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Crizanlizumab is under clinical development by and currently in Phase II for Chronic Kidney Disease (Chronic Renal Failure). According to GlobalData, Phase II drugs for Chronic Kidney Disease (Chronic Renal Failure) have a 48% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Crizanlizumab overview Crizanlizumab-TMCA (Adakveo, ) is a monoclonal antibody, produced by using recombinant DNA technology in chinese hamster ovary (CHO) cells. It is formulated as solution and concentrate solution for intravenous route of administration. Adakveo is indicated to reduce the frequency of vasoocclusive crises (VOCs) in adults and pediatric patients aged 16 years and older with sickle cell disease. Crizanlizumab (SEG101, SelG-1) is under development for the treatment of sickle cell disease, vaso-occlusive crisis associated with sickle cell disease. chronic kidney disease due to sickle cell nephropathy and primary myelofibrosis including post-essential thrombocythemia (ET) (PET-MF), post-polycythemia vera (PV) myelofibrosis (PPV-MF) and COVID-19 vasculopathy. The therapeutic candidate is administered as an intravenous infusion. It is a humanized monoclonal antibody that acts by targeting P-selectin. Novartis overview is a healthcare company that focuses on the discovery, development, manufacture and marketing of prescription and generic pharmaceutical products and eye care products. It provides drugs for the treatment of cancer, cardiovascular diseases, dermatological conditions, neurological disorders, ophthalmic and respiratory diseases, hematologic diseases, solid tumors, immune disorders, and infections, among others. conducts research in various disease areas through the BioMedical Research division. The company operates through a network of subsidiaries and offices across the Americas, Europe, the Middle East, Africa and Asia-Pacific. is headquartered in Basel, Switzerland. For a complete picture of Crizanlizumab’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
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On Saturday, billionaire CEO of Tesla and SpaceX Elon Musk praised India’s election system for its impressive efficiency in counting 640 million votes within a single day. Musk’s remarks came in response to a post on X that highlighted the article “How India Counted 640 Million Votes in a Day”. His comments compared the speed of India’s vote counting with the slower process in California saying, “India counted 640 million votes in 1 day. California is still counting votes.” But this efficiency is not without its critics — one of them ironically being Musk himself. First, for some context — it is important to note that in India, Electronic Voting Machines are the standard means of conducting elections which helps with quick counting. Alternatively, more Americans now vote through paper ballots. Due to this dependency on mail-in paper ballots, many areas, including California, experience delays in vote counting. Now coming to what Musk said. In July 2024, the tech mogul called for the elimination of electronic voting machines in the US, citing risks of hacking by humans or AI. Here Musk’s stance feels very paradoxical to his current statement — while he admires India’s ability to deliver quick results, his scepticism of EVMs might feel out of sync with India’s own trust in the technology. In the tweet Musk wrote: “Electronic voting machines and anything mailed in is too risky. We should mandate paper ballots and in-person voting only.” At that point, Musk’s comments had sparked a strong response from former Minister of State for IT Rajeev Chandrasekhar, who criticised them as an “oversimplification.” Chandrasekhar’s reaction came against the backdrop of ongoing debates in India over the reliability of EVMs. He said, “Elon Musk’s view may apply to the US and other places – where they use regular compute platforms to build Internet-connected voting machines. Electronic voting machines can be architected and built right, as India has done. We would be happy to run a tutorial, Elon.” Even today a parallel debate is emerging among politicians and civil society activists advocating for a return to paper ballots, considered the “gold standard” for elections. Taking these points into consideration, as citizens we must think about the efficiency of these machines over paper and what is more important — speed or reliability?
