They say that there are two seasons in Canada: winter, and construction. With the snow finally here, and here to stay, London is wrapping up many construction projects, however some will continue despite the plunge into frigid temperatures. Ongoing construction of the Wellington Gateway will continue into the winter months – with upgrades coming to Colonel Talbot Road, Clark’s Bridge, and more. On the docket for completion in 2024 is the Oxford and Gideon Roundabout, the York Street Infrastructure Renewal, Stoney Creek Thames Valley Parkway Connection, and Mud Creek Phase 2B. If it feels like the Forest City has been a forest of cones, you’re not entirely wrong – many projects were completed in 2024, including the Adelaide Underpass, Victoria Bridge Replacement, the Downtown Loop Phase 3, the East London Link Phase 2, Wellington Gateway Phase 1, Fanshawe Park Road and Richmond Street Intersection Improvements, Mud Creek Phase 2A – Culvert installation on Oxford Street, and the neighbourhood road program. Shopping Trends The Shopping Trends team is independent of the journalists at CTV News. We may earn a commission when you use our links to shop. Read about us. Editor's Picks 20 Great Last-Minute Gifts From Amazon Canada That Won't Break The Bank 22 Tiny (And Wonderful) Gifts To Stuff Your Stockings With This Year 28 Crowd-Pleasing Gifts For The Pickiest People On Your List Home 14 Of The Best Home Security Devices You Can Find Online Right Now (And They've Got The Reviews To Prove It) 13 Of The Best Fidget Toys For Adults 16 Cozy Home Essentials That Cost Less Than $100 Gifts The Clock Is Ticking — Shop These 25 Last-Minute Amazon Prime Gifts Now If You Have An Amazon Prime Account, These 70+ Crowd-Pleasing Gifts Will Still Arrive Before Christmas If You Have An Amazon Prime Account, These 50 Brilliant Stocking Stuffers Will Still Arrive Before Christmas Beauty 20 Products Your Dry, Dehydrated Skin Will Thank You For Ordering 14 Hydrating Face Masks That’ll Save Your Skin This December 12 Budget-Friendly Products To Add To Your Winter Skincare Routine Deals The Silk & Snow End Of Year Sale Is Officially On — Here's What To Add To Your Cart The Best Early Boxing Day Deals On Amazon Canada For 2024 This Smart Security Camera System Will Help You Keep An Eye On Your Home (And It's On Sale For 50% Off Right Now) London Top Stories The Forest City has been a forest of cones, and with these projects on tap for 2025, get ready for round two New Canadians displaced after fire destroys east London townhome Feeling Festive? Check out this display of over 300 lit Christmas trees Sarnia Police Auxiliary Unit works to return stolen shopping carts to businesses London Ont. Liberal MPs say that Trudeau is taking time to reflect on his future Cold Weather Alert issued as temperatures could reach -18 ̊C or lower New rules clarify when travellers are compensated for flight disruptions Lights out in Listowel, OPP investigate motor vehicle collision with hydro box CTVNews.ca Top Stories Can the Governor General do what Pierre Poilievre is asking? This expert says no A historically difficult week for Prime Minister Justin Trudeau and his Liberal government ended with a renewed push from Conservative Leader Pierre Poilievre to topple this government – this time in the form a letter to the Governor General. Two U.S. Navy pilots shot down over Red Sea in apparent 'friendly fire' incident, U.S. military says Two U.S. Navy pilots were shot down Sunday over the Red Sea in an apparent 'friendly fire' incident, the U.S military said, marking the most serious incident to threaten troops in over a year of America targeting Yemen's Houthi rebels. Ottawa MP Mona Fortier appointed chief government whip Ottawa-Vanier MP Mona Fortier has been appointed as chief government whip, the latest addition in a major reshuffle of Prime Minister Justin Trudeau's cabinet. opinion | Tom Mulcair: Prime Minister Justin Trudeau's train wreck of a final act In his latest column for CTVNews.ca, former NDP leader and political analyst Tom Mulcair puts a spotlight on the 'spectacular failure' of Prime Minister Justin Trudeau's final act on the political stage. B.C. mayor gets calls from across Canada about 'crazy' plan to recruit doctors A British Columbia community's "out-of-the-box" plan to ease its family doctor shortage by hiring physicians as city employees is sparking interest from across Canada, says Colwood Mayor Doug Kobayashi. Bluesky finds with growth comes growing pains - and bots Bluesky has seen its user base soar since the U.S. presidential election, boosted by people seeking refuge from Elon Musk's X, which they view as increasingly leaning too far to the right given its owner's support of U.S. president-elect Donald Trump, or wanting an alternative to Meta's Threads and its algorithms. Big splash: Halifax mermaid waves goodbye after 16 years Halifax's Raina the Mermaid is closing her business after 16 years in the Maritimes. Arizona third-grader saves choking friend An Arizona third-grader is being recognized by his local fire department after saving a friend from choking. opinion | King Charles' Christmas: Who's in and who's out this year? Christmas 2024 is set to be a