysts say the administration must address pressing issues such as foreign currency shortages, debt repayment, and political tensions to solidify its legacy. Observers suggest that maintaining harmony in the leadership ranks will be critical for ensuring the success of large-scale initiatives, such as the and the ambitious , both of which are key pillars of the Vision 2030 framework. For now, the government’s official line is clear: no turbulence, just progress.
NoneA court challenge over a Stormont vote on extending post-Brexit trading arrangements for Northern Ireland has been dismissed, and the Assembly debate will go ahead as planned on Tuesday. Ruling on Monday after an emergency hearing at Belfast High Court, judge Mr Justice McAlinden rejected loyalist activist Jamie Bryson’s application for leave for a full judicial review hearing against Northern Ireland Secretary Hilary Benn. The judge said Mr Bryson, who represented himself as a personal litigant, had “very ably argued” his case with “perseverance and cogency”, and had raised some issues of law that caused him “some concern”. However, he found against him on the three grounds of challenge against Mr Benn. Mr Bryson had initially asked the court to grant interim relief in his challenge to prevent Tuesday’s democratic consent motion being heard in the Assembly, pending the hearing of a full judicial review. However, he abandoned that element of his leave application during proceedings on Monday, after the judge made clear he would be “very reluctant” to do anything that would be “trespassing into the realms” of a democratically elected Assembly. Mr Bryson had challenged Mr Benn’s move to initiate the democratic consent process that is required under the UK and EU’s Windsor Framework deal to extend the trading arrangements that apply to Northern Ireland. The previously stated voting intentions of the main parties suggest that Stormont MLAs will vote to continue the measures for another four years when they convene to debate the motion on Tuesday. After the ruling, Mr Bryson told the court he intended to appeal to the Court of Appeal. Any hearing was not expected to come later on Monday. In applying for leave, the activist’s argument was founded on three key grounds. The first was the assertion that Mr Benn failed to make sufficient efforts to ensure Stormont’s leaders undertook a public consultation exercise in Northern Ireland before the consent vote. The second was that the Secretary of State allegedly failed to demonstrate he had paid special regard to protecting Northern Ireland’s place in the UK customs territory in triggering the vote. The third ground centred on law changes introduced by the previous UK government earlier this year, as part of its Safeguarding the Union deal to restore powersharing at Stormont. He claimed that if the amendments achieved their purpose, namely, to safeguard Northern Ireland’s place within the United Kingdom, then it would be unlawful to renew and extend post-Brexit trading arrangements that have created economic barriers between the region and the rest of the UK. In 2023, the UK Supreme Court unanimously ruled that the trading arrangements for Northern Ireland are lawful. The appellants in the case argued that legislation passed at Westminster to give effect to the Brexit Withdrawal Agreement conflicted with the 1800 Acts of Union that formed the United Kingdom, particularly article six of that statute guaranteeing unfettered trade within the UK. The Supreme Court found that while article six of the Acts of Union has been “modified” by the arrangements, that was done with the express will of a sovereign parliament, and so therefore was lawful. Mr Bryson contended that amendments made to the Withdrawal Agreement earlier this year, as part of the Safeguarding the Union measures proposed by the Government to convince the DUP to return to powersharing, purport to reassert and reinforce Northern Ireland’s constitutional status in light of the Supreme Court judgment. He told the court that it was “quite clear” there was “inconsistency” between the different legal provisions. “That inconsistency has to be resolved – there is an arguable case,” he told the judge. However, Dr Tony McGleenan KC, representing the Government, described Mr Bryson’s argument as “hopeless” and “not even arguable”. He said all three limbs of the case had “no prospect of success and serve no utility”. He added: “This is a political argument masquerading as a point of constitutional law and the court should see that for what it is.” After rising to consider the arguments, Justice McAlinden delivered his ruling shortly after 7pm. The judge dismissed the application on the first ground around the lack consultation, noting that such an exercise was not a “mandatory” obligation on Mr Benn. On the second ground, he said there were “very clear” indications that the Secretary of State had paid special regard to the customs territory issues. On the final ground, Justice McAlinden found there was no inconsistency with the recent legislative amendments and the position stated in the Supreme Court judgment. “I don’t think any such inconsistency exists,” he said. He said the amendments were simply a “restatement” of the position as set out by the Supreme Court judgment, and only served to confirm that replacing the Northern Ireland Protocol with the Windsor Framework had not changed the constitutional fact that Article Six of the Acts of Union had been lawfully “modified” by post-Brexit trading arrangements. “It does no more than that,” he said. The framework, and its predecessor the NI Protocol, require checks and customs paperwork on goods moving from Great Britain into Northern Ireland. Under the arrangements, which were designed to ensure no hardening of the Irish land border post-Brexit, Northern Ireland continues to follow many EU trade and customs rules. This has proved highly controversial, with unionists arguing the system threatens Northern Ireland’s place in the United Kingdom. Advocates of the arrangements say they help insulate the region from negative economic consequences of Brexit. A dispute over the so-called Irish Sea border led to the collapse of the Northern Ireland Assembly in 2022, when the DUP withdrew then-first minister Paul Givan from the coalition executive. The impasse lasted two years and ended in January when the Government published its Safeguarding the Union measures. Under the terms of the framework, a Stormont vote must be held on articles five to 10 of the Windsor Framework, which underpin the EU trade laws in force in Northern Ireland, before they expire. The vote must take place before December 17. Based on the numbers in the Assembly, MLAs are expected to back the continuation of the measures for another four years, even though unionists are likely to oppose the move. DUP leader Gavin Robinson has already made clear his party will be voting against continuing the operation of the Windsor Framework. Unlike other votes on contentious issues at Stormont, the motion does not require cross-community support to pass. If it is voted through with a simple majority, the arrangements are extended for four years. In that event, the Government is obliged to hold an independent review of how the framework is working. If it wins cross-community support, which is a majority of unionists and a majority of nationalists, then it is extended for eight years. The chances of it securing such cross-community backing are highly unlikely.