...Lists National Assembly’s legislative interventions Senator Opeyemi Bamidele, leader of the Senate, has extended warm greetings to Nigerians on the occasion of Christmas. In a release he personally signed, Opeyemi also listed some of the interventions the National Assembly has made since inauguration last year. “2024 Christmas Message Christmas, again, presents humanity the opportunity to appreciate God Almighty for His redemption plan and the birth of Jesus Christ, whom we are all celebrating today. “Christ is indeed the real reason for this season and nothing more. It is not just a season for winning and dining, but also of deep reflection about Christ’s birth and mission, about His care and love, and about His sacrifice and travail for us all, even for the unborn generations,” he said. According to Opeyemi, “The reason for the season is, no doubt, a huge lesson for all humanity far and near. As we celebrate His faithfulness and goodness in our homes, we must also remember the needy in our neighbourhoods and consciously minister to them as Christ will have done. “We need to reflect on the travail of the vulnerable nationwide and rekindle enduring hope in their hearts. We must reach out to those in troubled areas and show them the care of Christ our Lord.In this season and beyond, we must likewise remember Nigeria, our Fatherland and the only country of our common heritage. “With the zeal of our Lord, we must offer our timeless prayers for the renaissance of our Fatherland, for the restoration of her economy, for the stability of her polity, for the cohesion of her people across the Niger and for the manifestation of her glory in the league of Nations. “This is the season never to shy away from eternal responsibilities God Almighty has committed to our hands. This is the season to renew our resolve to faithfully stand with the political leadership for the renewal of hope. “This is the season to halt the search for pastures that are never green, but the time to join hands together to build our own Nation with conviction and rebrand her for the ceaseless inflow of global capitals and for the endless troupe of global tourists. “This is the spirit behind key legislations and reforms we have promoted in the 10th National Assembly. From the Tax Reform Bills, 2024 to National Minimum Wage Act, 2024, Investment and Securities Act, 2024 and National Ranches Commission Establishment Bill, 2024, among others, we are simply committed to building an environment where businesses can operate seamlessly; where investors will never think twice before they bring in their capitals; where our compatriots can freely breathe without undue burden and where the next generations will be proud of at all times.” He also disclosed that “We are pursuing each of these reforms purely in the love of our countrymen as Christ our Lord has commanded.This intention is more than evident in the case of Tax Reform Bills, 2024, a set of four initiatives consciously designed to reverse the country’s disturbing economic indicators. “We have taken due note of public concerns about these initiatives. We are, as well, looking deeply into the areas of public concern. Our duty, as democrats, is not just to listen to our constituents, but also give effect to policy initiatives that will positively impact their lives.” On the proposed Tax Reform Bill, the Senate Leader said when finally enacted, “it would utterly exempt all employees earning N1,000, 000 annually or N83,000 monthly; exempt start-ups, shared services and technologically driven services from taxation and recommend zero VAT on essential services and consumptions. Even though it reviews the derivation formula to 60%, this proposal is guided purely by the principles of equity, fairness and justice. “The new model will eventually guarantee a significant increase in VAT distributable to every state of the federation. As credible data have shown, for instance, the new model recommends 6.17% to Kano compared to 0.89% currently due to it. It recommends 1.21% for Zamfara compared to 0.05%. Currently, Lagos gets 80.26%, but the new model only recommends 15.28%, representing a 81% decrease. “Under the new model, also, Rivers’ share will decline from 7.74% to 4.6%, accounting for 41%. With these figures, the narrative around the new derivation model is utterly incorrect and unfounded. “Amid the debates about the Tax Reform Bills, as Christ our Lord has taught us and as the Parliament of the people, we shall never pursue any agenda outside our oath of allegiance or undertake policy initiatives adversarial to or conflicting the interest and welfare of all our constituents and indeed our Fatherland.”Henry Ford Macomb Hospital’s plan for more power runs into oppositionHochul asks Biden admin. for more border resources
Denosumab biosimilar is under clinical development by Samsung Bioepis and currently in Phase III for Post Menopausal Osteoporosis. According to GlobalData, Phase III drugs for Post Menopausal Osteoporosis have an 83% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Denosumab biosimilar overview Denosumab biosimilar (SB16) is under development for treatment of osteoporosis and prevention of skeletal related events with advanced malignancies and treatment of giant cell tumour of bone. The therapeutic candidate is a monoclonal antibody, which targets RANK ligand (RANKL). It is administered through subcutaneous route. Samsung Bioepis overview Samsung Bioepis, a subsidiary of Co Ltd, is a biopharmaceutical company. The company develops biosimilar products for immunology, oncology, ophthalmology, hematology, and endocrinology indications. It offers biological drugs for the treatment of Crohn’s disease, ulcerative colitis, psoriasis, cancer, and arthritis. The company is investigating SB12, an Eculizumab biosimilar targeting paroxysmal nocturnal hemoglobinuria; SB15, an Aflibercept biosimilar medicine against neovascular age-related macular degeneration; SB16, a denosumab biosimilar for the treatment of endocrinology disorders. Samsung Bioepis is also evaluating SB17, a Ustekinumab molecule against moderate to severe plaque psoriasis; and SB26 biosimilar to treat gastroenterology indications. Samsung Bioepis is headquartered in Incheon, Seoul, South Korea. For a complete picture of Denosumab biosimilar’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Fresolimumab by Sanofi for Non-Small Cell Lung