Christmas like no other for the Royal Family, says royal commentator Afua Hagan. King Charles III has initiated the most important and significant transformation of royal Christmas celebrations in decades. Kitchener 'I'm still thinking pinch me': lost puppy reunited with family after five years After almost five years of searching and never giving up hope, the Tuffin family received the best Christmas gift they could have hoped for: being reunited with their long-lost puppy. Impaired driver causes significant delays on Waterloo highway A 24-year-old man is facing charges after driving while drunk across two Waterloo Regional highways on Friday. Fire destroys home in Haldimand County A home in Haldimand County has been destroyed after a Saturday afternoon fire. Barrie One driver faces several charges following Highway 400 crash in Oro-Medonte Traffic came to a standstill Friday afternoon following a single-vehicle collision on Highway 400 in Oro-Medonte. High school teacher charged with sexual assault amid allegations involving a student A 51-year-old teacher from Georgina has been charged with sexual assault following allegations involving a student. Hospice Simcoe mourns loss of COPE service pup, after 7.5 years of service The Hospice Simcoe community is mourning the loss of their Canine Opportunity, People Empowerment (COPE) service dog, Daisy. Windsor Former workers of 'one-of-a-kind' entertainment hub reunite Former employees of the Elmwood Casino gathered outside their old stomping grounds Saturday, exactly 50 years after the prominent Windsor joint shut its doors. 'Heartwarming': Windsor-Essex families receive help filling underneath the tree Space under the Christmas tree became far more limited for several Windsor-Essex families who received a visit from volunteers at Project Christmas. 'It's got to stop, it's that simple': Windsor cab drivers warn of unregulated operators Drivers now compete with individuals using social media to advertise rides at cut-rate prices. One person offers $10 rides within the city, while another promotes daily trips from Windsor to Toronto for $45 per person. Northern Ontario Robinson Superior First Nations provided settlement offer from Canada over annuities owed Details haven’t been made public yet about the settlement offer presented on Friday by Canada to the 12 First Nations in the Robinson Superior Treaty Territory. Northern Ont. man illegally killed three moose, one deer A man from the northwestern Ontario community of Dinorwic has been found guilty of multiple hunting offences and fined $6,500, banned from hunting for five years and placed on probation for 18 months. opinion | Tom Mulcair: Prime Minister Justin Trudeau's train wreck of a final act In his latest column for CTVNews.ca, former NDP leader and political analyst Tom Mulcair puts a spotlight on the 'spectacular failure' of Prime Minister Justin Trudeau's final act on the political stage. Sault Ste. Marie Sault police seek public assistance in LCBO theft investigation Sault police are investigating a series of thefts at the LCBO on Second Line West earlier this month. Northern Credit Union makes donation to Lady Dunn Health Centre to show gratitude for exceptional care shown to staff Northern Credit Union has announced a $10,000 donation made in honour of the many individuals and organizations who stepped forward to support its team during and following last week’s tragic event. Northern Ont. hospital to close emergency department Sunday A physician shortage is again forcing the closure of the emergency department at the Thessalon Site of the North Shore Health Network. Ottawa OPP find wanted man by chance in eastern Ontario home, seize $50K worth of drugs A wanted eastern Ontario man was found with $50,000 worth of drugs and cash on him in a home in Bancroft, Ont. on Friday morning, according to the Ontario Provincial Police (OPP). What's open and closed in Ottawa over the holidays CTVNewsOttawa.ca takes a look at what's open and closed over the Christmas and New Year's holidays this year. What's happening in Ottawa over the Christmas holidays CTVNewsOttawa.ca looks at things to do in Ottawa over the holiday season. Toronto Cold in Toronto feels like -23 with the wind chill Sunday morning The cold weather hanging over Toronto isn’t letting up, and it currently feels like -23 with the wind chill. Toronto police investigating 2 separate east-end shootings, no injuries reported Toronto police are investigating two separate east-end shootings that occurred within 12 hours of each other. Three-vehicle crash leaves 4 people injured in Brampton Four people were injured in a three-car crash in Brampton early Sunday morning. Montreal Canadiens riding three-game win streak ahead of long stretch away from home The Montreal Canadiens are on a season-best win streak ahead of their longest stretch away from home. Patrik Laine scored on the power play, again, and the Montreal Canadiens defeated the Detroit Red Wings on consecutive nights with a 5-1 victory Saturday. Major factory fire in the Maskinonge, Que. A major fire devastated an industrial building in the municipality Maskinongé, Que on Saturday. West Island clinic set to close at the end of December