Cancer: Likelihood of ApprovalA 70-year-old woman who almost took her life over a gambling addiction says cashless machines must be introduced in NSW. or signup to continue reading Marie, of Gamblers Anonymous in Newcastle, has been gamble-free for almost 24 years. "It's an emotional addiction that destroys the soul. You feel like there are no answers," Marie said. She said cashless gaming should involve limits on how much people can gamble. "A compulsive gambler cannot stop while they have access to money. If they get a win, they'll throw it back ," she said. The NSW government is considering the issue, after running a cashless gaming trial in 14 hotels and clubs from March to September this year. This included The Stag and Hunter Hotel in Mayfield and Fingal Bay Sports Club in Port Stephens. It will examine an "account-based gaming system" that allows "the to top up a player account up to a certain amount". The Independent Panel on Gaming Reform recommended this system, after the voluntary cashless trial found "uptake by patrons was very low". The government will also consider a "statewide exclusion register" with facial recognition technology to stop problem gambling. NSW Minister for Gaming and Racing David Harris said "we will be bringing in a first- and third-party exclusion system". "That's so people can exclude themselves, or family members can apply to exclude a loved one if it's causing harm," said Mr Harris, the Wyong MP. "To do that, every venue in the state needs to be able to recognise that person when they walk through the door." NSW budget papers show tax revenue from club and pub gaming machines is estimated to be $2.5 billion in 2024/25. "I still feel the government is addicted to gambling revenue," Marie said. "I believe cashless gaming is the only answer." She said poker machines "were my undoing". "I wish to god I hadn't got caught up with them. I hit rock bottom. It was a choice of committing suicide or getting some sort of help." She said her husband had "the wisdom to restrict my access to money, so the monkey was off the back". "I went to my first [Gamblers Anonymous] meeting and haven't touched a machine since. I was one of the fortunate ones. But I still have withdrawals. "Once this addiction gets hold, it's very hard to get out of it. Unless some restrictions are in place, things will get a lot worse before they get better." Mr Harris said the government had introduced responsible gaming officers and $500 limits on new poker machines bought after July 2023. "That will take a while to cycle through the system," he said. "We already got rid of gaming advertising around pubs. And we're stopping advertising outside gaming rooms." The government also banned gaming advertising that was "on or visible from" an ATM machine. "We're putting ATMs where they can't be seen from the gaming rooms," Mr Harris said. "In the 20 months we've been in government, we've done more in harm minimisation than the previous 30 to 50 years. "We've got to make that cultural change and slow it [gambling] down. Changing behaviour is difficult." Health and medicine, science, research, nutrition. Health and medicine, science, research, nutrition. Advertisement Sign up for our newsletter to stay up to date. We care about the protection of your data. Read our . Advertisement
Canada’s defence spending timeline ‘an eternity’ for U.S., senator warnsWASHINGTON (AP) — American Airlines briefly grounded flights nationwide Tuesday because of a technical problem just as the Christmas travel season kicked into overdrive and winter weather threatened more potential problems for those planning to fly or drive. Government regulators cleared American flights to get airborne about an hour after the Federal Aviation Administration ordered a national ground stop for the airline. The order, which prevented planes from taking off, was issued at the airline's request. The airline said in an email that the problem was caused by trouble with vendor technology that maintains its flight operating system. Dennis Tajer, a spokesperson for the Allied Pilots Association, a union representing American Airlines pilots, said the airline told pilots at 7 a.m. Eastern that there was an outage affecting the system known as FOS. It handles different types of airline operations, including dispatch, flight planning, passenger boarding, as well as an airplane's weight and balance data, he said. Some components of FOS have gone down in the past, but a systemwide outage is rare, Tajer said. Hours after the ground stop was lifted, Tajer said the union had not heard about any “chaos out there beyond just the normal heavy travel day.” He said officials were watching for any cascading effects, such as staffing problems. Flights were delayed across American's major hubs, with only 37% leaving on time, according to Cirium, an aviation analytics company. Out of the 3,901 domestic and international American Airlines flights scheduled for Tuesday, 19 were canceled. Cirium noted that the vast majority of flights were departing within two hours of their scheduled departure time. A similar percentage — 36% — were arriving at their destinations as scheduled. Meanwhile, the flight-tracking site FlightAware reported that 3,712 flights entering or leaving the U.S., or serving domestic destinations, were delayed Tuesday, with 55 flights canceled. It did not show any flights from American Airlines. Cirium said Dallas-Fort Worth, New York’s Kennedy Airport and Charlotte, North Carolina, saw the greatest number of delays. Washington, Chicago and Miami experienced considerably fewer delays. Amid the travel problems, significant rain and snow were expected in the Pacific Northwest at least into Christmas Day. Showers and thunderstorms were developing in the South. Freezing rain was reported in the Mid-Atlantic region near Baltimore and Washington, and snow fell in New York. Because the holiday travel period lasts weeks, airports and airlines typically have smaller peak days than they do during the rush around Thanksgiving, but the grind of one hectic day followed by another takes a toll on flight crews. And any hiccups — a winter storm or a computer outage — can snowball into massive disruptions. That is how Southwest Airlines stranded 2 million travelers in December 2022, and Delta Air Lines suffered a smaller but significant meltdown after a worldwide technology outage in July