Statcare Emergency Clinic in Pointe-Claire will shut its doors on Dec. 31. Atlantic Cape Breton police arrest second person in missing man investigation A second person has been arrested in the disappearance of Justin MacDonald in Cape Breton. Calling all bloodhounds: These P.E.I. blood donors have four legs and a tail Dogs are donating blood and saving the lives of canines at the University of Prince Edward Island's Atlantic Veterinary College in Charlottetown. Big splash: Halifax mermaid waves goodbye after 16 years Halifax's Raina the Mermaid is closing her business after 16 years in the Maritimes. Winnipeg Residential parking ban lifted in Winnipeg The City of Winnipeg has lifted its parking ban on residential streets, which means its winter route ban is back in effect. Muslim youth group distributes meals to Winnipeg's most vulnerable In the spirit of giving season, a Muslim youth group made its way through the city’s downtown distributing meals to those in need. Bail denied for Winnipeg woman accused of killing animals in online videos Warning: This story contains disturbing details. Discretion is advised. A Winnipeg woman accused of making videos of animals being tortured and killed that were sold on the dark web was denied bail. Calgary 'This shouldn't happen': Calgary family seeks changes after WestJet accessibility incident A Calgary woman wants WestJet to apologize to her daughter and to improve staff training on accessibility after an incident during their latest trip. Promise of high-level hockey comes at a cost for prep school players at Circle K Classic Calgary is set to host the Circle K Classic, welcoming some high-end talent and pricey prep schools for the annual U18 AAA hockey tournament. Flames get goals from 6 players in a 6-4 victory over the Blackhawks Jonathan Huberdeau, Connor Zary, Blake Coleman, and Matt Coronato each had a goal and an assist as the Calgary Flames beat the Chicago Blackhawks 6-4 on Saturday. Edmonton 'There’s no support': Domestic abuse survivor shares difficulties leaving her relationship An Edmonton woman who tried to flee an abusive relationship ended up back where she started in part due to a lack of shelter space. Icy conditions: Alberta RCMP warn of poor driving conditions on QEII between Leduc and Red Deer Alberta RCMP issued a warning to drivers Saturday morning about slick conditions on the QEII between Leduc and Red Deer. Heavy police presence in south Fort McMurray: RCMP RCMP warned Fort McMurray residents Saturday night about an unfolding police incident in Beacon Hill. Regina Gathering held in Regina to recognize Winter Solstice Regina's mâmawêyatitân centre held a day of gathering for the Winter Solstice on Saturday. Canada's first sustainable Tim Hortons location to open in Regina this weekend Canada’s first sustainable Tim Hortons opens in Regina this weekend. The restaurant, located in the city’s east end, features design and operating features that minimize environmental impact. Gravelbourg's transportation program celebrates addition of new vehicle and garage The town of Gravelbourg is celebrating the addition of a new vehicle and garage which will be used in their local transportation program. Saskatoon Sask. police investigating mischief incident after bomb report in school Prince Albert police are investigating a mischief incident after a bomb report in a school Friday afternoon. Prince Albert woman collects donations to make Christmas hampers for community A Prince Albert woman is spreading holiday cheer by organizing Christmas hampers for those in need. Sask. lawyers defend judge for staying fatal THC-impaired driving charge The Saskatchewan Trial Lawyers Association is defending a provincial court judge, who’s facing backlash for staying a charge in a high-profile case involving the death of a child. Vancouver Man wounded in Mission, B.C., shooting One man was injured in a shooting in the Lower Mainland city of Mission Saturday morning, Mounties confirmed. Winds exceeding 120 km/h reported in parts of B.C. coast Residents of parts of the British Columbia coast are again bracing for high winds, with gusts forecasted to reach 110 km/h in some areas. 2 dead after car crash in Burnaby Two people were killed in a car crash in Burnaby early Saturday morning, police confirmed. Vancouver Island B.C. mayor gets calls from across Canada about 'crazy' plan to recruit doctors A British Columbia community's "out-of-the-box" plan to ease its family doctor shortage by hiring physicians as city employees is sparking interest from across Canada, says Colwood Mayor Doug Kobayashi. B.C. woman with photographic memory strives to make unforgettable Christmas displays Although Alisha Pauling is looking through old pictures, she doesn’t need them to remember her Christmases past. She has a photographic memory. Internet stranger's kind gesture restores Canucks fan's faith in humanity A Nanaimo, B.C., couple is in awe at the kindness of an internet stranger who helped them track down a coveted Christmas gift. Stay Connected
RVision Homes: Revolutionizing Custom Home Building with Revolutionary Design Approach 11-25-2024 10:44 PM CET | Industry, Real Estate & Construction Press release from: ABNewswire Magnolia, TX - RVision Homes [ https://rvisionhomes.com ], one of Texas' top high-end luxury custom builders in Texas, is proud to announce its new innovative design approach that will set a new standard for custom home construction in the Houston Metro Area. Creating a new dimension with a focus on sustainability, smart technology, and personalized design, RVision Homes is putting a new lens on how people think about their dream homes. It now offers its reputation for excellence in Magnolia, Waller, Montgomery, and surrounding areas by offering an enhanced, fully integrated approach to custom home building. That means introducing state-of-the-art virtual design consultations, eco-friendly construction practices, and advanced smart home features to make sure each project is environmentally responsible and also future-ready. A Personalized Approach to Home Building "A home is so much more than just a house," Gretchen Rogers, Co-Owner of RVision Homes added, "it is an expression of who you are and the lifestyle you wish to have. It's for this reason that we have concentrated on building a process that is as unique as each of our clients.". From the first virtual consultation to the final walkthrough, every detail is envisioned to align with your preference while integrating the latest in sustainable technology and modern amenities. RVision Homes always boasts about personalized service. However, with the new changes, the company is now proposing a completely immersive, remote design experience. This is where clients will be able to sit down with architects, interior designers, and builders, all from the comfort of their own homes because of interactive online consultations. This especially benefits out-of-state clients or those whose availability is limited to visiting construction sites from time to time. Building for the Future: Smart Homes and Sustainability In addition to its personalized services, RVision Homes is also pushing forward in making homes not only luxurious but also truly environmentally friendly. For every project it embarks on, the company has promised to enact such green building practices as energy-efficient appliances, sustainable materials, and even solar panel options. As part of their dedication to building homes that embrace modern technology, RVision Homes is also incorporating smart home systems as a standard feature. Clients can expect to have complete control over their home's lighting, temperature, security, and more-all from their smartphone or voice-controlled devices. Expanding Reach: Building Across the Houston Metro Area Building on this established success, RVision Homes [ https://rvisionhomes.com]is branching out to more areas around Houston Metro. The company has its custom home building services in Willis and Plantersville and more, providing the home owners of Texas with a taste of their signature style and great craftsmanship. We are excited to expand our services to new areas and bring our unmatched expertise in luxury custom home building to even more families," stated Ryan Rogers, Co-Owner of RVision Homes. "Whether you're building on your own land or looking for help finding the perfect site, our team is here to assist you every step of the way." For more information about RVision Homes, or to begin planning your dream home, please visit https://rvisionhomes.com About RVision Homes RVision Homes is a luxury custom home builder known for delivering exceptional homes throughout the greater Houston area. With customized design and environmentally friendly construction, RVision Homes has been an industry leader for years in Texas. From custom floor plans to the installment of smart home systems, RVision Homes is here to make the process as frictionless as possible. Media Contact Company Name: RVision Homes Contact Person: Gretchen Rogers and Ryan Rogers Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=rvision-homes-revolutionizing-custom-home-building-with-revolutionary-design-approach ] Country: United States Website: https://rvisionhomes.com This release was published on openPR.Big Oil Still Betting On Plastics Despite Sector Going Bust
New Marvell AI accelerator (XPU) architecture enables up to 25% more compute, 33% greater memory while improving power efficiency. Marvell collaborating with Micron, Samsung and SK hynix on custom high-bandwidth memory (HBM) solutions to deliver custom XPUs. Architecture comprises advanced die-to-die interfaces, HBM base dies, controller logic and advanced packaging for new XPU designs. SANTA CLARA, Calif. , Dec. 10, 2024 /PRNewswire/ -- Marvell Technology, Inc. (NASDAQ: MRVL), a leader in data infrastructure semiconductor solutions, today announced that it has pioneered a new custom HBM compute architecture that enables XPUs to achieve greater compute and memory density. The new technology is available to all of its custom silicon customers to improve the performance, efficiency and TCO of their custom XPUs. Marvell is collaborating with its cloud customers and leading HBM manufacturers, Micron, Samsung Electronics, and SK hynix to define and develop custom HBM solutions for next-generation XPUs. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.