caused by a faulty software update from cybersecurity company CrowdStrike. Many flights during the holidays are sold out, which makes cancellations even more disruptive than during slower periods. That is especially true for smaller budget airlines that have fewer flights and fewer options for rebooking passengers. Only the largest airlines, including American, Delta and United, have “interline agreements” that let them put stranded customers on another carrier’s flights. This will be the first holiday season since a Transportation Department rule took effect that requires airlines to give customers an automatic cash refund for a canceled or significantly delayed flight. Most air travelers were already eligible for refunds, but they often had to request them. Passengers still can ask to get rebooked, which is often a better option than a refund during peak travel periods. That’s because finding a last-minute flight on another airline tends to be expensive. An American spokesperson said Tuesday was not a peak travel day for the airline — with about 2,000 fewer flights than the busiest days — so the airline had somewhat of a buffer to manage the delays. The groundings happened as millions of travelers were expected to fly over the next 10 days. The Transportation Security Administration expects to screen 40 million passengers through Jan. 2. Airlines expect to have their busiest days on Thursday, Friday and Sunday. Many flights during the holidays are sold out, which makes cancellations more disruptive than during slower periods. Even with just a brief outage, the cancellations have a cascading effect that can take days to clear up. About 90% of Americans traveling far from home over the holidays will be in cars, according to AAA. “Airline travel is just really high right now, but most people do drive to their destinations, and that is true for every holiday,” AAA spokesperson Aixa Diaz said. Gasoline prices are similar to last year. The nationwide average Thursday was $3.04 a gallon, down from $3.13 a year ago, according to AAA. Charging an electric vehicle averages just under 35 cents per per kilowatt hour, but varies by state. Transportation-data firm INRIX says travel times on the nation’s highways could be up to 30% longer than normal over the holidays, with Sunday expected to see the heaviest traffic. Boston, New York City, Seattle and Washington are the metropolitan areas primed for the greatest delays, according to the company. —— Associated Press writers David Koenig, Mae Anderson and Mike Pesoli contributed to this report.
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YOUR degree is just a piece of paper, your education is seen in your behaviour. That piece of advice is Joeli Varo’s food for thought for the younger generation. Hailing from Narayawo Village in the province of Namosi, Mr Varo’s journey from humble beginnings to becoming a respected academic and professional in land management is nothing short of inspirational. Growing up in Nakavu Village, Mr Varo was raised in a family of hardworking individuals. His mother was a dedicated teacher and his father was a truck driver with the then Public Works Department. They instilled in him the values of discipline and perseverance. The third of five siblings, he experienced the balance of both the challenges and privileges that come with being part of a large family. “We usually did farming back then,” Mr Varo said. “That’s where I developed my interest in land management.” Mr Varo attended Nakavu Village School from Class 1 to 8 then moved to Vashist Muni College in Navua where he completed his Form 3 and 4. “Back then, playing rugby was something that I wanted to see myself in 10 years. “When I was in Form 3, I wanted to go to a school where rugby was fully developed and the pathway for that had already been established. “So, I attended Suva Grammar School to complete Form 5 and 6.” However, as things would turn out, fate had other plans for the 34-year-old. While at SGS in Form 5 and 6, one of his teachers, a history instructor, took him under her wing. Her guidance helped Mr Varo realise that his future lay in education, not sports. He furthered his education at the University of the South Pacific. “The transition from secondary to tertiary was a bit challenging for me because my parents had retired. I had to be resilient. So, I had to go the extra mile in order to achieve access to education, like moving from Navua to Suva.” Part of the process involved going to the market to sell cassava for bus fares. “So, I had to really plan and manage my time. I had to ensure I kept up with the challenging environments that I’d gone through.” At USP, Mr Varo pursued a double major in land management and geography, with a minor in Geospatial Information Science (GIS). The hard work paid off when he completed his diploma in Land Management and Geography within two years, followed by a bachelor’s degree. After graduation, Mr Varo took on an internship at the Ministry of Lands. After three months , he received an email from his professor about a land scholarship opportunity to study in Trinidad. He applied and was accepted. This experience broadened his horizons and gave him a deeper understanding of land management on an international scale. Upon returning to Fiji, Mr Varo worked as a lands officer at the Ministry of Lands and Resources. He then moved on to the i-Taukei Land Trust Board as an estates officer. His career took another turn when he moved to Papua New Guinea’s University of Technology to pursue a doctorate in algematics. His thirst for knowledge led him back to Fiji, where he took up a position as a lecturer at the Fiji National University, teaching urban and regional planning as well as civil engineering. “I was at FNU for three years and until I moved to USP as a lecturer. It’s been a year now. “That’s where I am today. I want to be a professor, that is my long term goal, but I have another 10 years at least to work out my professorship.” As head of discipline for land management and development at USP, Mr Varo is focused on building the next generation of experts in the field. His advice to the younger generation? Respect is the key – it opens the doors of success. For Mr Varo, it’s not about what you acquire, but how you treat others that will ultimately open hearts and lead to success.
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