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ENGLEWOOD, Colo. (AP) — John Elway says any remorse over bypassing Josh Allen in the 2018 NFL draft is quickly dissipating with rookie Bo Nix's rapid rise, suggesting the Denver Broncos have finally found their next franchise quarterback. Elway said Nix, the sixth passer selected in April's draft, is an ideal fit in Denver with coach Sean Payton navigating his transition to the pros and Vance Joseph's defense serving as a pressure release valve for the former Oregon QB. “We’ve seen the progression of Bo in continuing to get better and better each week and Sean giving him more each week and trusting him more and more to where last week we saw his best game of the year,” Elway said in a nod to Nix's first game with 300 yards and four touchdown throws in a rout of Atlanta. For that performance, Nix earned his second straight NFL Rookie of the Week honor along with the AFC Offensive Player of the Week award. “I think the sky’s the limit," Elway said, “and that’s just going to continue to get better and better.” In a wide-ranging interview with The Associated Press, Elway also touted former coach Mike Shanahan's Hall of Fame credentials, spoke about the future of University of Colorado star and Heisman favorite Travis Hunter and discussed his ongoing bout with a chronic hand condition. Elway spent the last half of his decade as the Broncos’ GM in a futile search for a worthy successor to Peyton Manning, a pursuit that continued as he transitioned into a two-year consultant role that ended after the 2022 season. “You have all these young quarterbacks and you look at the ones that make it and the ones that don’t and it’s so important to have the right system and a coach that really knows how to tutelage quarterbacks, and Sean’s really good at that,” Elway said. “I think the combination of Bo’s maturity, having started 61 games in college, his athletic ability and his knowledge of the game has been such a tremendous help for him,'" Elway added. “But also Vance Joseph’s done a heck of a job on the defensive side to where all that pressure’s not being put on Bo and the offense to score all the time.” Payton and his staff have methodically expanded Nix’s repertoire and incorporated his speed into their blueprints. Elway lauded them for “what they’re doing offensively and how they’re breaking Bo into the NFL because it’s a huge jump and I think patience is something that goes a long way in the NFL when it comes down to quarterbacks.” Elway said he hopes to sit down with Nix at some point when things slow down for the rookie. Nix, whose six wins are one more than Elway had as a rookie, said he looks forward to meeting the man who won two Super Bowls during his Hall of Fame playing career and another from the front office. “He’s a legend not only here for this organization, but for the entire NFL," Nix said, adding, "most guys, they would love to have a chat with John Elway, just pick his brain. It’s just awesome that I’m even in that situation.” Orange Crush linebacker Randy Gradishar joined Elway in the Pro Football Hall of Fame this year, something Elway called “way, way overdue.” Elway suggested it's also long past time for the Hall to honor Shanahan, who won back-to-back Super Bowls in Denver with Elway at QB and whose footprint you see every weekend in the NFL because of his expansive coaching tree. Elway called University of Colorado stars Travis Hunter and Shedeur Sanders “both great athletes." He said he really hopes Sanders gets drafted by a team that will bring him along like the Broncos have done with Nix and he sees Hunter being able to play both ways in the pros but not full time. Elway said he thinks Hunter will be primarily a corner in the NFL but with significant contributions on offense: “He's great at both. He's got great instincts, and that's what you need at corner." It's been five years since Elway announced he was dealing with Dupuytren’s contracture, a chronic condition that typically appears after age 40 and causes one or more fingers to permanently bend toward the palm. Elway's ring fingers on both hands were originally affected and he said now the middle finger on his right hand is starting to pull forward. So, he’ll get another injection of a drug called Xiaflex, which is the only FDA-approved non-surgical treatment, one that he's endorsing in an awareness campaign for the chronic condition that affects 17 million Americans. The condition can make it difficult to do everyday tasks such as shaking hands or picking up a coffee mug. Elway said what bothered him most was “I couldn't pick up a football and I could not imagine not being able to put my hand around a football." AP NFL: https://apnews.com/hub/nfl
Gophers coach P.J. Fleck explains trick play call on game-defining drive in Penn State lossInterim analysis shows that tecovirimat did not improve time to lesion resolution compared to placebo in adults with mild to moderate clade II mpox Study stopped enrolling patients in all study arms Results affirm tecovirimat's strong safety profile Efficacy in patients with more severe disease not assessed in study NEW YORK, Dec. 10, 2024 (GLOBE NEWSWIRE) -- The National Institutes of Health's (NIH) National Institute of Allergy and Infectious Diseases (NIAID) today announced results from an interim analysis of the Study of Tecovirimat for Human Mpox Virus (STOMP) clinical trial (NCT05534984). NIAID reported that SIGA's tecovirimat, a highly targeted antiviral treatment, did not demonstrate efficacy in time to skin and mucosal lesion resolution compared to placebo in patients with mild to moderate clade II mpox. Based on this and additional analyses, the study Data Safety and Monitoring Board (DSMB) recommended to stop enrolling patients in the randomized arms of the study. NIAID accepted this recommendation and subsequently decided to take a similar action in the open label arm of this study, which included severe and at-risk of developing severe disease patients. Data analysis is not yet complete for primary endpoint subgroups and detailed secondary and exploratory endpoints. "Antivirals are most effective when administered early in the course of an infection and tend to demonstrate the greatest benefit in patients with more severe disease. The STOMP results are not unexpected as the study design was similar to the PALM007 study except it was in patients with mild to moderate clade II mpox compared to patients with clade I mpox. It is important to note that approximately 75% of mpox patients in the randomized arms of the STOMP trial received tecovirimat more than five days after symptom onset, and higher risk patients were included in an open-label arm," stated Diem Nguyen, Chief Executive Officer. Tecovirimat, also known as TPOXX, was developed in partnership with the U.S. Government and approved by the U.S. Food and Drug Administration to treat smallpox—a virus closely related to, but far more serious than, mpox. TPOXX was approved in 2018 based on data from 12 clinical trials of oral TPOXX in 700 healthy human volunteers, which showed no drug-related serious adverse events. Four pivotal trials in non-human primates (NHPs) and two pivotal trials in rabbits demonstrated that TPOXX significantly reduced both mortality and viral load in NHP infected with mpox virus and in rabbits infected with rabbitpox virus. The results of the animal efficacy studies were published in the July 5, 2018 issue of the New England Journal of Medicine . "Tecovirimat's mechanism of action is driven by halting viral transmission. Once virus is present in the system, the body's natural immune system plays a central role in clearing it, typically within two to four weeks in immune competent patients. Research results thus far indicate that early treatment with tecovirimat including post-exposure prophylaxis and treatment in severe cases may offer the greatest potential for patient benefit," stated Dennis Hruby, Chief Scientific Officer. Additionally, in this study, tecovirimat exhibited a safety profile comparable to placebo. These safety results are consistent with prior studies and further support the strong safety profile that has been observed with tecovirimat over the past 15 years. Dr. Nguyen continued, "We thank our partners, the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institutes of Health (NIH), the patients who participated in this trial, and the investigators who supported this trial. Their unwavering dedication to public health has been instrumental in advancing our understanding of mpox and tecovirimat." Three randomized clinical trials, UNITY (Switzerland, Brazil, Argentina), Platinum-CAN (Canada), and EPOXI (EU), are enrolling mpox patients. Given the STOMP and PALM007 results and the design similarities across these mpox trials, the Company believes these ongoing trials are likely to yield similar results. About the STOMP Clinical Trial in Mpox The STOMP study is a randomized, placebo-controlled, double-blind study to evaluate the safety and efficacy of tecovirimat for the treatment of people with laboratory-confirmed or presumptive mpox disease. Beginning in September 2022, the study enrolled participants with mpox from Argentina, Brazil, Japan, Mexico, Peru, Thailand, and the United States, including Puerto Rico, who had symptoms for less than 14 days. Participants were randomly (2:1) assigned to receive tecovirimat or a placebo for 14 days. The number of capsules and frequency of dosage were based on patient weight. Participants with severe disease, certain skin conditions, or significantly suppressed immune systems received open-label tecovirimat rather than being randomized. The study monitored participants' safety across randomized and open label arms. In the randomized arms, STOMP examined the time to full mpox lesion resolution, viral clearance, and study participants' reports of pain. Participants were followed for 28 days with a study site visit at day 29 and then again at day 57 for possible recrudescence of infection. About SIGA SIGA Technologies (SIGA) SIGA is a commercial-stage pharmaceutical company and leader in global health focused on the development of innovative medicines to treat and prevent infectious diseases. With a primary focus on orthopoxviruses, we are dedicated to protecting humanity against the world's most severe infectious diseases, including those that occur naturally, accidentally, or intentionally. Through partnerships with governments and public health agencies, we work to build a healthier and safer world by providing essential countermeasures against these global health threats. Our flagship product, TPOXX® (tecovirimat), is an antiviral medicine approved in the U.S. and Canada for the treatment of smallpox and authorized in Europe and the UK for the treatment of smallpox, mpox (monkeypox), cowpox, and vaccinia complications. For more information about SIGA, visit www.siga.com . Forward-Looking Statements This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including statements relating to the efficacy of tecovirimat to treat mpox in certain patient populations and the results of ongoing mpox clinical studies. Forward-looking statements include statements regarding our future financial position, business strategy, budgets, projected costs, plans and objectives of management for future operations. The words "may," "continue," "estimate," "intend," "plan," "will," "believe," "project," "expect," "seek," "anticipate," "could," "should," "target," "goal," "potential" and similar expressions may identify forward-looking statements, but the absence of these words does not necessarily mean that a statement is not forward-looking. Such forward-looking statements are subject to various known and unknown risks and uncertainties, and SIGA cautions you that any forward-looking information provided by or on behalf of SIGA is not a guarantee of future performance. SIGA's actual results could differ materially from those anticipated by such forward-looking statements due to a number of factors, some of which are beyond SIGA's control, including, but not limited to, (i) the risk that BARDA elects, in its sole discretion as permitted under the 75A50118C00019 BARDA Contract (the "BARDA Contract"), not to exercise the remaining unexercised option under the BARDA Contract, (ii) the risk that SIGA may not complete performance under the BARDA Contract on schedule or in accordance with contractual terms, (iii) the risk that the BARDA Contract or U.S. Department of Defense contracts are modified or canceled at the request or requirement of, or SIGA is not able to enter into new contracts to supply TPOXX to, the U.S. Government, (iv) the risk that the nascent international biodefense market does not develop to a degree that allows SIGA to continue to successfully market TPOXX internationally, (v) the risk that potential products, including potential alternative uses or formulations of TPOXX that appear promising to SIGA or its collaborators, cannot be shown to be efficacious or safe in subsequent pre-clinical or clinical trials, (vi) the risk that target timing for deliveries of product to customers, and the recognition of related revenues, are delayed or adversely impacted by the actions, or inaction, of contract manufacturing organizations, or other vendors, within the supply chain, or due to coordination activities between the customer and supply chain vendors, (vii) the risk that SIGA or its collaborators will not obtain appropriate or necessary governmental approvals to market these or other potential products or uses, (viii) the risk that SIGA may not be able to secure or enforce sufficient legal rights in its products, including intellectual property protection, (ix) the risk that any challenge to SIGA's patent and other property rights, if adversely determined, could affect SIGA's business and, even if determined favorably, could be costly, (x) the risk that regulatory requirements applicable to SIGA's products may result in the need for further or additional testing or documentation that will delay or prevent SIGA from seeking or obtaining needed approvals to market these products, (xi) the risk that the volatile and competitive nature of the biotechnology industry may hamper SIGA's efforts to develop or market its products, (xii) the risk that changes in domestic or foreign economic and market conditions may affect SIGA's ability to advance its research or may affect its products adversely, (xiii) the effect of federal, state, and foreign regulation, including drug regulation and international trade regulation, on SIGA's businesses, (xiv) the risk of disruptions to SIGA's supply chain for the manufacture of TPOXX®, causing delays in SIGA's research and development activities, causing delays or the re-allocation of funding in connection with SIGA's government contracts, or diverting the attention of government staff overseeing SIGA's government contracts, (xv) risks associated with actions or uncertainties surrounding the debt ceiling, (xvi) the risk that the U.S. or foreign governments' responses (including inaction) to national or global economic conditions or infectious diseases, are ineffective and may adversely affect SIGA's business, and (xvii) risks associated with responding to an mpox outbreak, as well as the risks and uncertainties included in Item 1A "Risk Factors" of our Annual Report on Form 10-K for the year ended December 31, 2023 and SIGA's subsequent filings with the Securities and Exchange Commission. SIGA urges investors and security holders to read those documents free of charge at the SEC's website at http://www.sec.gov . All such forward-looking statements are current only as of the date on which such statements were made. SIGA does not undertake any obligation to update publicly any forward-looking statement to reflect events or circumstances after the date on which any such statement is made or to reflect the occurrence of unanticipated events. Contacts: Suzanne Harnett sharnett@siga.com and Investors Media Jennifer Drew-Bear, Edison Group Holly Stevens, Berry & Company Jdrew-bear@edisongroup.com hstevens@berrypr.com © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
Goalie Thatcher Demko poised to make first Canuck start of the seasonConnections: Sports Edition is a new version of the popular New York Times word game that seeks to test the knowledge of sports fans. Like the original Connections , the game is all about finding the "common threads between words." And just like Wordle , Connections resets after midnight and each new set of words gets trickier and trickier—so we've served up some hints and tips to get you over the hurdle. If you just want to be told today's puzzle, you can jump to the end of this article for the latest Connections solution. But if you'd rather solve it yourself, keep reading for some clues, tips, and strategies to assist you. What is Connections Sports Edition? The NYT 's latest daily word game has launched in association with The Athletic , the New York Times property that provides the publication's sports coverage. Connections can be played on both web browsers and mobile devices and require players to group four words that share something in common. Each puzzle features 16 words and each grouping of words is split into four categories. These sets could comprise of anything from book titles, software, country names, etc. Even though multiple words will seem like they fit together, there's only one correct answer. If a player gets all four words in a set correct, those words are removed from the board. Guess wrong and it counts as a mistake—players get up to four mistakes until the game ends. Players can also rearrange and shuffle the board to make spotting connections easier. Additionally, each group is color-coded with yellow being the easiest, followed by green, blue, and purple. Like Wordle, you can share the results with your friends on social media. Here's a hint for today's Connections Sports Edition categories Want a hint about the categories without being told the categories? Then give these a try: Here are today's Connections Sports Edition categories Need a little extra help? Today's connections fall into the following categories: Looking for Wordle today? Here's the answer to today's Wordle. Ready for the answers? This is your last chance to turn back and solve today's puzzle before we reveal the solutions. Drumroll, please! The solution to today's Connections Sports Edition #98 is... What is the answer to Connections Sports Edition today Don't feel down if you didn't manage to guess it this time. There will be new Connections for you to stretch your brain with tomorrow, and we'll be back again to guide you with more helpful hints. Are you also playing NYT Strands? See hints and answers for today's Strands . If you're looking for more puzzles, Mashable's got games now! Check out our games hub for Mahjong, Sudoku, free crossword, and more.
Macron, Trump, Zelensky discuss crazy world in Paris
GIRONA, Spain (AP) — Real Madrid coach Carlo Ancelotti said Jude Bellingham was not injured after his midfielder asked to substituted for what appeared to be a left thigh issue during a 3-0 win at Girona in La Liga on Saturday. “Bellingham is fine,” Ancelotti said. “He was just a bit tired and preferred not to risk anything in the final minutes.” That means Bellingham should be available when Madrid visits Atalanta on Tuesday in the Champions League, where it has lost three of five matches. Bellingham led Madrid's win after extending his scoring run to five consecutive league games for Madrid. He then set up Arda Guler to double the lead. The England midfielder asked to leave the match after he went down following contact with a Girona player with half an hour left. He rubbed his inner left thigh while he remained on the turf before walking off when replaced by Dani Ceballos with Madrid winning 2-0. Kylian Mbappé added a third goal after Bellingham was on the bench. AP soccer: https://apnews.com/hub/soccer